Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already i ....Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already in the country by providing predictive tools to estimate likelihood of spread. For formal Pest Risk Analysis by regulators (eg Biosecurity Australia), our project will provide genomic tools by which the potential weediness of a regulated plant can be assessed through genetic screening, and forms part of an international effort to identify 'weedy genes'. Read moreRead less
Cell-free immune reactions and suppression. Insects pests and insect vectors of diseases are managed by toxic substances, but insects have a cunning ability to persist. How pesticide-tolerant insect pests recognise and inactivate chemical and biological toxins is poorly understood. While vertebrates with a closed circulatory system use coagulation reactions mainly for wound-healing, invertebrates employ cell-free aggregation reactions for the sequestration and inactivation of potentially damagin ....Cell-free immune reactions and suppression. Insects pests and insect vectors of diseases are managed by toxic substances, but insects have a cunning ability to persist. How pesticide-tolerant insect pests recognise and inactivate chemical and biological toxins is poorly understood. While vertebrates with a closed circulatory system use coagulation reactions mainly for wound-healing, invertebrates employ cell-free aggregation reactions for the sequestration and inactivation of potentially damaging objects and substances. We use insect plasma to dissect recognition and inactivation of damaging objects and substances with the aim to understand tolerance and its inhibition to design novel strategies in delaying tolerance to pesticides in insect pests.Read moreRead less
Addressing significant product safety knowledge gaps for older Australians . This project addresses significant gaps in contemporary knowledge of consumer product safety risks for older persons, with 25 years since the last Australian product safety research found older persons are at high risk of product-related injury/death. Products have evolved substantially and aged care models have changed in that time. This project generates contemporary knowledge of unsafe products causing injuries/death ....Addressing significant product safety knowledge gaps for older Australians . This project addresses significant gaps in contemporary knowledge of consumer product safety risks for older persons, with 25 years since the last Australian product safety research found older persons are at high risk of product-related injury/death. Products have evolved substantially and aged care models have changed in that time. This project generates contemporary knowledge of unsafe products causing injuries/deaths, risk factors/behaviours, and human rights issues. Outcomes benefiting the Australian community are improved prediction/characterisation of product safety issues for older Australians informing safer product design and use, targetted regulatory responses, ageing-in-place strategies, and creating safer home environments.Read moreRead less
The fundamental equations for inversion of operator pencils. This project seeks to deepen understanding of how complex systems may be significantly changed by incremental changes to ambient conditions. Mathematical models of complex systems (climate change processes, optimal driving strategies, efficient distribution policies, effective search routines) often depend on key parameters. If small perturbations to the parameters cause large changes to the solution, then the perturbations are said to ....The fundamental equations for inversion of operator pencils. This project seeks to deepen understanding of how complex systems may be significantly changed by incremental changes to ambient conditions. Mathematical models of complex systems (climate change processes, optimal driving strategies, efficient distribution policies, effective search routines) often depend on key parameters. If small perturbations to the parameters cause large changes to the solution, then the perturbations are said to be singular. This project aims to reveal the underlying mathematical structures and develop new computational algorithms to analyse a general class of perturbed systems both locally near an isolated singularity and globally. It plans to use these algorithms to solve systems of equations, calculate generalised inverse operators, examine perturbed Markov processes, and estimate exit times from meta-stable states in stochastic population dynamics.Read moreRead less
Unravelling the principles of bilateral brain wiring. This project seeks to investigate the molecular principles of brain wiring in mammals and how small changes can generate complex outcomes. Neurons in the mammalian brain must be precisely wired together for the brain to function correctly. The project aims to identify the molecular and cellular rules governing commissural wiring in the mammalian cortex to determine how the largest fibre tract in the human brain, the corpus callosum, evolved. ....Unravelling the principles of bilateral brain wiring. This project seeks to investigate the molecular principles of brain wiring in mammals and how small changes can generate complex outcomes. Neurons in the mammalian brain must be precisely wired together for the brain to function correctly. The project aims to identify the molecular and cellular rules governing commissural wiring in the mammalian cortex to determine how the largest fibre tract in the human brain, the corpus callosum, evolved. This may have involved modifications in mechanisms affecting axon guidance that differ between placentals and marsupials. The project investigates the regulatory gene networks determining commissural neuron fate, the regulation of axon guidance components, and the influence of surrounding brain tissue on the development of commissural connections.Read moreRead less
Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations t ....Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations that optimise plant yield and fitness will be defined and explored in other, more complex, cereals such as wheat. Expected outcomes will be fundamental breakthroughs in understanding how plants respond to, and buffer, the effects of heat to lead to translational breeding strategies that bolster grain yield.Read moreRead less
Evaluating consumer product regulatory responses to improve child safety. This project aims to quantify the level of similarity between consumer product regulatory practices and child injuries, and compare national approaches. Consumer product safety regulation operates in a global and ‘virtual’ market. Online purchasing, limited border protection and distance between suppliers and consumers make monitoring and enforcing product safety more difficult for regulators, putting consumers at risk. A ....Evaluating consumer product regulatory responses to improve child safety. This project aims to quantify the level of similarity between consumer product regulatory practices and child injuries, and compare national approaches. Consumer product safety regulation operates in a global and ‘virtual’ market. Online purchasing, limited border protection and distance between suppliers and consumers make monitoring and enforcing product safety more difficult for regulators, putting consumers at risk. A rapid responsive product safety system that operates across sectors and borders is an international priority. This project expects to close gaps in consumer regulatory practice and safety policy.Read moreRead less
Safer gene editing tools for Australian livestock and biotech industries. Editing the genome of an organism in an efficient and safe fashion is critical for the livestock and biotechnology industries. While CRISPR-Cas9 has become the method of choice for genome editing, it is known to introduce unwanted "on-target" and "off-target" mutations, limiting its utility. To address this the CI team created a novel genome editing platform technology termed Crackling-CAST that is almost 100% accurate, w ....Safer gene editing tools for Australian livestock and biotech industries. Editing the genome of an organism in an efficient and safe fashion is critical for the livestock and biotechnology industries. While CRISPR-Cas9 has become the method of choice for genome editing, it is known to introduce unwanted "on-target" and "off-target" mutations, limiting its utility. To address this the CI team created a novel genome editing platform technology termed Crackling-CAST that is almost 100% accurate, while retaining the efficiency of the classical Cas9 system. This project will exemplify the capabilities of the novel gene targeting platform in cell types used by the biotechnology and livestock sectors, ensuring its global uptake by these industries and delivering significant economic benefits for Australia. Read moreRead less