The Role Of Nuclear Architecture In The DNA Damage Response
Funder
National Health and Medical Research Council
Funding Amount
$561,966.00
Summary
The goal of the proposed research is to understand how dynamic changes to the chromatin genome packaging network, interact with the DNA damage response and gene expression machinery, to repair damaged DNA and the impact this has on cancer biology. To do so we are combining cutting edge molecular biology techniques with innovative novel microscopy methods developed by our research team, that far exceed the spatiotemporal resolution currently used to study chromatin biology.
How Replication Stress Activates The Mitotic Telomere DNA Damage Response To Kill Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$486,467.00
Summary
We discovered a novel mechanism linking stress during DNA replication to difficulties with the cell division process, and identified how this turns on DNA damage response signals from the chromosome ends (i.e. “telomeres”). We have further identified that we can exploit this mechanism to kill cancer cells. In this project we will explore this newly discovered mechanism and identify how it can be targeted for therapeutic purposes.
All-solid-state Z-scheme photocatalysts for water treatment. The project aims to develop high-performance Z-scheme photocatalysts by using two-dimensional (2D) semiconductors as building blocks for low-cost, highly-efficient pathogen inactivation and emerging pollutant degradation in stormwater treatment. The project expects to generate new fundamental knowledge in the area of photocatalyst design and Z-scheme photocatalytic system, and advance the application of photocatalytic oxidation in wate ....All-solid-state Z-scheme photocatalysts for water treatment. The project aims to develop high-performance Z-scheme photocatalysts by using two-dimensional (2D) semiconductors as building blocks for low-cost, highly-efficient pathogen inactivation and emerging pollutant degradation in stormwater treatment. The project expects to generate new fundamental knowledge in the area of photocatalyst design and Z-scheme photocatalytic system, and advance the application of photocatalytic oxidation in water treatment. The expected outcomes of the project include novel 2D Z-scheme photocatalysts and enhanced capacity in stormwater management.Read moreRead less
Cold catalysis for water splitting. This project aims to develop photocatalysts via AC magnetic field through nanoscale heating for efficient H2 generation. This project is to introduce cold catalysis concept, which heats catalysts only but not solution, thus called cold catalysis, in the area of production of renewable energy. Expected outcome is the creation of clean and low cost catalysts to effectively harvest the chemical energy from the sun via splitting of water into H2 and O2 without cau ....Cold catalysis for water splitting. This project aims to develop photocatalysts via AC magnetic field through nanoscale heating for efficient H2 generation. This project is to introduce cold catalysis concept, which heats catalysts only but not solution, thus called cold catalysis, in the area of production of renewable energy. Expected outcome is the creation of clean and low cost catalysts to effectively harvest the chemical energy from the sun via splitting of water into H2 and O2 without causing any environmental damage. This unique technology will also help to address clean energy generation, which is in line with H2 economy plan by Australia government, and provide opportunities for new industries that will benefit Australian economy.Read moreRead less
Special Research Initiatives - Grant ID: SR180100023
Funder
Australian Research Council
Funding Amount
$940,000.00
Summary
Thermal decomposition of PFAS. This project aims to investigate the thermal decomposition of per- and poly-fluroalkyl substances (PFAS). The project will focus on the catalytic destruction of PFAS reactions at elevated temperatures, which is expected to transform PFAS in a controlled and predictable way into benign products. By understanding the fate of these compounds during thermal decomposition, the project will allow the development of a new technology aimed at treating materials which have ....Thermal decomposition of PFAS. This project aims to investigate the thermal decomposition of per- and poly-fluroalkyl substances (PFAS). The project will focus on the catalytic destruction of PFAS reactions at elevated temperatures, which is expected to transform PFAS in a controlled and predictable way into benign products. By understanding the fate of these compounds during thermal decomposition, the project will allow the development of a new technology aimed at treating materials which have been contaminated with or have been used as absorbants for PFAS. The project will provide the technical underpinning of a new technology developed to treat fluorochemical-contaminated material and, in doing so, reduce the environmental impact of these contaminants.Read moreRead less
Catalytic production of health food additives from crustacean wastes. Cost-effective production of new synthetic amino acids as value-added food additives from crustacean wastes is vital for waste recycling and a sustainable economy. This project will develop a unique catalytic system for the selective conversion of waste-derived compounds into tailor-made products. Advanced in situ spectroscopic techniques will be employed to establish the structure-reactivity relationship of working catalysts ....Catalytic production of health food additives from crustacean wastes. Cost-effective production of new synthetic amino acids as value-added food additives from crustacean wastes is vital for waste recycling and a sustainable economy. This project will develop a unique catalytic system for the selective conversion of waste-derived compounds into tailor-made products. Advanced in situ spectroscopic techniques will be employed to establish the structure-reactivity relationship of working catalysts and thereby manipulate the key factors governing the activity/selectivity. Such cutting-edge knowledge gained is crucial for optimising process effciency and resource utilisation, which is essential for the success of the biorefining industry and a more environmentally-friendly chemical and food economy in Australia.Read moreRead less
Nanoscale heating towards high efficient nitrogen reduction reduction. This project aims to develop nanoscale heating technique using AC magnetic field for efficient synthesis of ammonia, widely used for fertiliser and having potential for hydrogen storage. This project is to introduce nanoscale heating concept by heating catalyst only but not solution in electrochemical catalysis to achieve high catalytic activity. Expected outcome is the creation of low cost catalysts having high selectivity a ....Nanoscale heating towards high efficient nitrogen reduction reduction. This project aims to develop nanoscale heating technique using AC magnetic field for efficient synthesis of ammonia, widely used for fertiliser and having potential for hydrogen storage. This project is to introduce nanoscale heating concept by heating catalyst only but not solution in electrochemical catalysis to achieve high catalytic activity. Expected outcome is the creation of low cost catalysts having high selectivity and formation rate for ammonia production. This unique technology has the potential to replace current ammonia production based on Haber-Bosch process, which consumes 2% of world energy and contributes 3% of overall CO2 emission. The project provides opportunities for new industries that will benefit Australian economy.Read moreRead less
Deciphering The Role Of Atypical DNA Methylation In Neuronal Genome Regulation And Neurological Disorders
Funder
National Health and Medical Research Council
Funding Amount
$773,484.00
Summary
This research will use a combination of genomic, biochemical and functional genomics approaches to investigate the role of the atypical mCH form of DNA methylation in neuronal genome regulation and function, and provide new insights into the role of the epigenome in healthy brain function and neural pathologies.
Epigenetic Changes In The Prostate Cancer Microenvironment
Funder
National Health and Medical Research Council
Funding Amount
$848,954.00
Summary
Many men with prostate cancer have slow-growing tumours that are unlikely to spread outside the prostate. These men with low-risk cancer are often monitored to prevent unnecessary aggressive treatments. However, the current methods used to distinguish between slow-growing and aggressive tumours are imprecise and there is a risk of missing aggressive tumours. We aim to identify new biomarkers of prostate cancer by measuring modifications to the DNA in the tumour and surrounding cells
Circulating Tumour DNA To Monitor Treatment Response And Resistance In Chronic Lymphocytic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$876,950.00
Summary
Many cancers shed small amounts of DNA (ctDNA) into the patient’s bloodstream and recent advances in genomic technologies now allow levels of ctDNA to be accurately measured in the blood. Changes in ctDNA levels have potential to be used as specific markers of disease progression and/or response to cancer therapy. This project will evaluate if ctDNA can be used to monitor treatment responses and individualise treatment decisions in patients with chronic lymphocytic leukaemia.