Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaire ....Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaired but must be developed to identify the causes of decline. The intended outcomes are improved sustainable water resource management within and among states, and improved natural resource policy development.Read moreRead less
ARC Centre of Excellence in Plants for Space. ARC Centre of Excellence in Plants for Space. This Centre aims to create on-demand, zero-waste, high-efficiency plants and plant products to address grand challenges in sustainability for Space and on Earth. Significant advances in plant, food, and sensory science; process and systems engineering; law and policy; and psychology are expected to deliver transformative solutions for Space habitation – and create enhanced plant-derived food and bioresour ....ARC Centre of Excellence in Plants for Space. ARC Centre of Excellence in Plants for Space. This Centre aims to create on-demand, zero-waste, high-efficiency plants and plant products to address grand challenges in sustainability for Space and on Earth. Significant advances in plant, food, and sensory science; process and systems engineering; law and policy; and psychology are expected to deliver transformative solutions for Space habitation – and create enhanced plant-derived food and bioresources to capitalise upon emergent and rapidly expanding domestic and global markets. Anticipated outcomes include industry uptake of innovative plant forms, foods, technologies, and commodities; and an ambitious education and international co-ordination agenda to position Australia as a global leader in research supporting Space habitation.Read moreRead less
Biogeochemical remediation approaches for PFAS contaminated environments. This project aims to identify and harvest microorganisms capable of directly or indirectly affecting PFOS or PFOA degradation in the environment. Fluorinated compounds such as PFOS and PFOA in firefighting foams are contaminants of concern now routinely detected in contaminated groundwater and soil globally. Understanding the role of microorganisms, and the biogeochemical processes they perform in relation to fluorinated c ....Biogeochemical remediation approaches for PFAS contaminated environments. This project aims to identify and harvest microorganisms capable of directly or indirectly affecting PFOS or PFOA degradation in the environment. Fluorinated compounds such as PFOS and PFOA in firefighting foams are contaminants of concern now routinely detected in contaminated groundwater and soil globally. Understanding the role of microorganisms, and the biogeochemical processes they perform in relation to fluorinated compounds, will inform handling of contaminated sites and lead to development of cost effective and sustainable remediation technologies. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0221983
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Interface, Particle and Complex Fluid Characterisation Laboratory. This laboratory will provide a state-of-the-art characterisation facility for complex fluids. This will service the needs of 27 research staff and 38 postgraduate students and involve collaboration between twelve major research groups based at the Universities of Melbourne, Newcastle, Monash, La Trobe and RMIT. The facility will enhance the research activities of the collaborating institutions in key strategic areas. The laborat ....Interface, Particle and Complex Fluid Characterisation Laboratory. This laboratory will provide a state-of-the-art characterisation facility for complex fluids. This will service the needs of 27 research staff and 38 postgraduate students and involve collaboration between twelve major research groups based at the Universities of Melbourne, Newcastle, Monash, La Trobe and RMIT. The facility will enhance the research activities of the collaborating institutions in key strategic areas. The laboratory will also act as a facility for undertaking consulting projects with industry groups by the applicants.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100088
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A coupled high temperature elemental analyser - gas chromatograph - mass spectrometer for climate, water and ecological research. A coupled high temperature elemental analyser - gas chromatograph - mass spectrometer for climate, water and ecological research: This project is for a high temperature, elemental analysis, gas chromatography, isotope mass spectrometry facility. This would permit the analysis of the isotopes of up to four elements in a range of environmental samples such as tree cell ....A coupled high temperature elemental analyser - gas chromatograph - mass spectrometer for climate, water and ecological research. A coupled high temperature elemental analyser - gas chromatograph - mass spectrometer for climate, water and ecological research: This project is for a high temperature, elemental analysis, gas chromatography, isotope mass spectrometry facility. This would permit the analysis of the isotopes of up to four elements in a range of environmental samples such as tree cellulose, ecological samples and dissolved nutrients in surface and ground waters. Results will help improve our understanding of climate - surface water - ground water interactions, ecosystem function, and past climate and environmental change. The new facility will meet the need for organic isotope analyses to better understand the underlying physical processes.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC160100027
Funder
Australian Research Council
Funding Amount
$4,340,802.00
Summary
ARC Training Centre for Biopharmaceutical Innovation. ARC Training Centre for Biopharmaceutical Innovation. This centre aims to transform Australia’s growing biopharmaceutical industry, an advanced manufacturing capability, by training specialist biotechnologists and bioengineers. It expects the research and development outputs will create new biopharmaceuticals and antibody-based reagents, enhanced production methods, improved manufacturing capabilities and a cohort of specialist scientists. Ne ....ARC Training Centre for Biopharmaceutical Innovation. ARC Training Centre for Biopharmaceutical Innovation. This centre aims to transform Australia’s growing biopharmaceutical industry, an advanced manufacturing capability, by training specialist biotechnologists and bioengineers. It expects the research and development outputs will create new biopharmaceuticals and antibody-based reagents, enhanced production methods, improved manufacturing capabilities and a cohort of specialist scientists. New biopharmaceuticals are expected to benefit the Australian economy and provide new therapeutic options for better health outcomes. Industry-driven research projects will also provide industry-ready graduates who can drive future growth in the sector.Read moreRead less
Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cel ....Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cell migration with relevance to the basic biology of inflammation, repair and regeneration and new innovations for cell imaging. Significant benefits are expected to arise from this new knowledge and from advanced skills training and improved national capabilities in bio-imaging and analysis.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH220100017
Funder
Australian Research Council
Funding Amount
$4,808,669.00
Summary
ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals. Radiopharmaceuticals are emerging as next generation medical technologies for addressing complex health challenges, and their manufacture offers significant economic benefit to Australia. The ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR) aims to establish a manufacturing platform for new medical technologies combining innovations in biotechnology and pharmaceutical science. The progra ....ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals. Radiopharmaceuticals are emerging as next generation medical technologies for addressing complex health challenges, and their manufacture offers significant economic benefit to Australia. The ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR) aims to establish a manufacturing platform for new medical technologies combining innovations in biotechnology and pharmaceutical science. The program addresses industry-led challenges for translation of biologics as molecular radiopharmaceuticals, building capacity in biomanufacturing, radiobiology and radiochemistry. The program establishes a dedicated manufacturing pipeline, future-proofing production and securing supply chain of next generation medical technologies.Read moreRead less