Role of Musashi in the regulation of cell cycle proteins. We have identified a protein family that directs cell fate and maintains male fertility. This project will provide new avenues for generation of contraceptives in male animals and to regulate stem cells for production of specialised cell types in biotechnological applications.
New quantum and robust control theory with applications to quantum optics. The application of quantum mechanics to the creation of quantum technology promises to be one of the most exciting technological developments of this century. Possible applications of quantum technologies include vastly improved sensors to search for minerals or gravity waves, secure quantum cryptography, and quantum computing. Quantum feedback control is a key tool in quantum technology. This project will lay the fou ....New quantum and robust control theory with applications to quantum optics. The application of quantum mechanics to the creation of quantum technology promises to be one of the most exciting technological developments of this century. Possible applications of quantum technologies include vastly improved sensors to search for minerals or gravity waves, secure quantum cryptography, and quantum computing. Quantum feedback control is a key tool in quantum technology. This project will lay the foundations of systematic theories of robust, coherent and nonlinear quantum feedback control and lead to advances in the control of highly resonant systems which underlie experimental quantum and nano technology. This will enable Australia to reap great benefits as this new technological area emerges.Read moreRead less
Control of network systems with signed dynamical interconnections. New technologies such as online recommendations, smart grids, and cyber-physical systems are becoming backbone infrastructure. Such systems are operated as network systems with interconnected functioning units (agents) where cooperative and adversarial agent relations often coexist. This project aims to develop the theories and tools for designing and building dynamic networks with signed interactions that arise from a variety of ....Control of network systems with signed dynamical interconnections. New technologies such as online recommendations, smart grids, and cyber-physical systems are becoming backbone infrastructure. Such systems are operated as network systems with interconnected functioning units (agents) where cooperative and adversarial agent relations often coexist. This project aims to develop the theories and tools for designing and building dynamic networks with signed interactions that arise from a variety of applications where both cooperative and adversarial agent interactions coexist. By developing theories and algorithms for control and identification over such systems, this project will contribute directly to their safe and robust operation. The resulting theories will provide deeper understanding of network control systems and the resulting algorithms will enable the elimination of attackers and malicious users for online review systems and smart grids. This project will contribute to increased cybersecurity for all Australians.Read moreRead less
Generalised Energy Based Robust and Nonlinear Control Systems. This project aims to develop new energy-based theories of robust stability analysis and controller design for both linear and nonlinear systems, building on passivity and negative imaginary system theories and their physical interpretations along with stochastic optimal control theory. These control theories would allow for a wide range of plant dynamics in the design of high-performance robust control systems, enabling advances in e ....Generalised Energy Based Robust and Nonlinear Control Systems. This project aims to develop new energy-based theories of robust stability analysis and controller design for both linear and nonlinear systems, building on passivity and negative imaginary system theories and their physical interpretations along with stochastic optimal control theory. These control theories would allow for a wide range of plant dynamics in the design of high-performance robust control systems, enabling advances in emerging technologies including nanopositioning, micro-electromechanical systems and opto-mechatronics. The project plans to combine these theoretical advances with numerical methods involving advanced optimisation tools and the experimental implementation of nanopositioning control systems in atomic force microscopy.Read moreRead less
Optimisation methods for coherent quantum signal estimation and filtering. The project aims to develop an innovative systems theory and optimisation methods to enhance the design of components for next-generation quantum communication networks. It will advance new theoretical knowledge and efficient algorithms that can be applied to make networks more efficient and less costly. New technologies set to emerge within the next decade including specialised quantum processors and transformative cyber ....Optimisation methods for coherent quantum signal estimation and filtering. The project aims to develop an innovative systems theory and optimisation methods to enhance the design of components for next-generation quantum communication networks. It will advance new theoretical knowledge and efficient algorithms that can be applied to make networks more efficient and less costly. New technologies set to emerge within the next decade including specialised quantum processors and transformative cyber security systems will require ultra-fast networks, and the project will contribute significantly to advancing these technologies. This will benefit the Australia's economy and reinforce Australia's leadership in the quantum technological revolution through innovative engineering approaches.Read moreRead less
Cellular signals controlling oocyte activation. This research will significantly advance our understanding of the basic biological processes that underpin the fertility rate of all mammals and are key to the immediate and future health and well-being of Australian landscape and society. Understanding the processes that maintain healthy quiescent oocytes over many years before activation and subsequent growth will enable development of methods of increasing productivity in domestic animals and en ....Cellular signals controlling oocyte activation. This research will significantly advance our understanding of the basic biological processes that underpin the fertility rate of all mammals and are key to the immediate and future health and well-being of Australian landscape and society. Understanding the processes that maintain healthy quiescent oocytes over many years before activation and subsequent growth will enable development of methods of increasing productivity in domestic animals and enhancing fertility in endangered species. Knowledge of these cellular mechanisms will underpin biotechnology platforms necessary for novel methods of feral animal population control thus contributing at multiple levels to an economically sustainable Australia.Read moreRead less
A unified model of amino acid homeostasis. This project aims to develop a unified model of amino acid homeostasis in mammalian cells and apply it to brain cells. The model will be underpinned by a mathematical algorithm that allows predicting amino acid levels in the cytosol based on fundamental parameters such as transport and metabolism. This project should provide the significant benefit of enabling the prediction of essential functions such as cell growth and survival.
Spatially distributed complex multiagent systems. This project will develop design methodologies for two related classes of technological systems: wireless sensor networks (in particular mobile sensor networks) and formations of mobile robotic agents. These technologies find application today in defence, and will probably become pervasive in the civilian sector.
Discovering how termites use vibrations to make foraging decisions. Termites are pests affecting one third of Australian homes. The annual cost of treatment and damage repair is over $20 billion worldwide. Yet, little is known about how termites make foraging decisions based on vibrations. This project will study the key features in vibration signals produced by termites to unlock the secrets of their foraging behaviour.
Stabilisation of nonlinear quantum feedback control systems. One of the most exciting technological developments of this century promises to be the development of quantum technology. Quantum feedback systems will play a key part of this technology and this project will develop the underlying fundamental theory which will be crucial to the systematic design of quantum feedback control systems.