Cardiovascular and Respiratory Activity During Sleep Onset. Going to sleep requires that behavioural and physiological activities be modified. This is achieved by the integrated activity of sleep mechanisms and the circadian system. In this project we will investigate the nature of the regulatory control exerted by sleep mechanisms over respiration and cardiovascular activity at sleep onset, how sleep control interacts with circadian influence, and the nature of cardio-respiratory activity when ....Cardiovascular and Respiratory Activity During Sleep Onset. Going to sleep requires that behavioural and physiological activities be modified. This is achieved by the integrated activity of sleep mechanisms and the circadian system. In this project we will investigate the nature of the regulatory control exerted by sleep mechanisms over respiration and cardiovascular activity at sleep onset, how sleep control interacts with circadian influence, and the nature of cardio-respiratory activity when sleep control is removed at an arousal from sleep. It is anticipated that a better understanding of the regulatory control exerted by sleep over other systems will improve our understanding of sleep disorders.Read moreRead less
Respiratory and Cardiovascular Activation at Arousal from Sleep. An arousal from sleep, no matter how brief, is assciated with increased activity in the respiratory and cardiac systems. Under normal circumstances the response is considered adaptive. However, in disorders of sleep in which individuals arouse frequently and their sleep is fragmented, such as in Obstructive Sleep Apnea, the phenomenon has been linked to hypertension. While the clinical consequences of sleep fragmentation are now ap ....Respiratory and Cardiovascular Activation at Arousal from Sleep. An arousal from sleep, no matter how brief, is assciated with increased activity in the respiratory and cardiac systems. Under normal circumstances the response is considered adaptive. However, in disorders of sleep in which individuals arouse frequently and their sleep is fragmented, such as in Obstructive Sleep Apnea, the phenomenon has been linked to hypertension. While the clinical consequences of sleep fragmentation are now apparent, the mechanism that causes the increase in physiological activity at each arousal, is not known. The aim of this project will provide insight into the mechanism that produces the activation response and provide a basis for minimising the cardiac consequences of sleep disorders.Read moreRead less
Sleep and circadian influences on mood and Autonomic Nervous System control of the heart. Most biological and behavioural processes have a 24-hour oscillation in activity. A critical question is whether this oscillation is a consequence of the sleep-wake cycle or the circadian system (our internal biological clock). This project will investigate circadian influence over two biological systems that have important influences over behaviour, the Autonomic Nervous System (ANS) and the Behavioural Fa ....Sleep and circadian influences on mood and Autonomic Nervous System control of the heart. Most biological and behavioural processes have a 24-hour oscillation in activity. A critical question is whether this oscillation is a consequence of the sleep-wake cycle or the circadian system (our internal biological clock). This project will investigate circadian influence over two biological systems that have important influences over behaviour, the Autonomic Nervous System (ANS) and the Behavioural Facilitation System (BFS). Specifically, we will investigate the relationship between circadian control of the heart and the induction and quality of sleep, and the circadian influence on aspects of personality (neuroticism) and mood (Positive Affect) that are related to the BFS.Read moreRead less
Improving asthma device use: Innovative models for inter-professional practice. This project falls within the goals of National Priority 2: promoting and maintaining good health. This project has the potential to affect every individual accessing health care in the Australia. Through its approach to and focus on improving the use of asthma medications this project will impact on: the quality use of medicines and health outcomes for patients. Through its focus on health professional relationships ....Improving asthma device use: Innovative models for inter-professional practice. This project falls within the goals of National Priority 2: promoting and maintaining good health. This project has the potential to affect every individual accessing health care in the Australia. Through its approach to and focus on improving the use of asthma medications this project will impact on: the quality use of medicines and health outcomes for patients. Through its focus on health professional relationships and interdisciplinary approach to community health care it will result in: improved interprofessional relationships and a model of collaboration which has the potential to be implemented on a broad scale in the community.Read moreRead less
Common synaptic inputs to human upper airway muscles. Changes in the activity of upper airway muscles at sleep onset contribute to the development of Obstructive Sleep Apnoea. The aim of this project is to investigate how the brain controls upper airway muscles during wakefulness and sleep and to identify the pathological processes that lead to the development of Obstructive Sleep Apnoea.
Age and Gender Related Changes in Motor Control of the Upper Airway Muscle Genioglossus During Sleep. Obstructive Sleep Apnoea (OSA) is the repetitive obstruction of the airway during sleep. Obstructions occur because muscles of the upper airway fail to keep the airway open during inspiration. The disorder is associated with cardiovascular disease and cognitive and behavioural impairment. The prevalence of the disorder increases in older adults, contributing to age-related health and behavioural ....Age and Gender Related Changes in Motor Control of the Upper Airway Muscle Genioglossus During Sleep. Obstructive Sleep Apnoea (OSA) is the repetitive obstruction of the airway during sleep. Obstructions occur because muscles of the upper airway fail to keep the airway open during inspiration. The disorder is associated with cardiovascular disease and cognitive and behavioural impairment. The prevalence of the disorder increases in older adults, contributing to age-related health and behavioural problems. However, age-related changes differ in men and women. We believe the high prevalence of OSA in older adults is due to age and gender related changes in the activity of muscles in the upper airway. We will study the behaviour of the upper airway muscle genioglossus during sleep in young, middle-aged and older men and women.Read moreRead less
Empathy, Attention and Reasoning: The role of automatic and controlled processing in emotion recognition following traumatic brain injury. Traumatically brain injured adults have difficulty identifying emotional facial expressions but little is known regarding their psychophysiological reactions to emotional expression, the efficacy of their visual search patterns of facial features or the extent to which they engage conscious processing and problem solving to assist interpretation. Nor is anyth ....Empathy, Attention and Reasoning: The role of automatic and controlled processing in emotion recognition following traumatic brain injury. Traumatically brain injured adults have difficulty identifying emotional facial expressions but little is known regarding their psychophysiological reactions to emotional expression, the efficacy of their visual search patterns of facial features or the extent to which they engage conscious processing and problem solving to assist interpretation. Nor is anything known about their ability to recognise dynamic emotional displays compared to photographs. This project examines each of these facets using static and dynamic portrayals. The project will inform neuropsychological theories of facial processing, test the ecological validity of previous research and improve understanding of psychosocial deficits after TBI and their treatment.Read moreRead less
Hemispheric asymmetry of motor and language representation: Effects of hand preference and mirror movements. The neuroscience community has recently exploited advances in brain imaging to understand cerebral representation of many cognitive functions. The proposed study will expand our knowledge of brain-behaviour relationships, another key area of cognitive neuroscience research. Its successful funding and completion will increase Australia's standing as a major contributor to world research ou ....Hemispheric asymmetry of motor and language representation: Effects of hand preference and mirror movements. The neuroscience community has recently exploited advances in brain imaging to understand cerebral representation of many cognitive functions. The proposed study will expand our knowledge of brain-behaviour relationships, another key area of cognitive neuroscience research. Its successful funding and completion will increase Australia's standing as a major contributor to world research outcomes in this innovative and important field, and place Australia at its forefront. The investigator's access to advanced brain imaging and to the unique population of individuals with mirror movements, combined with expertise and experience in neuropsychology and brain imaging, places the research in an internationally competitive position.Read moreRead less
Exploring the brain mechanisms underlying hyperactivity in Attention-Deficit/Hyperactivity Disorder. Attention-deficit/Hyperactivity Disorder (AD/HD) is the most common psychiatric disorder affecting children, resulting in substantial costs (both human and financial) to the child, their family and Australian society. The outcomes of this project will provide a better foundation for understanding dysfunctional brain mechanisms in AD/HD, which is expected to lead to better diagnosis, treatment, an ....Exploring the brain mechanisms underlying hyperactivity in Attention-Deficit/Hyperactivity Disorder. Attention-deficit/Hyperactivity Disorder (AD/HD) is the most common psychiatric disorder affecting children, resulting in substantial costs (both human and financial) to the child, their family and Australian society. The outcomes of this project will provide a better foundation for understanding dysfunctional brain mechanisms in AD/HD, which is expected to lead to better diagnosis, treatment, and community support. Ultimately this will contribute to a healthy start to life for these children. This project will also demonstrate how an integrated Australian approach can lead the research agenda in both basic neuroscience, at the interface of psychology and physiology, and its applications in health.Read moreRead less
Central nervous system cytokines and morphine analgesia. Morphine remains the drug of choice for the management of moderate-to-severe pain, however its clinical effectiveness is compromised by the fact that morphine's analgesic (pain reducing) efficacy becomes less effective the more it is administered.. This project will examine how analgesic tolerance develops from a completely new approach: Namely, how stimulation of the immune system within the central nervous system is a crucial factor in t ....Central nervous system cytokines and morphine analgesia. Morphine remains the drug of choice for the management of moderate-to-severe pain, however its clinical effectiveness is compromised by the fact that morphine's analgesic (pain reducing) efficacy becomes less effective the more it is administered.. This project will examine how analgesic tolerance develops from a completely new approach: Namely, how stimulation of the immune system within the central nervous system is a crucial factor in the development of tolerance. Modulation of analgesia by the immune system has not been systematically studied and provides a potentially fertile ground for the development of new techniques in the management of clinical pain.Read moreRead less