Development of a test bed for molecular memory and molecular photovoltaic devices. The development of nanostructured materials and the devices that utilize them is at the forefront of modern science and technology. Electrical devices whose functional units are structurally ordered single molecules dominate biochemical processes, especially pertinent ones being photosynthesis and cellular energy production; artificial devices promise new technologies in multi-$B markets such as long-term data st ....Development of a test bed for molecular memory and molecular photovoltaic devices. The development of nanostructured materials and the devices that utilize them is at the forefront of modern science and technology. Electrical devices whose functional units are structurally ordered single molecules dominate biochemical processes, especially pertinent ones being photosynthesis and cellular energy production; artificial devices promise new technologies in multi-$B markets such as long-term data storage and renewable solar-energy production. Interfacing molecules with macroscopic interconnects poses a great technological challenge, however, and in this project the underlying basic science will be determined through the formation of molecules into device-accessible functional materials.Read moreRead less
Unsteady-State Operation of Slurry and Fixed-Bed Fischer-Tropsch Reactors for Improved Process Performance. The development of efficient gas-to-liquid processes via the Fischer-Tropsch reaction is the most economically viable route for the production of non-petroleum based chemicals and environmentally-friendly fuels from abundant natural gas. This investigation proposes the exploitation of both reactor and catalyst dynamics behaviour to obtain higher hydrocarbon synthesis rate and selectivity n ....Unsteady-State Operation of Slurry and Fixed-Bed Fischer-Tropsch Reactors for Improved Process Performance. The development of efficient gas-to-liquid processes via the Fischer-Tropsch reaction is the most economically viable route for the production of non-petroleum based chemicals and environmentally-friendly fuels from abundant natural gas. This investigation proposes the exploitation of both reactor and catalyst dynamics behaviour to obtain higher hydrocarbon synthesis rate and selectivity not attainable under conventional steady-state operation. With current market conditions of about US$30/bbl for crude oil, even modest process improvements of 30-60% will make the process competitive. Whilst individual national energy policy goals are promoted, the research will further strengthen closer economic and technology ties between France and Australia.Read moreRead less
Biomolecular chemical survival strategies of terrestrial extremophiles and the spectroscopic search for life on Mars. This project is aimed to place Australian research at the forefront of developments in the search for extraterrestrial life, the evolution of life on earth, and the design of new probes for the identification of microorganisms. The research will link key centres in Australia and the UK with international space agencies (NASA and the European Space Agency) in the search for cutti ....Biomolecular chemical survival strategies of terrestrial extremophiles and the spectroscopic search for life on Mars. This project is aimed to place Australian research at the forefront of developments in the search for extraterrestrial life, the evolution of life on earth, and the design of new probes for the identification of microorganisms. The research will link key centres in Australia and the UK with international space agencies (NASA and the European Space Agency) in the search for cutting edge techniques to be used in the search for extraterrestrial life forms and their links to paleo and extremophile life forms on Earth. Read moreRead less
Structure of Adsorbed Surfactant Layers at Ionic Liquid-Air Interfaces. The research conducted in the project will greatly enhance our understanding of the physical properties of ionic liquids, an important new class of designer solvents. Australian researchers will receive advanced training and experience using Sum Frequency Spectroscopy in the laboratory of OI Rutland, and in the use of Neutron Reflection. This project is especially timely with the imminent start-up of the new Australian resea ....Structure of Adsorbed Surfactant Layers at Ionic Liquid-Air Interfaces. The research conducted in the project will greatly enhance our understanding of the physical properties of ionic liquids, an important new class of designer solvents. Australian researchers will receive advanced training and experience using Sum Frequency Spectroscopy in the laboratory of OI Rutland, and in the use of Neutron Reflection. This project is especially timely with the imminent start-up of the new Australian research reactor, OPAL, and will help to seed an active program by Australian researchers at this facility.Read moreRead less
Establishing the relationship between water characteristics and fouling of membranes used in water reuse. The project will result in the following significant benefits to the Australian and international partners: a state-of-the-art laboratory and semi-pilot system from which a full-scale system could be developed and tested, funded by the water industry; an outstanding research project for postgraduate students at the University of Technology, Sydney (UTS), Gwangji Institute of Science and Tech ....Establishing the relationship between water characteristics and fouling of membranes used in water reuse. The project will result in the following significant benefits to the Australian and international partners: a state-of-the-art laboratory and semi-pilot system from which a full-scale system could be developed and tested, funded by the water industry; an outstanding research project for postgraduate students at the University of Technology, Sydney (UTS), Gwangji Institute of Science and Technology, Korea (GIST) and Yale University; and fostering a culture of innovation in the wastewater industry in Australia, Korea and USA and contributing to the commercialization of research by UTS, GIST and YU.Read moreRead less
New Synthetic Routes to the Immobilisation of Mixed Valence Transition Metal Complexes on Conducting Metal Oxides. Highly coloured, electrochemically active transition metal dyes may find application electrochromic devices, where they may switch between contrasting coloured forms through a simple redox reaction. A prerequisite is that the dye be immobilised onto a solid conducting support whilst preserving the electrochemical and optical properties of the dye found in solution. This project tack ....New Synthetic Routes to the Immobilisation of Mixed Valence Transition Metal Complexes on Conducting Metal Oxides. Highly coloured, electrochemically active transition metal dyes may find application electrochromic devices, where they may switch between contrasting coloured forms through a simple redox reaction. A prerequisite is that the dye be immobilised onto a solid conducting support whilst preserving the electrochemical and optical properties of the dye found in solution. This project tackles this problem through a combination of organic and inorganic synthesis to develop new electrochromic dyes that may be attached to mesoporous titania.Read moreRead less
Optical fibre photoreactor for removing airborne molecular contaminants and volatile organic carbons for semiconductor fabrication and fuel cell applications. The collaboration integrates concepts from photocatalysis, optical fibre technology and filtration, to solve important issues in the semiconductor fabrication and fuel cell industries. The project will place Australia amongst the world-leaders in novel integrated photocatalytic/filtration techniques and provide significant opportunities fo ....Optical fibre photoreactor for removing airborne molecular contaminants and volatile organic carbons for semiconductor fabrication and fuel cell applications. The collaboration integrates concepts from photocatalysis, optical fibre technology and filtration, to solve important issues in the semiconductor fabrication and fuel cell industries. The project will place Australia amongst the world-leaders in novel integrated photocatalytic/filtration techniques and provide significant opportunities for penetration, in particular, into the US filtration market. The collaboration will afford young Australian-based researchers the opportunity to access technology, expertise and knowledge developed in the US, which is currently unavailable in Australia. It will strengthen ties between UNSW and UMN and provide opportunities for further collaboration.Read moreRead less
Development of an integrated methodology to assess dewatering system performance in solid-liquid separation. 3D visualisations of microstructures are possible with techniques such as confocal laser microscopy and high resolution X-ray microtomography. Data obtained in-situ enable direct computation of solids assembly properties and their permeability to fluids. A specific application involving aggregate formation and sediment networks could be evaluated through micro-scale analysis combined with ....Development of an integrated methodology to assess dewatering system performance in solid-liquid separation. 3D visualisations of microstructures are possible with techniques such as confocal laser microscopy and high resolution X-ray microtomography. Data obtained in-situ enable direct computation of solids assembly properties and their permeability to fluids. A specific application involving aggregate formation and sediment networks could be evaluated through micro-scale analysis combined with robust fluid flow simulations. The method can potentially be utilized to predict trends such as filtration behaviour of materials under different states of compression. This offers significant benefits in formulating the design of flocculated systems pertinent to a number of industrial sectors wishing to design optimum solid-liquid separation processes.Read moreRead less
Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy ....Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy (the pyridine-2-carboxaldehyde isonicotinoyl hydrazone [PCIH] analogues) which show oral activity. These chelators undergo some interesting iron catalysed oxidation chemistry and it is vital that the mechanism of this reaction be elucidated to determine whether it will be of biological significance upon administration of these compounds as iron chelators.Read moreRead less
A rational approach to a high-resolution structure of the multidrug transporter EmrE. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. Multidrug transporters are membrane proteins responsible for antibiotic resistance in humans. A high-resolution structure of a multidrug resistance protein, together with comprehensive biochemical characterization, w ....A rational approach to a high-resolution structure of the multidrug transporter EmrE. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. Multidrug transporters are membrane proteins responsible for antibiotic resistance in humans. A high-resolution structure of a multidrug resistance protein, together with comprehensive biochemical characterization, would enable a detailed understanding of how these protein functions. Potentially it could also aid in the development of specific inhibitors that would prevent EmrE (and perhaps other similar proteins) from carry out its harmful mission. Read moreRead less