Discovery Early Career Researcher Award - Grant ID: DE210100065
Funder
Australian Research Council
Funding Amount
$423,808.00
Summary
Designing Organocatalysts to Achieve Hyperpolarised Magnetic Resonance. Magnetic resonance techniques (such as MRI scans) suffer from an inherent insensitivity problem. In medical imaging, this can hamper diagnosis and mean long scan times for patients. This project aims to chemically develop catalysts which dramatically increase sensitivity, producing a signal that is thousands of times more visible. This project is significant as these catalysts can turn common, harmless molecules in the body ....Designing Organocatalysts to Achieve Hyperpolarised Magnetic Resonance. Magnetic resonance techniques (such as MRI scans) suffer from an inherent insensitivity problem. In medical imaging, this can hamper diagnosis and mean long scan times for patients. This project aims to chemically develop catalysts which dramatically increase sensitivity, producing a signal that is thousands of times more visible. This project is significant as these catalysts can turn common, harmless molecules in the body - even water - into visible tracers. The expected outcomes of this project include the synthesis and understanding of these catalysts which will be chemically fine-tuned to maximise their effectiveness. Potential benefits include translation to MRI applications to improve diagnosis and treatment, or chemical monitoring.Read moreRead less
Methods for Protein Structure Analysis by Electron Paramagnetic Resonance. This highly interdisciplinary project aims to establish new tools to analyse the structure and motions of proteins that are otherwise difficult to study. A combination of advanced biochemistry, modern magnetic spectroscopy methods, and high-performance computing techniques will be applied to study proteins at physiological concentrations and in complex environments. New techniques will be developed and tested on proteins ....Methods for Protein Structure Analysis by Electron Paramagnetic Resonance. This highly interdisciplinary project aims to establish new tools to analyse the structure and motions of proteins that are otherwise difficult to study. A combination of advanced biochemistry, modern magnetic spectroscopy methods, and high-performance computing techniques will be applied to study proteins at physiological concentrations and in complex environments. New techniques will be developed and tested on proteins of high biochemical or biomedical importance, and the approach will be applied to established drug targets.Read moreRead less
Molecular mechanisms of mechanosensation and shape regulation in cells. This project aims to explore how cells physically sense and respond to the surrounding environment on a molecular level. Physical distortion of erythrocytes doubles their glucose consumption and increases cation membrane flux five-fold. This mechanism involves opening of the mechanosenstive ion channel Piezo1. This project will include a kinetic description of these phenomena, with a goal to establish a predictive mathematic ....Molecular mechanisms of mechanosensation and shape regulation in cells. This project aims to explore how cells physically sense and respond to the surrounding environment on a molecular level. Physical distortion of erythrocytes doubles their glucose consumption and increases cation membrane flux five-fold. This mechanism involves opening of the mechanosenstive ion channel Piezo1. This project will include a kinetic description of these phenomena, with a goal to establish a predictive mathematical model of the regulation of cell-shape and volume. The project will provide an understanding of mechanisms operating when cells and tissues are succumbing to trauma and invasion, and how to control these processes on a molecular level.Read moreRead less
Novel source of excited metastable atoms for Atom Trap Trace Analysis. This project aims to understand and to control light-induced processes in atoms by using finely shaped and tailored laser pulses, focusing on efficient production of excited metastable atoms. This is critical for efficient Atom Trap Trace Analysis, the most advanced technique for dating ground water and geological samples. Expected outcomes of this project include new and enhanced knowledge of physics of light-matter interact ....Novel source of excited metastable atoms for Atom Trap Trace Analysis. This project aims to understand and to control light-induced processes in atoms by using finely shaped and tailored laser pulses, focusing on efficient production of excited metastable atoms. This is critical for efficient Atom Trap Trace Analysis, the most advanced technique for dating ground water and geological samples. Expected outcomes of this project include new and enhanced knowledge of physics of light-matter interactions, developing an efficient, clean source of excited metastable atoms, and integrating that source into the Australian National Facility for dating geological samples. This should provide significant benefits, such as significant improvement of operational efficiency and productivity of that facility.Read moreRead less
Nonlinear topological photonics . The rapidly growing demands of information processing have launched a race for compact optical devices transmitting signals without losses. Topological phases of light provides unique opportunities to create new photonic systems with functionalities and efficiencies well beyond current capabilities. This project aims to develop new ways to generate and guide light at the nanoscale by merging fundamental concepts of nonlinear photonics and topological physics. Th ....Nonlinear topological photonics . The rapidly growing demands of information processing have launched a race for compact optical devices transmitting signals without losses. Topological phases of light provides unique opportunities to create new photonic systems with functionalities and efficiencies well beyond current capabilities. This project aims to develop new ways to generate and guide light at the nanoscale by merging fundamental concepts of nonlinear photonics and topological physics. The outcomes of this project will result in experimental demonstration of the world-first, highly efficient, compact, and lossless nonlinear photonic devices for advanced optical technologies.Read moreRead less
Optical frequency conversion in nonlinear dielectric metasurfaces. This project aims to investigate the mixing of light colours in semiconductor nanocrystals arranged in an ultra-thin transparent film, called a nonlinear metasurface. Understanding of the resonant nonlinear interactions in such metasurfaces will allow for the up and down frequency conversion of light beams and images with efficiencies well beyond current capabilities. The outcomes of the project will form the basis for novel cost ....Optical frequency conversion in nonlinear dielectric metasurfaces. This project aims to investigate the mixing of light colours in semiconductor nanocrystals arranged in an ultra-thin transparent film, called a nonlinear metasurface. Understanding of the resonant nonlinear interactions in such metasurfaces will allow for the up and down frequency conversion of light beams and images with efficiencies well beyond current capabilities. The outcomes of the project will form the basis for novel cost-effective and compact devices for infrared imaging, and will also enable ultra-fast sources of quantum light with tailored spatial and spectral correlations. These will benefit important applications in defence and security, including night vision, security holograms, quantum cryptography and communications.Read moreRead less
Topological wave manipulation in hybrid integrated platforms. This project aims to establish a powerful toolkit for topological wave manipulation in photonic systems interfaced with layered 2D materials. This research will address a significant problem of miniaturising photonic components for reliable and compact signal processing. The reduction in size will be achieved by engineering coupling of topological photonic states with matter in judiciously structured materials at subwavelength scales. ....Topological wave manipulation in hybrid integrated platforms. This project aims to establish a powerful toolkit for topological wave manipulation in photonic systems interfaced with layered 2D materials. This research will address a significant problem of miniaturising photonic components for reliable and compact signal processing. The reduction in size will be achieved by engineering coupling of topological photonic states with matter in judiciously structured materials at subwavelength scales. The expected outcomes will include new methods of controlling light-matter waves on a chip via pattern distortions or twists of the 2D materials, without the use of strong magnetic and electric fields. These outcomes will benefit future development of high performance and energy-efficient integrated devices.Read moreRead less
Synthetic multi-dimensional integrated photonics. This project aims to develop and realise experimentally integrated circuits where light propagation mimics dynamics in arbitrarily complex imaginary photonic lattices. The project puts forward a universal and mass-fabrication compatible design concept of planar optical structures featuring unconventional synthetic multi-dimensional properties, which can also be reconfigured in real time. This underpins expected outcomes in optical detection with ....Synthetic multi-dimensional integrated photonics. This project aims to develop and realise experimentally integrated circuits where light propagation mimics dynamics in arbitrarily complex imaginary photonic lattices. The project puts forward a universal and mass-fabrication compatible design concept of planar optical structures featuring unconventional synthetic multi-dimensional properties, which can also be reconfigured in real time. This underpins expected outcomes in optical detection with fundamentally enhanced sensitivity and optical signal switching with ultra-low threshold. The benefits of such breakthrough improvements can have broad applications spanning from future optical communication networks to optical sensors for monitoring and health applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100679
Funder
Australian Research Council
Funding Amount
$436,775.00
Summary
Disruptive nanotechnology to control light. The project aims to develop approaches to control propagation of light in nonreciprocal ways, similar to ways we control directions of electric currents with semiconductor diodes and transistors. Nonreciprocal behaviour of light is difficult to achieve, and it is currently limited to relatively large optical systems, which represents a road block for further miniaturisation and integration of optical devices. Expected outcomes of this project include f ....Disruptive nanotechnology to control light. The project aims to develop approaches to control propagation of light in nonreciprocal ways, similar to ways we control directions of electric currents with semiconductor diodes and transistors. Nonreciprocal behaviour of light is difficult to achieve, and it is currently limited to relatively large optical systems, which represents a road block for further miniaturisation and integration of optical devices. Expected outcomes of this project include first demonstrations of a radical miniaturisation of nonreciprocal optical components to the nanoscale. The outcomes should enrich our fundamental knowledge and assist the advancement of vital technologies such as integrated optical circuitry and communication infrastructure.Read moreRead less