Role of Musashi in the regulation of cell cycle proteins. We have identified a protein family that directs cell fate and maintains male fertility. This project will provide new avenues for generation of contraceptives in male animals and to regulate stem cells for production of specialised cell types in biotechnological applications.
Accelerated Finite-time Learning and Control in Cyber-Physical Systems. Efficient learning and control in cyber-physical systems such as smart grids and robotic systems are very important for achieving economic and social benefits. This project aims to establish a breakthrough accelerated finite-time dynamics theory and technology to assist in delivering efficient learning and control. Expected outcomes include new distributed accelerated finite-time dynamics based learning and control algorithm ....Accelerated Finite-time Learning and Control in Cyber-Physical Systems. Efficient learning and control in cyber-physical systems such as smart grids and robotic systems are very important for achieving economic and social benefits. This project aims to establish a breakthrough accelerated finite-time dynamics theory and technology to assist in delivering efficient learning and control. Expected outcomes include new distributed accelerated finite-time dynamics based learning and control algorithms and tools for optimal operations in cyber-physical systems. This should provide significant benefits including a practical technology for industry applications in smart grids and robotic systems, and training of the next generation engineers in this technology for Australia.Read moreRead less
Protecting Occupants in Vehicle Rollover Crashes. This project addresses a public health issue involving rollover crashes. It will help prevent 340 deaths, 6000 injuries and save $3.6 billion annually in Australia and many fold this number internationally. A dynamic rollover crashworthiness test protocol, that ensures efficient and economical vehicle rollover protection systems are designed and manufactured, will be provided to consumer and regulatory bodies to consider and implement. In additio ....Protecting Occupants in Vehicle Rollover Crashes. This project addresses a public health issue involving rollover crashes. It will help prevent 340 deaths, 6000 injuries and save $3.6 billion annually in Australia and many fold this number internationally. A dynamic rollover crashworthiness test protocol, that ensures efficient and economical vehicle rollover protection systems are designed and manufactured, will be provided to consumer and regulatory bodies to consider and implement. In addition, much needed Occupational Health & Safety information regarding vehicle rollover crashworthiness, which provide a safe work place environment for professional drivers and employees using vehicles, will be supplied to industry fleet managers, defence and emergency services.Read moreRead less
Non-contact Integrity Assessment of Façade Panels of High-rise Buildings. Disintegration of the external façade (with tiles, plates, etc.) of high-rise buildings presents a great challenge and a threat to community. This project develops fundamental knowledge and algorithms that underpin the deployment of a new technique for fast and automated quantitative integrity assessment of façade units of high-rise buildings, integrating mechanisms of directional acoustic waves, vibro-acoustics of façade ....Non-contact Integrity Assessment of Façade Panels of High-rise Buildings. Disintegration of the external façade (with tiles, plates, etc.) of high-rise buildings presents a great challenge and a threat to community. This project develops fundamental knowledge and algorithms that underpin the deployment of a new technique for fast and automated quantitative integrity assessment of façade units of high-rise buildings, integrating mechanisms of directional acoustic waves, vibro-acoustics of façade tiles or panels, laser sensing technology, deep learning algorithms and drone technology. Outcomes of this project are critical for implementing the new technology for enhanced safety to community and the development of new procedures for driving down maintenance costs of the external façade of high-rise buildings.Read moreRead less
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Regulation of Stress Hormone Receptors in the Brain. Our research will provide information on how the brain controls our response to stress and will allow the development of targeted strategies to reduce the possibility during chronic stress of the development of conditions such as anxiety and depression. This will improve mental health outcomes in Australia and add to Australia's economic and social stability.
Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cel ....Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cell migration with relevance to the basic biology of inflammation, repair and regeneration and new innovations for cell imaging. Significant benefits are expected to arise from this new knowledge and from advanced skills training and improved national capabilities in bio-imaging and analysis.Read moreRead less
The roles of stress and immunocompetence in biological invasions. Invasive species pose a major threat to biodiversity worldwide; and within Australia, cane toads are widely viewed as one of the biggest such problems. Building on recent studies that reveal weakened immune systems in invasion-front toads, this project will provide a comprehensive understanding of immune responses in cane toads and native frogs, with the aim of exploiting the toads' immunocompromised state to develop new and more ....The roles of stress and immunocompetence in biological invasions. Invasive species pose a major threat to biodiversity worldwide; and within Australia, cane toads are widely viewed as one of the biggest such problems. Building on recent studies that reveal weakened immune systems in invasion-front toads, this project will provide a comprehensive understanding of immune responses in cane toads and native frogs, with the aim of exploiting the toads' immunocompromised state to develop new and more effective control measures. The project will develop a new paradigm about the roles of stress and immunity in biological invasion, applicable to the control of other invasive species and to understanding processes at work when environmental changes force species to shift their ranges.Read moreRead less
Context-aware verification and validation framework for autonomous driving. This project aims to enhance the reliability and safety of emerging self-driving vehicles, through a framework that supports the validation and verification of autonomous driving systems. This project expects to generate new knowledge in areas of software engineering, intelligent transport, and machine learning, using a multi-disciplinary research combining expertise from various fields. Expected outcomes of this project ....Context-aware verification and validation framework for autonomous driving. This project aims to enhance the reliability and safety of emerging self-driving vehicles, through a framework that supports the validation and verification of autonomous driving systems. This project expects to generate new knowledge in areas of software engineering, intelligent transport, and machine learning, using a multi-disciplinary research combining expertise from various fields. Expected outcomes of this project are a family of new context-aware techniques to verify and validate complex behaviours in autonomous driving. This should provide significant benefits, such as safe autonomous driving systems and the improved journey experience and security for road users.Read moreRead less
Elucidating the mechanisms of mitochondrial DNA escape. The human body is powered by mitochondria, microscopic components of living cells that make the energy they need to function. Mitochondrial damage is linked to a wide spectrum of human diseases, from devastating syndromic illnesses to neurodegeneration and autoimmunity. This project is focused on 1) how stresses such as cancer therapy or infection cause mitochondrial damage, and 2) understanding the biological processes that are triggered i ....Elucidating the mechanisms of mitochondrial DNA escape. The human body is powered by mitochondria, microscopic components of living cells that make the energy they need to function. Mitochondrial damage is linked to a wide spectrum of human diseases, from devastating syndromic illnesses to neurodegeneration and autoimmunity. This project is focused on 1) how stresses such as cancer therapy or infection cause mitochondrial damage, and 2) understanding the biological processes that are triggered inside the cell as it tries to recover. It will give a much greater understanding of mitochondrial damage at the microscopic level, and has the potential to unlock new avenues of investigation into the causes of inflammatory and immune disorders.Read moreRead less