Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101044
Funder
Australian Research Council
Funding Amount
$444,318.00
Summary
Bio-inspired nanomaterials with tunable drug loading and controlled release. This project aims to develop new platform technologies for making bio-inspired nanomaterials with tunable drug loading and controlled release. This project will revolutionise current approaches to make lipid nanoparticles camouflaged with natural cell membranes for delivery of both insoluble and soluble drugs. Significant outcomes will include a novel commercially relevant salt-induced nanoprecipitation platform technol ....Bio-inspired nanomaterials with tunable drug loading and controlled release. This project aims to develop new platform technologies for making bio-inspired nanomaterials with tunable drug loading and controlled release. This project will revolutionise current approaches to make lipid nanoparticles camouflaged with natural cell membranes for delivery of both insoluble and soluble drugs. Significant outcomes will include a novel commercially relevant salt-induced nanoprecipitation platform technology for making precisely engineered nanomaterials with tailored functions for applications in controlled release and targeted delivery. Benefits include securing a sustainable future for Australia, with new nanotechnology strategies for advanced manufacturing.Read moreRead less
Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microflu ....Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties, a dual-templating method for making targeted silica nanocapsules and new design of in vivo-mimicking 'Tissue Chips' for screening and evaluating the nanocarriers.Read moreRead less
Tailoring physiologically-based nanomaterial fertilisers for the biofortification of zinc in broadacre crops. Soil zinc deficiency is a global issue causing low crop yield and malnutrition. This project will develop a new class of fertiliser formulations by combining advanced chemistry techniques with plant physiology knowledge and nanomaterial manufacturing. These products will be designed for enhanced agronomic efficiency and environmental safety.
Bioactive Polymer Platelets. This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailor ....Bioactive Polymer Platelets. This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailored towards bioactive and biocompatible material to create a drug delivery platform for more efficient disease treatment. The outcome will be better understanding on how polymer platelets can be obtained and how they compare in their biological activity with spherical nanoparticles.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101011
Funder
Australian Research Council
Funding Amount
$420,818.00
Summary
Developing advanced potassium-sulfur batteries for scalable energy storage. Potassium-sulfur (K-S) batteries are recognised as a promising energy storage technology for large-scale applications, due to their high theoretical capacity, low toxicity and the low cost of both potassium and sulfur. However, their grid-scale development is plagued by safety hazards and fast capacity fade. This project aims to address these challenges by developing atomic-level engineering of host materials for sulfur, ....Developing advanced potassium-sulfur batteries for scalable energy storage. Potassium-sulfur (K-S) batteries are recognised as a promising energy storage technology for large-scale applications, due to their high theoretical capacity, low toxicity and the low cost of both potassium and sulfur. However, their grid-scale development is plagued by safety hazards and fast capacity fade. This project aims to address these challenges by developing atomic-level engineering of host materials for sulfur, K metal anode and solid electrolyte. The outcomes of this project will provide increased understanding of the mechanism for K-S batteries and novel strategies for their development, placing Australia at the forefront of K-S batteries for scalable battery research and supporting our cutting-edge energy storage technology.
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Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this ....Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this project include a new fundamental understanding of the effect of mechanical properties on cell function, novel insights into the regulation of stem cell fate, and the development of a new class of roughness-tunable materials suitable for use in tissue engineering and pharmaceutical applications. Read moreRead less
Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
Two-dimensional nanomaterials for wearable zinc ion battery . The project aims to develop a new wearable battery system, based on advanced two-dimensional (2D) nanomaterials with robust energy storage performance and lifespan, for industrial application across the rapidly emerging industries of health monitoring, movement tracking, and smart clothing. The project addresses the critical challenges of control functionalization of advanced 2D nanomaterials for developing wearable energy storage. Th ....Two-dimensional nanomaterials for wearable zinc ion battery . The project aims to develop a new wearable battery system, based on advanced two-dimensional (2D) nanomaterials with robust energy storage performance and lifespan, for industrial application across the rapidly emerging industries of health monitoring, movement tracking, and smart clothing. The project addresses the critical challenges of control functionalization of advanced 2D nanomaterials for developing wearable energy storage. The research outcomes are expected to result in a scalable approach, a variety of advanced 2D nanomaterials, and wearable new battery system, which will bring significant economic and environmental, social, and cultural benefits to Australia and the world.Read moreRead less
Solar-driven thermochemical dissociation of carbon dioxide and water to produce carbon-neutral fuels. The biggest challenge to humanity of the century is to develop enabling clean energy resources to encounter rapidly diminished fossil fuel and accelerated global warming conditions. This project will offer a solution by developing a unique solar-driven thermochemical system capable of cleaving carbon dioxide and water to produce artificial syngas.