New Polymers for Cellulose-based Bioplastics. We will design new cellulose derivatives by combining carefully engineered synthetic polymers to cellulose. We will explore the fundamental science underpinning the manufacture of these bioplastics, and apply the concept to the design of two new materials, with (super)hydrophobic and antibacterial properties. These materials have the potential to replace synthetic plastics, which comprise one of the major outputs of the chemical industry worldwide. P ....New Polymers for Cellulose-based Bioplastics. We will design new cellulose derivatives by combining carefully engineered synthetic polymers to cellulose. We will explore the fundamental science underpinning the manufacture of these bioplastics, and apply the concept to the design of two new materials, with (super)hydrophobic and antibacterial properties. These materials have the potential to replace synthetic plastics, which comprise one of the major outputs of the chemical industry worldwide. Plastic is present everywhere in human life, but its manufacture and disposal have a strong negative impact on the environment; the new materials manufactured in this project are viable alternatives to plastics, and are sustainable from a production and disposal point of view.Read moreRead less
Real-time imaging of crystal strengthening mechanisms in metals. The strength limit of a metal is marked by rapid motion of crystalline defects. The associated speeds can locally approach that of sound. To probe the associated mechanisms clearly requires both spatial and temporal resolution. We propose to create a new bulk x-ray technique with an unprecedented combination of temporal and spatial resolution. We plan to exploit the technique to mediate a step change in modelling strength based on ....Real-time imaging of crystal strengthening mechanisms in metals. The strength limit of a metal is marked by rapid motion of crystalline defects. The associated speeds can locally approach that of sound. To probe the associated mechanisms clearly requires both spatial and temporal resolution. We propose to create a new bulk x-ray technique with an unprecedented combination of temporal and spatial resolution. We plan to exploit the technique to mediate a step change in modelling strength based on twinning. The formation of crystalline twins is known to dictate the strength of the light metal magnesium. A fuller understanding of the effect of twinning on strength in this metal will provide much needed confidence to implement it more widely in energy saving applications.Read moreRead less
A Tough Resilin Based Hydrogel Platform for Repair and Regeneration. This project seeks to develop novel hydrogels that mimic the properties of the body. In the field of repair and regeneration, our challenge is to make hydrogels that retain the fatigue and resilience properties of the natural body part, but are comprised of nontoxic material. Resilin is a remarkable material exhibiting a broad range of stimuli-responsive behaviour and outstanding elasticity. The project aim is to create a tough ....A Tough Resilin Based Hydrogel Platform for Repair and Regeneration. This project seeks to develop novel hydrogels that mimic the properties of the body. In the field of repair and regeneration, our challenge is to make hydrogels that retain the fatigue and resilience properties of the natural body part, but are comprised of nontoxic material. Resilin is a remarkable material exhibiting a broad range of stimuli-responsive behaviour and outstanding elasticity. The project aim is to create a tough and responsive hydrogel platform from this disordered protein family through greater understanding of structure and mechanical function and incorporating adequate stiffness, strength and biocompatibility. Such tough hydrogels would be applicable to a range of biotechnological applications (eg intervertebral disc repair or artificial skin tissue engineering).Read moreRead less
Towards autonomous structural safety prognostics: integrating in-situ imaging and predictive modelling. This project aims to advance a scientific basis for autonomous safety prognostics by developing predictive models and in-situ damage imaging principles. Development of this new health prognostic approach will overcome the significant challenge of safety assurance of composite structures in the presence of in-service damage, which is largely hidden.
Baseline-free Methods for Early Damage Diagnosis using Nonlinear Ultrasound. To address the significant limitation of existing non-destructive evaluation techniques in detecting and characterising early damage, this project aims to discover the physical nature of self-generated nonlinear waves by structural damage and to explore its potential for an entirely new class of non-destructive evaluation and structural health monitoring techniques. Major applications are expected to include a baseline- ....Baseline-free Methods for Early Damage Diagnosis using Nonlinear Ultrasound. To address the significant limitation of existing non-destructive evaluation techniques in detecting and characterising early damage, this project aims to discover the physical nature of self-generated nonlinear waves by structural damage and to explore its potential for an entirely new class of non-destructive evaluation and structural health monitoring techniques. Major applications are expected to include a baseline-free structural health monitoring technique capable of detecting and quantifying barely-visible impact damage in advanced composite materials, non-destructive evaluation of structures made by additive manufacturing, and detection of hard-to-inspect locations in unitised structures.Read moreRead less
Revealing the atoms that control performance in photoactive perovskites. This project aims to develop new electron microscopy techniques that will unambiguously determine the elusive structures of photoactive perovskite compounds under static and operational conditions, while correlating crystal structure with solar cell device performance. Photoactive perovskites are promising photovoltaic materials, however, many are sensitive to air and irradiation. This has impeded a huge international resea ....Revealing the atoms that control performance in photoactive perovskites. This project aims to develop new electron microscopy techniques that will unambiguously determine the elusive structures of photoactive perovskite compounds under static and operational conditions, while correlating crystal structure with solar cell device performance. Photoactive perovskites are promising photovoltaic materials, however, many are sensitive to air and irradiation. This has impeded a huge international research effort to determine their structure reliably at the atomic scale. With these new techniques applied to leading compounds and devices, it is expected this project will reveal the structural effects controlling electrical properties and device performance and so enable the design of superior perovskite photovoltaics.Read moreRead less
Selectively targeting cancer and infectious disease with fragment-based drug discovery. Finding better compounds as starting points is one of the major challenges for drug discovery research. Fragments are small, weak binding molecules that can be upsized into drug leads with better properties when compared to starting with larger molecules. This project addresses two weaknesses of current fragment based drug discovery (FBDD) methods: first, the limitations associated with screening fragments; a ....Selectively targeting cancer and infectious disease with fragment-based drug discovery. Finding better compounds as starting points is one of the major challenges for drug discovery research. Fragments are small, weak binding molecules that can be upsized into drug leads with better properties when compared to starting with larger molecules. This project addresses two weaknesses of current fragment based drug discovery (FBDD) methods: first, the limitations associated with screening fragments; and second, the quality of commercial fragment libraries. This project anticipates that the findings will establish a commanding role for both mass spectrometry and three-dimensional fragments in advancing FBDD approaches. It also expects to identify fragments with favourable development prospects towards the next generation of therapeutics.Read moreRead less
Quantum microscopy meets photovoltaics: new tools for solar cell research. This project aims to create an innovative platform to characterise solar cells, based on recently developed quantum diamond microscopy. It will enable direct imaging of the current flow in operating photovoltaic devices, providing a new window into key processes such as charge collection and recombination. The platform will be applied to a range of industry-relevant photovoltaic materials and devices. Anticipated outcomes ....Quantum microscopy meets photovoltaics: new tools for solar cell research. This project aims to create an innovative platform to characterise solar cells, based on recently developed quantum diamond microscopy. It will enable direct imaging of the current flow in operating photovoltaic devices, providing a new window into key processes such as charge collection and recombination. The platform will be applied to a range of industry-relevant photovoltaic materials and devices. Anticipated outcomes include new insights into recombination processes and the effect of device degradation, which could facilitate optimisation of the power conversion efficiency and reliability of next-generation solar cells. Additional benefits include new instruments and methods that may find use in the solar cell manufacturing industry.Read moreRead less
Synchrotron X-ray absorption fine structure and fundamental X-ray interactions for nano-physics, chemistry and mineralogy. This project will develop new synchrotron techniques for measuring and interpreting X-ray data from materials targeting the nano-environment and bonding. The first wave of synchrotron nanotechnology is nascent. The project's X-ray methods develop techniques in applied mineralogy and catalysis. New insight will address key questions in chemistry, mining and biology.
Nanoparticle inks for electronic applications employing nanostructured thin-films. The development of next-generation technologies requires careful engineering of materials at the nanoscale. Using nanoparticle inks, many of the engineering difficulties which exist at these length scales can be overcome, thus allowing for technologies such as thin-film solar cells to become cheaper and more efficient.