Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develo ....Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develop innovative methods to investigate, and importantly modulate, DNA and RNA triple helix assembly, specificity and molecular interactions. Resulting insights will underpin novel approaches to gene regulation, principally in the context of designing new antibacterial agents to address the antibacterial resistance problem.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100135
Funder
Australian Research Council
Funding Amount
$880,000.00
Summary
An ion mobility-mass spectrometry based platform for structural proteomics. This project aims to establish a nationally unique facility dedicated to structural proteomics, combining high resolution ion mobility mass spectrometry with advanced separation, hydrogen/deuterium exchange and imaging platforms. Such technology is critical to characterise 3D biomacromolecular structures, dynamics, interactions and spatial location on a proteome-wide scale, and overcome current analytical limitations for ....An ion mobility-mass spectrometry based platform for structural proteomics. This project aims to establish a nationally unique facility dedicated to structural proteomics, combining high resolution ion mobility mass spectrometry with advanced separation, hydrogen/deuterium exchange and imaging platforms. Such technology is critical to characterise 3D biomacromolecular structures, dynamics, interactions and spatial location on a proteome-wide scale, and overcome current analytical limitations for structure determination from complex biological samples, particularly for closely related (isomeric) components. Servicing a diverse research community, this will enable new molecular insights to better understand the natural world, and accelerate cutting edge biotechnology advances intersecting life and chemical sciences.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100139
Funder
Australian Research Council
Funding Amount
$1,240,000.00
Summary
Revitalizing facilities for nuclear magnetic resonance in South Australia. Nuclear magnetic resonance (NMR) spectroscopy is the single most powerful spectroscopic tool for determining molecular structure. Our aim is to upgrade NMR infrastructure available to researchers across South Australia with an integrated and complementary array of state-of-the-art spectrometers to diversify usage across a range of disciplines. Replacement of outdated spectrometers will modernise core NMR facilities along ....Revitalizing facilities for nuclear magnetic resonance in South Australia. Nuclear magnetic resonance (NMR) spectroscopy is the single most powerful spectroscopic tool for determining molecular structure. Our aim is to upgrade NMR infrastructure available to researchers across South Australia with an integrated and complementary array of state-of-the-art spectrometers to diversify usage across a range of disciplines. Replacement of outdated spectrometers will modernise core NMR facilities along with installation of new probes to improve sensitivity and the ability to analyze small sample quantities. Our overall strategy is to maximize capability and minimize duplication, while bringing South Australia's NMR capabilities up to a national and international standard. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100015
Funder
Australian Research Council
Funding Amount
$523,899.00
Summary
Integrated Tip-Enabled Nanofabrication and Characterisation at Atomic Scale. This project aims to establish the most advanced all-in-one multifunctional system going beyond the best system in the world. This facility is expected to combine tip-enabled nanofabrication, imaging, photo-/electrochemical, and electromechanical measurement to realise atomically precisely controlled nanofabrication, in-situ imaging, and real-time measurement of single active sites in micro and nanoscale devices.The pro ....Integrated Tip-Enabled Nanofabrication and Characterisation at Atomic Scale. This project aims to establish the most advanced all-in-one multifunctional system going beyond the best system in the world. This facility is expected to combine tip-enabled nanofabrication, imaging, photo-/electrochemical, and electromechanical measurement to realise atomically precisely controlled nanofabrication, in-situ imaging, and real-time measurement of single active sites in micro and nanoscale devices.The proposed facility features high-quality measurements in an unmatched spatial and temporal range, allowing studying physical and chemical phenomena that are difficult to detect using conventional methods. The proposed integrated system will be the first of its kind in Australia. Read moreRead less
Theory and methods for evaluation of microstructural fatigue damage. The microstructural damage accumulation stage often consumes a significant portion of the total fatigue life of structures. However, its progressive evaluation is beyond the reach of safety inspection techniques which are currently employed to maintain structural integrity and prevent fatigue failures. This project aims to fill this gap by developing innovative methods for the measurement of material properties related to fatig ....Theory and methods for evaluation of microstructural fatigue damage. The microstructural damage accumulation stage often consumes a significant portion of the total fatigue life of structures. However, its progressive evaluation is beyond the reach of safety inspection techniques which are currently employed to maintain structural integrity and prevent fatigue failures. This project aims to fill this gap by developing innovative methods for the measurement of material properties related to fatigue damage and establishing a new theory which links these properties to the remaining life of the structure. The project outcomes will facilitate the global trend towards predictive maintenance strategies, thereby generating substantial cost benefits, specifically, for high-value assets and ageing infrastructure.Read moreRead less
Next generation nondestructive inspection using guided-wave mixing. This project aims to develop a novel approach for early damage detection. It relies on a systematic experimental investigation of nonlinear ultrasonic interaction between different input wave modes in the presence of damage, so as to identify optimal mode selections and operating parameters that will maximise the sensitivity to particular forms of structural damage. The effects of in-service loading on wave-mixing response, and ....Next generation nondestructive inspection using guided-wave mixing. This project aims to develop a novel approach for early damage detection. It relies on a systematic experimental investigation of nonlinear ultrasonic interaction between different input wave modes in the presence of damage, so as to identify optimal mode selections and operating parameters that will maximise the sensitivity to particular forms of structural damage. The effects of in-service loading on wave-mixing response, and non-contact detection suitable for hard-to-inspect surface conditions, will also be investigated. The new developments will help transform existing schedule-based maintenance practice to a condition-based maintenance paradigm, to achieve significant cost savings in maintenance.Read moreRead less