Investigating The Novel Role Of SEPS1 In The Prevention Of Islet Beta Cell Failure And Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$535,804.00
Summary
SEPS1 is an important glucose-regulated protein whose function is to protect tissues from oxidative stress. Inhibition of SEPS1 by hyperglycaemia, is a mechanism for progression of Type 1 and Type 2 diabetes once hyperglycaemia supervenes. The overall aim of the project is to investigate the function of the novel SEPS1, using transgenic and knockout approaches.
A Novel Role For Alzheimer Tau Protein In Insulin Secretion And Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$1,023,712.00
Summary
There is a strong association between type 2 diabetes and Alzheimer's disease, however the reason for this is not known. In Azheimer's disease a protein called tau does not function normally and contributes to the declining cognitive function. We have shown that when tau is absent, this lowers blood glucose and reduces the hallmark defects that contribute to type 2 diabetes. By understanding how tau works we may be able to provide better therapeutic agents to treat type 2 diabetes.
Paediatric Validating Injury Burden Estimates Study (VIBES-Junior)
Funder
National Health and Medical Research Council
Funding Amount
$484,562.00
Summary
Injury is a leading cause of death and disability in children and adolescents, and can have lifelong effects for survivors. This study will quantify how well children recover from injury, and how long this takes, to establish better measures of the population impact of injury sustained in childhood and adolescence. The findings will be used to inform future health and social policy concerning primary prevention of injury in childhood and adolescence and the provision of services after injury.
The Healthy Brain Project: A Prospective Cohort Study To Examine How Later-life University Education May Affect The Trajectory Of Ageing-related Cognitive Decline
Funder
National Health and Medical Research Council
Funding Amount
$1,085,742.00
Summary
Previous research has indicated that higher levels of education in early adulthood are associated with lower risk for dementia in older adults. This world-first project will examine if older adults who undertake university education have reduced rates of age-related cognitive decline than older adults who do not undertake further education. This would support the notion that boosting cognitive reserve in later life is protective against age- and disease-related neurodegenerative change.
Lipidomic Analysis Of The FIELD Trial: Mechanism Of Action And Prediction Of Response To Fenofibrate Treatment In Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$643,323.00
Summary
Patients with type 2 diabetes have abnormal blood lipids leading to an increased risk of cardiovascular disease. This risk can be decreased by fenofibrate treatment. However, not all patients show the same response to fenofibrate and so it is not clear who will benefit and who will not benefit from treatment. In this project we will develop a test to identify those patients who respond to and benefit from fenofibrate treatment. This will lead to the better outcomes for patients.
Evidence For Action To Improve The Health Of Urban Aboriginal Children And Adolescents: The SEARCH Study
Funder
National Health and Medical Research Council
Funding Amount
$2,877,467.00
Summary
The proposed project builds on the Study of Environment on Aboriginal Resilience and Child Health (SEARCH), a cohort study of >1600 children and their families based on a long-standing Aboriginal Community Controlled Health Sector and research partnership. The project aims to improve urban Aboriginal child and adolescent health by using data from participants to identify opportunities for intervention and developing data-driven multicomponent interventions to improve health services.
Longitudinal Investigation Of Health Outcomes In Urban Aboriginal Children: SEARCH Follow-up
Funder
National Health and Medical Research Council
Funding Amount
$2,675,557.00
Summary
The government is committed to reducing the gap in Aboriginal health. SEARCH is Australia’s largest prospective longitudinal study of urban Aboriginal children and will provide, for the first time, comprehensive information on the causes of health and illness in a large group of urban Aboriginal children. SEARCH is a partnership with Aboriginal Community Controlled Health Services. SEARCH will identify the factors that can be changed in early childhood to prevent later disease.
PlaTFORM: PrevenTing Falls In A High Risk, Vision Impaired Population Through Specialist ORientation And Mobility Services: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$773,768.00
Summary
While many older people fall causing injury and loss of confidence, people with vision impairment and blindness have a dramatically increased risk of falls. In the PlaTFORM study we will deliver and comprehensively evaluate a falls prevention program through instructors with specialised training in orientation and mobility. This fills a gap in services and if effective will prevent injury in this vulnerable population and promote mobility.
The ASPREE-fracture Sub-study: Does Daily Low-dose Aspirin Reduce Fracture Risk In Healthy Older Adults?
Funder
National Health and Medical Research Council
Funding Amount
$1,351,150.00
Summary
Disability, mortality and healthcare burden from fractures in older people is a growing problem worldwide. This is despite decades of clinical research, best practice guidelines and advances in therapies that aim to reduce fracture risk. The World Health Organization has identified fracture prevention as a public health priority. This study will determine whether a widely available, simple and inexpensive health intervention—aspirin—can reduce the incidence of fracture and associated disability ....Disability, mortality and healthcare burden from fractures in older people is a growing problem worldwide. This is despite decades of clinical research, best practice guidelines and advances in therapies that aim to reduce fracture risk. The World Health Organization has identified fracture prevention as a public health priority. This study will determine whether a widely available, simple and inexpensive health intervention—aspirin—can reduce the incidence of fracture and associated disability amongst older Australians.Read moreRead less
Effectiveness Of An Ambient Intelligence Geriatric Management System (AmbIGeM) To Prevent Falls In Older People In Hospitals: The AmbIGeM Stepped Wedge Randomised Trial.
Funder
National Health and Medical Research Council
Funding Amount
$1,649,946.00
Summary
Falls are common in hospitals, especially among older patients and those with cognitive impairment. We will investigate if our newly developed ambience intelligence geriatric management system (AmbiGeM), which recognises when patients are undertaking risky movements related to increased risk of falling (e.g. walking without a necessary aid), and alerts staff so that they could offer help earlier, could reduce the number of falls in hospitals and is acceptable to staff and patients and/or carers.