Role of Musashi in the regulation of cell cycle proteins. We have identified a protein family that directs cell fate and maintains male fertility. This project will provide new avenues for generation of contraceptives in male animals and to regulate stem cells for production of specialised cell types in biotechnological applications.
New quantum and robust control theory with applications to quantum optics. The application of quantum mechanics to the creation of quantum technology promises to be one of the most exciting technological developments of this century. Possible applications of quantum technologies include vastly improved sensors to search for minerals or gravity waves, secure quantum cryptography, and quantum computing. Quantum feedback control is a key tool in quantum technology. This project will lay the fou ....New quantum and robust control theory with applications to quantum optics. The application of quantum mechanics to the creation of quantum technology promises to be one of the most exciting technological developments of this century. Possible applications of quantum technologies include vastly improved sensors to search for minerals or gravity waves, secure quantum cryptography, and quantum computing. Quantum feedback control is a key tool in quantum technology. This project will lay the foundations of systematic theories of robust, coherent and nonlinear quantum feedback control and lead to advances in the control of highly resonant systems which underlie experimental quantum and nano technology. This will enable Australia to reap great benefits as this new technological area emerges.Read moreRead less
ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology indust ....ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology industry, the protection of the Australian Environment and the well-being of the Australian people. Key issues for this Centre include testicular cancer, male infertility, contraception, pest animal control, environmental impacts on human health and gene pharming.Read moreRead less
Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less
Generalised Energy Based Robust and Nonlinear Control Systems. This project aims to develop new energy-based theories of robust stability analysis and controller design for both linear and nonlinear systems, building on passivity and negative imaginary system theories and their physical interpretations along with stochastic optimal control theory. These control theories would allow for a wide range of plant dynamics in the design of high-performance robust control systems, enabling advances in e ....Generalised Energy Based Robust and Nonlinear Control Systems. This project aims to develop new energy-based theories of robust stability analysis and controller design for both linear and nonlinear systems, building on passivity and negative imaginary system theories and their physical interpretations along with stochastic optimal control theory. These control theories would allow for a wide range of plant dynamics in the design of high-performance robust control systems, enabling advances in emerging technologies including nanopositioning, micro-electromechanical systems and opto-mechatronics. The project plans to combine these theoretical advances with numerical methods involving advanced optimisation tools and the experimental implementation of nanopositioning control systems in atomic force microscopy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453295
Funder
Australian Research Council
Funding Amount
$369,697.00
Summary
NMR cryosystem for structural and functional biology. State-of-the-art hardware is requested for the 600-MHz NMR spectrometers situated at University of Sydney and UNSW. A cryosystem installed at USyd. will provide a massive boost in productivity and will allow projects previously inaccessible due to excessive turn-around times, or sensitivity or solubility problems to become tractable. This system will provide new opportunities to researchers from USyd., UNSW and ANU, but will restrict the ver ....NMR cryosystem for structural and functional biology. State-of-the-art hardware is requested for the 600-MHz NMR spectrometers situated at University of Sydney and UNSW. A cryosystem installed at USyd. will provide a massive boost in productivity and will allow projects previously inaccessible due to excessive turn-around times, or sensitivity or solubility problems to become tractable. This system will provide new opportunities to researchers from USyd., UNSW and ANU, but will restrict the versatility of the USyd. instrument. The installation of a TBI probe at UNSW will counter this, and provide a REAL network of NMR instruments across NSW and the ACT.Read moreRead less
Safety in the Heavy Vehicle Industry: A Collaborative Response. The management and regulation of heavy vehicles, particularly in relation to safety, is recognised as an urgent issue at all levels of government across Australia. In the absence of research that identifies the key determinants of heavy vehicle crashes, countermeasures will continue to be based on anecdote. The proposed study will determine the role key risk factors, namely scheduling and sleep-related factors, play in heavy vehicl ....Safety in the Heavy Vehicle Industry: A Collaborative Response. The management and regulation of heavy vehicles, particularly in relation to safety, is recognised as an urgent issue at all levels of government across Australia. In the absence of research that identifies the key determinants of heavy vehicle crashes, countermeasures will continue to be based on anecdote. The proposed study will determine the role key risk factors, namely scheduling and sleep-related factors, play in heavy vehicle crashes and will identify cost-effective strategies to reduce the growing economic burden associated with these crashes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102873
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Securing networked control and estimation systems and safeguarding critical infrastructure. The purpose of this project is to reduce the likelihood of success, and the severity of impact, of a cyber-attack against networked control and estimation systems operating within critical infrastructure. The outcome will be a suite of algorithms, tools and design considerations for networked, industrial, control systems that satisfy this purpose.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989084
Funder
Australian Research Council
Funding Amount
$275,000.00
Summary
Confocal Laser Scanning Microscopy for Live Cell Imaging. The University of Newcastle has invested heavily in its biological and life sciences to create a research nexus focusing on national research priorities in biotechnology and environmental protection. The Live Cell Imaging platform will be utilized by scientists researching such strategically important areas including developmental biology, intracellular signalling cascades, cell cycle dynamics, plant development and microbiology. Moreover ....Confocal Laser Scanning Microscopy for Live Cell Imaging. The University of Newcastle has invested heavily in its biological and life sciences to create a research nexus focusing on national research priorities in biotechnology and environmental protection. The Live Cell Imaging platform will be utilized by scientists researching such strategically important areas including developmental biology, intracellular signalling cascades, cell cycle dynamics, plant development and microbiology. Moreover, this component of the University's research portfolio plays a major role in the postgraduate training of young Australian scientists who will, in turn, fuel future developments in both the life sciences and biotechnology industries.Read moreRead less
Power systems with diverse generation - implications, control and capability. This research will generate a systematic methodology to handle the impact of the renewable energy sources on the NSW power grid. It increases our understanding of the impact of climate change policies relating to mandatory targets for greenhouse gas reduction helping to build Australia’s research capacity in the national priority area of an environmentally sustainable Australia. The anticipated methodology can also be ....Power systems with diverse generation - implications, control and capability. This research will generate a systematic methodology to handle the impact of the renewable energy sources on the NSW power grid. It increases our understanding of the impact of climate change policies relating to mandatory targets for greenhouse gas reduction helping to build Australia’s research capacity in the national priority area of an environmentally sustainable Australia. The anticipated methodology can also be seen as protecting the security of power infrastructure as well. Maintaining a critical energy infrastructure protects our way of life and ensures ongoing social, economic and environmental well being of Australia.Read moreRead less