20 Year Study Of Skin Cancer In A Queensland Community
Funder
National Health and Medical Research Council
Funding Amount
$396,415.00
Summary
Skin cancers are by far the commonest cancers diagnosed in Australia. Even though it is known that sun exposure in excess causes skin cancers there are complexities about the causes, especially of basal cell carcinoma (BCC) -the major type of skin cancer- that are still not understood. Relative intensity of sun exposure and perhaps its timing with respect to age in life may well be critical factors. We aim to study these causes in very great detail by collating information that has been gathered ....Skin cancers are by far the commonest cancers diagnosed in Australia. Even though it is known that sun exposure in excess causes skin cancers there are complexities about the causes, especially of basal cell carcinoma (BCC) -the major type of skin cancer- that are still not understood. Relative intensity of sun exposure and perhaps its timing with respect to age in life may well be critical factors. We aim to study these causes in very great detail by collating information that has been gathered over a 20 year period in a community-based skin cancer study in Nambour, Qld as well as performing some laboratory tests on skin cancer tissue collected from participants. This 3-year project will enable the full realisation of the potential of this esource-20 years in the making- with its wealth of information for answering questions about skin cancer decelopment and preventability. It should finally provide us with a clearer rationale for 'prevention of skin cancer' than is currently available. In addition we shall assess the costs of treatment of skin cancer in general and for the individual, and how much preventive practices for skin cancer might save the health budget, by using the releavnt data collected from this community sample.Read moreRead less
Probing Developmental Causes Of Soft Tooth Enamel With Novel Mouse Models
Funder
National Health and Medical Research Council
Funding Amount
$470,112.00
Summary
Tooth decay is one of the most costly diseases in Australia and was recently called a national tragedy by the Prime Minister. The risk of decay increases if teeth don't harden properly in childhood. This project aims to clarify the causes of soft enamel and identify ways to prevent it. Two new test systems will be used to see how antibiotics and fluoride affect enamel hardening. Our findings will help the battle against tooth decay and guide the safe use of medicines in children.
Functional Genomic Analysis Of The Role Of P53 In Early Embryo Death After Assisted Reproductive Technologies (ART).
Funder
National Health and Medical Research Council
Funding Amount
$227,036.00
Summary
Assisted reproductive technologies (ART, such as IVF and related techniques) are successful treatments for most forms of infertility. ART are expensive therapies and much of this cost is related to the relative inefficiency of the technology. Much of this is due to the high mortality of the resulting embryos. Typically, 45-80% of embryos produced by ART do not survive the first week. Consequently the chance of any individual embryo resulting in a successful birth is not high. There has been only ....Assisted reproductive technologies (ART, such as IVF and related techniques) are successful treatments for most forms of infertility. ART are expensive therapies and much of this cost is related to the relative inefficiency of the technology. Much of this is due to the high mortality of the resulting embryos. Typically, 45-80% of embryos produced by ART do not survive the first week. Consequently the chance of any individual embryo resulting in a successful birth is not high. There has been only modest increments in embryo survival in recent years. The low cahnce of individual embryos resulting in a baby means that: (1) generally several treatment cycles are required; (2) superovulation is used to maximise the number of embryos produced giving an accumulation of unwanted cryopreserved embryos; (3) more than one embryo is generally transferred resulting in a significant incidence of multiple pregancies. The high mortality of the early embryo seems to be a general feature of IVF but its causes and effectors are not known. It has recently been established that it largely occurs due to a form of cell 'suicide' known as apoptosis. This form of cell death has important normal functions: its activation allows for cells that are no longer required to be removed, allowing the remodelling of tissues and it also serves to remove cells that are irreversibly damaged. p53 is a protein that has the ability to 'sense' cell stress and damage and to direct the cell to undergo apoptosis if the stress is severe. This project will examine if ART cause increased expression of p53 and whether this elevation of p53 causes embryonic cell death. We will examine the factirs that control p53 expression in the embryo. using mice with mutations that stop the function of p53 and several of its regulatory proteins. Experiments will determine the susceptibility of embryos possessing these mutations and will therefore allow us to define the proteins causing apoptosis after ART.Read moreRead less
Mortality, Morbidity And Income Inequality In Australia
Funder
National Health and Medical Research Council
Funding Amount
$232,175.00
Summary
Evidence has been accumulating for some time indicates that an individual's life expectancy is affected by their socioeconomic circumstances. In general, it appears that people with higher incomes tend to live longer. More recently, some evidence has suggested that life expectancy is affected not only by a person's income level but also by their relative position in the income distribution. Some studies have found that, when income is more unequally distributed, mortality rates tend to be higher ....Evidence has been accumulating for some time indicates that an individual's life expectancy is affected by their socioeconomic circumstances. In general, it appears that people with higher incomes tend to live longer. More recently, some evidence has suggested that life expectancy is affected not only by a person's income level but also by their relative position in the income distribution. Some studies have found that, when income is more unequally distributed, mortality rates tend to be higher and life expectancy lower. Several explanations for this association have been advanced. One is that the association is a statistical artifact. Another is social-psychological, arguing that a sense of relative deprivation and social exclusion increases susceptibility to a variety of conditions. A third explanation is couched in terms of social capital, a term that refers to various forms of participation in voluntary organisations which strengthen community life. A fourth argues that it is material deprivation that is the underlying cause - income inequality is found in communities characterised by lower levels of provision of social infrastructure such as schools, libraries, and health services. The main purpose of this research project is to investigate the association between morbidity, mortality, income, and income inequality in Australia. The project will attempt to find which of the several explanations just discussed are supported by Australian evidence. The results of the project will enhance our understanding of the relationship between socioeconomic status and health, and will have implications for the design of different policies aimed at ameliorating the effects of income inequality on health.Read moreRead less
The presenilin proteins are key components in the development of Alzheimer's disease. Mutations in these proteins can cause early Alzheimer's disease. We will continue our study of the biochemistry and cell biology of these proteins using tools and experimental models that we have already developed. This will provide important information on the mechanism of the disease process and give new leads in the treatment of the disease. The new technologies of genetic screening for presenilin mutations ....The presenilin proteins are key components in the development of Alzheimer's disease. Mutations in these proteins can cause early Alzheimer's disease. We will continue our study of the biochemistry and cell biology of these proteins using tools and experimental models that we have already developed. This will provide important information on the mechanism of the disease process and give new leads in the treatment of the disease. The new technologies of genetic screening for presenilin mutations will be developed and utilized as a National referral base.Read moreRead less
The Future Of Tobacco Control: Exploring The Feasibility, Acceptability And Cost-effectiveness Of New Policy Directions
Funder
National Health and Medical Research Council
Funding Amount
$495,752.00
Summary
We will examine the practical feasibility, ethical and public acceptability, and likely cost effectiveness of a number of different ways of reducing tobacco smoking and the harm caused by smoking in Australia. These policy options will include: (1) more restrictive policies towards tobacco products (such as prohibiting tobacco smoking and creating a government monopoly on the manufacture and supply of tobacco); (2) encouraging smokers to switch from smoking cigarettes to less harmful ways of usi ....We will examine the practical feasibility, ethical and public acceptability, and likely cost effectiveness of a number of different ways of reducing tobacco smoking and the harm caused by smoking in Australia. These policy options will include: (1) more restrictive policies towards tobacco products (such as prohibiting tobacco smoking and creating a government monopoly on the manufacture and supply of tobacco); (2) encouraging smokers to switch from smoking cigarettes to less harmful ways of using nicotine, such as using nicotine patches or gum ; (3) using new biotechnologies to improve smokers chances of quitting (e.g. genetic screening of smokers to select the most effective way of helping them to stop smoking and vaccinating ex-smokers against the effects of nicotine); and (4) new biotechnologies that may prevent nonsmokers from beginning to smoke (e.g. vaccinating nonsmokers against the effects of nicotine) or reduce the chances of their developing tobacco-related diseases (e.g. screening the population for genes that predict an increased susceptibility to nicotine dependence and tobacco-related diseases). The project will provide important information that will assist government in formulating policies to reduce the rate of cigarette smoking in the Australian population below current levels.Read moreRead less
Improving Adherence With The Use Of Hip Protectors, In Community, Residential Aged Care And Hospital Settings
Funder
National Health and Medical Research Council
Funding Amount
$405,250.00
Summary
Hip protectors are plastic shields or foam pads worn over the hip in specially adapted underwear. A number of studies in older people have shown that hip protectors are very effective if worn when a fall occurs and these have been available for the last few years in Australia. Unfortunately it has been difficult for older people to wear the hip protectors reliably and because of limited compliance with their use they have not been fully effective. This study will compare provision of a brochure, ....Hip protectors are plastic shields or foam pads worn over the hip in specially adapted underwear. A number of studies in older people have shown that hip protectors are very effective if worn when a fall occurs and these have been available for the last few years in Australia. Unfortunately it has been difficult for older people to wear the hip protectors reliably and because of limited compliance with their use they have not been fully effective. This study will compare provision of a brochure, with supply of the older person's choice of hip protectors , with or without cost, and with or without contact with a nurse who will assist with use of the hip protector. After six months the level of use of the hip protectors will be checked. The new strategies tested in this study may increase compliance with hip protectors to a level where they will be effective if used at home in the community, in residential aged care facilities, and in hospitals.Read moreRead less
A Dual Antigen Synthetic Peptide Subunit Vaccine Approach To Prevent Streptococcal Associated Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$604,017.00
Summary
Infection with streptococcus is responsible for causing more than 500,000 deaths each year, the majority of which are due to rheumatic fever and rheumatic heart disease, which contributes to cardiovascular disease. Our research is aimed at the development of a vaccine to prevent heart disease and involves targeting multiple molecules present on the bacterial surface. We will use a novel vaccine delivery system developed in the laboratory, which will enable the vaccine to be delivered nasally.