Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100218
Funder
Australian Research Council
Funding Amount
$840,000.00
Summary
A Nuclear Magnetic Resonance Facility for Modern Molecular Analysis. A nuclear magnetic resonance facility for modern molecular analysis:
This project aims to network a new 500 MHz nuclear magnetic resonance (NMR) spectrometer and new consoles for existing instruments with an automated sample changer for a 600 MHz NMR spectrometer. This designed to increase the capacity of Queensland-based researchers to undertake state-of-the-art studies in chemistry, drug design, and materials science. The ne ....A Nuclear Magnetic Resonance Facility for Modern Molecular Analysis. A nuclear magnetic resonance facility for modern molecular analysis:
This project aims to network a new 500 MHz nuclear magnetic resonance (NMR) spectrometer and new consoles for existing instruments with an automated sample changer for a 600 MHz NMR spectrometer. This designed to increase the capacity of Queensland-based researchers to undertake state-of-the-art studies in chemistry, drug design, and materials science. The new knowledge from these studies may lead to the development of new drugs, new crop protection agents and new photovoltaic materials. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120103152
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Development of next generation drugs against Helicobacter pylori. Gastric cancer is the second leading cause of cancer-related death in the world and infection by Helicobacter pylori bacteria is the main cause of this disease. The aim of this project is to develop new approaches to treat Helicobacter pylori infection that will give superior results and lower side effects than available therapies.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100148
Funder
Australian Research Council
Funding Amount
$1,350,000.00
Summary
Advanced Nuclear Magnetic Resonance Technologies for Southeast Queensland. This project aims to establish an advanced Nuclear Magnetic Resonance capability and capacity at two of Queenslands' leading research intensive universities. The project expects to enhance the scope and productivity of hundreds of research projects spanning natural products, synthetic, medicinal, materials and environmental science. Expected outcomes include smarter science, more productive collaborations and superior res ....Advanced Nuclear Magnetic Resonance Technologies for Southeast Queensland. This project aims to establish an advanced Nuclear Magnetic Resonance capability and capacity at two of Queenslands' leading research intensive universities. The project expects to enhance the scope and productivity of hundreds of research projects spanning natural products, synthetic, medicinal, materials and environmental science. Expected outcomes include smarter science, more productive collaborations and superior research training, leading to innovative solutions to challenging problems that confront science and society. This investment should provide significant benefits in the form of new knowledge across multiple disciplines, informing the design of future medicines, agrochemicals, materials and other products.
Read moreRead less
Novel conotoxins that target ion channels and receptors. This project will discover peptides from cone snail venom that are potential drug candidates. The project will expand our knowledge of these biological active peptides and their mode of action. It will also protect key molecules through patent applications, providing a competitive edge for Australian biotechnology.
Development of potent and specific modulators of the human sodium channel Nav1.7. There are few effective drugs available for the treatment of chronic pain. This team recently discovered that spider venoms are a rich source of inhibitors of Nav1.7, a new target for anti-pain drugs. The goal of this project is to develop potent blockers of Nav1.7 that can be used to critically assess the role of this ion channel in mediating pain.
Aquatic chemo-modulators: a novel source for potent molecular probes. This project aims to investigate peptides that modulate prey behaviour. Chemical signalling constitutes much of the language of life underwater. Certain cone snails evolved a hunting strategy, where they release potent peptides to modulate fish behaviour through yet unknown mechanisms. The snail then expands its mouth and eats the fish without resistance. This project will investigate the mechanisms at play using transcriptomi ....Aquatic chemo-modulators: a novel source for potent molecular probes. This project aims to investigate peptides that modulate prey behaviour. Chemical signalling constitutes much of the language of life underwater. Certain cone snails evolved a hunting strategy, where they release potent peptides to modulate fish behaviour through yet unknown mechanisms. The snail then expands its mouth and eats the fish without resistance. This project will investigate the mechanisms at play using transcriptomics, proteomics, peptide synthesis, behavioural pharmacology and nuclear magnetic resonance. This will advance the knowledge of aquatic chemo-modulators on a functional, structural and evolutionary level, and provide a source of molecular probes with unique pharmacology and applications in human physiology, developmental biology and aquacultures.Read moreRead less
Novel cysteine-rich conotoxin frameworks from Australian cone snails. This project aims to discover conotoxins that are potential drug leads or useful pharmacological tools. It aims to increase both the discovery of novel conotoxin cysteine-rich frameworks through integrated transcriptomics and proteomics (venomics), conotoxin synthesis and 3-D structure determination, and to generate conotoxin disulfide bond mimetics and conotoxin dendrimers to increase stability, potency and selectivity. The w ....Novel cysteine-rich conotoxin frameworks from Australian cone snails. This project aims to discover conotoxins that are potential drug leads or useful pharmacological tools. It aims to increase both the discovery of novel conotoxin cysteine-rich frameworks through integrated transcriptomics and proteomics (venomics), conotoxin synthesis and 3-D structure determination, and to generate conotoxin disulfide bond mimetics and conotoxin dendrimers to increase stability, potency and selectivity. The work is designed to be based on a venomics platforms to accelerate conotoxin framework discovery while using novel mimetics and dendrimeric constructs to improve their biophysical properties. The expected outcomes include an expansion of novel conotoxin sequences and novel frameworks to generate lead molecules for potential development.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100119
Funder
Australian Research Council
Funding Amount
$2,000,000.00
Summary
Regional nuclear magnetic resonance infrastructure network for South East Queensland and Northern New South Wales. Nuclear magnetic resonance infrastructure network: This project will provide support for a nuclear magnetic infrastructure network for use by researchers across five universities. The infrastructure will provide capability for small molecule-based research and will enable cutting-edge scientific collaborative research opportunities.
Exploring the novel structural features of influenza virus sialidase. The outcomes of this project will provide a deeper mechanistic understanding of influenza virus sialidase and the importance of the enzyme's flexible loops in carbohydrate recognition. Specifically, this project will improve our understanding of fundamental aspects of inhibitor binding by influenza virus sialidases.