Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100043
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Development of an ultra-high speed spinning disk confocal micro-particle image velocimetry (PIV) platform for the investigation of cardiovascular disease . This facility will establish a microscope system specifically designed to investigate the function of blood cells in the context of cardiovascular diseases such as heart attack and stroke.
New quantum and robust control theory with applications to quantum optics. The application of quantum mechanics to the creation of quantum technology promises to be one of the most exciting technological developments of this century. Possible applications of quantum technologies include vastly improved sensors to search for minerals or gravity waves, secure quantum cryptography, and quantum computing. Quantum feedback control is a key tool in quantum technology. This project will lay the fou ....New quantum and robust control theory with applications to quantum optics. The application of quantum mechanics to the creation of quantum technology promises to be one of the most exciting technological developments of this century. Possible applications of quantum technologies include vastly improved sensors to search for minerals or gravity waves, secure quantum cryptography, and quantum computing. Quantum feedback control is a key tool in quantum technology. This project will lay the foundations of systematic theories of robust, coherent and nonlinear quantum feedback control and lead to advances in the control of highly resonant systems which underlie experimental quantum and nano technology. This will enable Australia to reap great benefits as this new technological area emerges.Read moreRead less
Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nan ....Multiblock copolymer synthesis for nano-engineered materials. This project aims to develop methodology for environmentally friendly and industrially applicable synthesis of new types of advanced polymeric materials comprising multiblock copolymers. Polymeric materials play an important role in society with applications from bulk plastics to advanced technological applications. This would enable the creation of advanced materials with specific engineering targets and applications ranging from nanomedicine to materials science.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100177
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Advanced electron paramagnetic resonance (EPR) facilities for chemical, biological and materials sciences. New instrumentation to advance national research in hydrogen fuel generation from renewable sources, new generation photo-voltaic technologies, novel polymer and other chemical materials and advanced computing systems will be provided by this project. A new high sensitivity electron paramagnetic resonance facility, located at the Australian National University, will serve researchers in the ....Advanced electron paramagnetic resonance (EPR) facilities for chemical, biological and materials sciences. New instrumentation to advance national research in hydrogen fuel generation from renewable sources, new generation photo-voltaic technologies, novel polymer and other chemical materials and advanced computing systems will be provided by this project. A new high sensitivity electron paramagnetic resonance facility, located at the Australian National University, will serve researchers in the ACT region devoted to the broad range of activities summarised above. A particular focus involves novel, biologically inspired energy systems and high efficiency solar cell technology.Read moreRead less
Generalised Energy Based Robust and Nonlinear Control Systems. This project aims to develop new energy-based theories of robust stability analysis and controller design for both linear and nonlinear systems, building on passivity and negative imaginary system theories and their physical interpretations along with stochastic optimal control theory. These control theories would allow for a wide range of plant dynamics in the design of high-performance robust control systems, enabling advances in e ....Generalised Energy Based Robust and Nonlinear Control Systems. This project aims to develop new energy-based theories of robust stability analysis and controller design for both linear and nonlinear systems, building on passivity and negative imaginary system theories and their physical interpretations along with stochastic optimal control theory. These control theories would allow for a wide range of plant dynamics in the design of high-performance robust control systems, enabling advances in emerging technologies including nanopositioning, micro-electromechanical systems and opto-mechatronics. The project plans to combine these theoretical advances with numerical methods involving advanced optimisation tools and the experimental implementation of nanopositioning control systems in atomic force microscopy.Read moreRead less
Safety in the Heavy Vehicle Industry: A Collaborative Response. The management and regulation of heavy vehicles, particularly in relation to safety, is recognised as an urgent issue at all levels of government across Australia. In the absence of research that identifies the key determinants of heavy vehicle crashes, countermeasures will continue to be based on anecdote. The proposed study will determine the role key risk factors, namely scheduling and sleep-related factors, play in heavy vehicl ....Safety in the Heavy Vehicle Industry: A Collaborative Response. The management and regulation of heavy vehicles, particularly in relation to safety, is recognised as an urgent issue at all levels of government across Australia. In the absence of research that identifies the key determinants of heavy vehicle crashes, countermeasures will continue to be based on anecdote. The proposed study will determine the role key risk factors, namely scheduling and sleep-related factors, play in heavy vehicle crashes and will identify cost-effective strategies to reduce the growing economic burden associated with these crashes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102873
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Securing networked control and estimation systems and safeguarding critical infrastructure. The purpose of this project is to reduce the likelihood of success, and the severity of impact, of a cyber-attack against networked control and estimation systems operating within critical infrastructure. The outcome will be a suite of algorithms, tools and design considerations for networked, industrial, control systems that satisfy this purpose.