Optimal Control Computation and Analysis of Switched Systems with State and Control Constraints. DC/DC converters are widely used in power supply systems and hybrid power systems generate cleaner energy. Achieving optimum performance in these applications has high commercial and environmental impacts. New optimal control problems for such practical problems will be formulated and new unified optimization theory and methods for these optimal control problems will be obtained. The outcomes will en ....Optimal Control Computation and Analysis of Switched Systems with State and Control Constraints. DC/DC converters are widely used in power supply systems and hybrid power systems generate cleaner energy. Achieving optimum performance in these applications has high commercial and environmental impacts. New optimal control problems for such practical problems will be formulated and new unified optimization theory and methods for these optimal control problems will be obtained. The outcomes will enhance Australia's reputation in this cutting edge research, and contribute to achieving optimal performance of high commercial and environmental value applications. It will also facilitate international collaboration, and provide an excellent opportunity for research training.Read moreRead less
Fluorine-labelled proteins for NMR spectroscopy. The technique developed in this project has direct impact on pharmaceutical research: NMR spectroscopy is used routinely to identify chemical compounds that bind to protein targets. This project includes the development of novel assignment techniques of 19F-labelled proteins, so that 19F-NMR can be used to detect specific binding interactions. One of the methods proposed here is designed to reveal structural information about the binding mode in s ....Fluorine-labelled proteins for NMR spectroscopy. The technique developed in this project has direct impact on pharmaceutical research: NMR spectroscopy is used routinely to identify chemical compounds that bind to protein targets. This project includes the development of novel assignment techniques of 19F-labelled proteins, so that 19F-NMR can be used to detect specific binding interactions. One of the methods proposed here is designed to reveal structural information about the binding mode in solution with atomic detail. This knowledge can significantly accelerate drug development. It is otherwise only available from crystal structures that can not always be determined.Read moreRead less