Personalised Exercise As Medicine. Optimising The Prescription To Maximise The Benefit
Funder
National Health and Medical Research Council
Funding Amount
$772,490.00
Summary
Humans have never been less physically active than in contemporary Western society. These studies will provide an evidence-basis to address the inactivity epidemic by laying the foundation for personalised and effective exercise prescriptions, to which people are more likely to adhere.
Biomarkers For The Diagnosis And Prognostic Analysis Of Male Infertility
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
Male infertility is a common condition, affecting 1 in 15 men. Although a standard semen analysis is often performed to test whether a man is infertile, it is far from definitive. We have developed a new approach, by looking at proteins that are commonly missing from infertile sperm cells. From this analysis, we can definitively diagnose male infertility and are beginning to understand why men are becoming infertile.
Identifying Novel Targets To Treat And Prevent Diabetic Complications
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
Diabetes is the leading cause for kidney failure requiring dialysis or transplantation. Diabetic patients also have a higher risk to suffer from heart attacks, stroke and amputations in particular once kidney damage occurs. Current strategies fail to completely protect patients from complications. My research will uncover knowledge gaps in our understanding of diabetes complications, identify new targets ultimately leading to urgently needed more effective treatments and prevention strategies to ....Diabetes is the leading cause for kidney failure requiring dialysis or transplantation. Diabetic patients also have a higher risk to suffer from heart attacks, stroke and amputations in particular once kidney damage occurs. Current strategies fail to completely protect patients from complications. My research will uncover knowledge gaps in our understanding of diabetes complications, identify new targets ultimately leading to urgently needed more effective treatments and prevention strategies to reduce the burden of disease in diabetes.Read moreRead less
Reducing Disparities In Heart Disease-Related Morbidity And Mortality: Optimising Prevention And Management
Funder
National Health and Medical Research Council
Funding Amount
$826,854.00
Summary
Heart disease contributes to a large but potentially preventable burden of death and disability. This burden is uneven with particularly vulnerable/at risk groups - including those living in regional areas and developing countries, Indigenous Australians and older patients with chronic heart disease. Prof. Simon Stewart will lead national/international collaborations to undertake innovative, multidisciplinary, prevention and disease management programs to reduce the impact and burden of heart di ....Heart disease contributes to a large but potentially preventable burden of death and disability. This burden is uneven with particularly vulnerable/at risk groups - including those living in regional areas and developing countries, Indigenous Australians and older patients with chronic heart disease. Prof. Simon Stewart will lead national/international collaborations to undertake innovative, multidisciplinary, prevention and disease management programs to reduce the impact and burden of heart disease in these vulnerable groups.Read moreRead less
The Role Of Oxidative Processes In Atherosclerosis And Related Diseases
Funder
National Health and Medical Research Council
Funding Amount
$966,135.00
Summary
Atherosclerosis and related cardiovascular disease (CVD) remains the single major cause of death and burden to health in Australia. Currently available drugs reduce the known risk factors for CVD (e.g., blood pressure, cholesterol). However, there is a need to develop novel drugs that protect in ways other than decreasing risk factors. This Fellowship will enable us to extend our basic studies on atherogenesis, with a focus on the role of oxidative processes, and to translate our key findings in ....Atherosclerosis and related cardiovascular disease (CVD) remains the single major cause of death and burden to health in Australia. Currently available drugs reduce the known risk factors for CVD (e.g., blood pressure, cholesterol). However, there is a need to develop novel drugs that protect in ways other than decreasing risk factors. This Fellowship will enable us to extend our basic studies on atherogenesis, with a focus on the role of oxidative processes, and to translate our key findings into novel therapeutics and diagnostics.Read moreRead less
Enzymes that generate or degrade peptides serve important roles - alterations in their activity can impact on a diverse range of physiological processes in healthy and diseased states. Angiotensin is a peptide that plays a critical role in regulating blood pressure and fluid balance - drugs that block the activity of its processing enzymes forms an important class of medication used to treat hypertension and heart disease. My research interest is in discovering novel roles for these enzymes.
Craig Anderson is a clinician-scientist, with specialist training in neurology and geriatrics, and an internationally-recognised epidemiologist and clinical trialist researcher. His work is dedicated to generating the highest quality evidence to improve the prevention and treatment of stroke and other neurological diseases related to ageing.
The identification, prevention and management of chronic disease risk factors and understanding impact on clinical outcomes is fundamental to improving health and well-being. The program of work encapsulated in this application utilises a number of research methods to advance our understanding and provide new directions for cardiovascular disease prevention and management.
Understanding Lymphatic And Vascular Biology For Application To Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
This research is designed to provide further understanding of the role that the blood and lymphatic vessels plays in human disease. The proposal will use advanced molecular and cell biological approaches to define new diagnostic and therapeutic targets for human disease.
Affordable And Scaleable New Strategies For Cardiovascular Disease Control
Funder
National Health and Medical Research Council
Funding Amount
$609,384.00
Summary
This Fellowship will support Professor Anthony Rodgers to continue a track record of excellence in health research, public-private partnerships and innovation. He has led landmark cardiovascular trials and was Principal Author of the WHO World Health Report. He plans a program of research on new combination cardiovascular medicines ('polypills'). Polypill trials that Professor Rodgers initiated have recently shown improved clinical outcomes, patient acceptability, quality of life and cost saving ....This Fellowship will support Professor Anthony Rodgers to continue a track record of excellence in health research, public-private partnerships and innovation. He has led landmark cardiovascular trials and was Principal Author of the WHO World Health Report. He plans a program of research on new combination cardiovascular medicines ('polypills'). Polypill trials that Professor Rodgers initiated have recently shown improved clinical outcomes, patient acceptability, quality of life and cost savings.Read moreRead less