Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less
The Role Of Melanoma Tumour Antigen P97 (Melanotransferrin) In Melanoma Tumourigenesis.
Funder
National Health and Medical Research Council
Funding Amount
$563,242.00
Summary
The Role of Melanoma Tumour Antigen p97 (Melanotransferrin) in Melanoma Tumourigenesis Melanotransferrin (MTf) is a homologue of the iron transport protein, transferrin, and was one of the first well characterised melanoma tumour antigens. Our published studies have shown that MTf plays an important role in melanoma tumourigenesis in vivo. In this proposal, we will assess if it is associated with melanoma progression in patient samples and examine its role in melanoma growth and metastasis.
Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less
Developing A Smart Farming Oriented Secure Data Infrastructure. Smart farming is the future of agriculture. However, recently the Federal Bureau of Investigation has issued a
warning that the lack of data privacy and cyber security mechanisms in the field runs a high risk of disaster. This
project aims to establish an innovative secure data infrastructure for smart farming including secure and automated smart farming supply-chain management. The deliverables of this project will include the cutt ....Developing A Smart Farming Oriented Secure Data Infrastructure. Smart farming is the future of agriculture. However, recently the Federal Bureau of Investigation has issued a
warning that the lack of data privacy and cyber security mechanisms in the field runs a high risk of disaster. This
project aims to establish an innovative secure data infrastructure for smart farming including secure and automated smart farming supply-chain management. The deliverables of this project will include the cutting-edge Blockchain based secure IoT data management and privacy-preserving smart contracts for smart farming supply-chain management. This data infrastructure will be the first of its kind which will lay a solid foundation for smart farming technology.Read moreRead less
Privacy-preserving Biometrics based Authentication and Security. Password based authentication systems cannot verify genuine users. Biometric authentication can address this issue. However, the booming IoT applications and cloud computing require that the biometric authentication must be conducted in the privacy-protected setting in order to comply with privacy protection legal regulations. Latest reports show that current biometric authentication systems, under protected setting, exhibit poor ....Privacy-preserving Biometrics based Authentication and Security. Password based authentication systems cannot verify genuine users. Biometric authentication can address this issue. However, the booming IoT applications and cloud computing require that the biometric authentication must be conducted in the privacy-protected setting in order to comply with privacy protection legal regulations. Latest reports show that current biometric authentication systems, under protected setting, exhibit poor authentication performance, which is not commercially applicable. This project aims to investigate innovative solutions to this issue. The intended deliverables will include deep learning based biometric feature extractor, cancellable biometrics and cloud oriented biometrics security protocols. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101081
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Adaptive value-flow analysis to improve code reliability and security. This project aims to develop client-driven adaptive value-flow analysis to detect software bugs in system software written in the C/C++ programme language. Static analysis tools for automated code inspections can benefit software developers, but are imprecise, inefficient and not user-friendly for analysing real-world industrial-sized software. The project will investigate static, dynamic and user-guided value-flow analysis t ....Adaptive value-flow analysis to improve code reliability and security. This project aims to develop client-driven adaptive value-flow analysis to detect software bugs in system software written in the C/C++ programme language. Static analysis tools for automated code inspections can benefit software developers, but are imprecise, inefficient and not user-friendly for analysing real-world industrial-sized software. The project will investigate static, dynamic and user-guided value-flow analysis to efficiently and precisely analyse large-scale programs according to clients’ needs, thereby allowing compilers to generate safe, reliable and secure code. This project is expected to advance value-flow analysis for industrial-sized software, improve software reliability and security, and benefit Australian software systems and industries.Read moreRead less
Learning to Pinpoint Emerging Software Vulnerabilities. This project aims to develop learning-based software vulnerability detection techniques to improve the reliability and security of modern software systems. The existing techniques relying on conventional yet rigid software analysis and testing techniques are ineffective and/or inefficient when detecting a wide variety of emerging software vulnerabilities. The outcomes of this project will be a deep-learning-based detection approach and an ....Learning to Pinpoint Emerging Software Vulnerabilities. This project aims to develop learning-based software vulnerability detection techniques to improve the reliability and security of modern software systems. The existing techniques relying on conventional yet rigid software analysis and testing techniques are ineffective and/or inefficient when detecting a wide variety of emerging software vulnerabilities. The outcomes of this project will be a deep-learning-based detection approach and an open-source tool that can capture precision correlations between deep code features and diverse vulnerabilities to pinpoint emerging vulnerabilities without the need for bug specifications. Significant benefits include greatly improved quality, reliability and security for modern software systems.Read moreRead less