Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Tailoring physiologically-based nanomaterial fertilisers for the biofortification of zinc in broadacre crops. Soil zinc deficiency is a global issue causing low crop yield and malnutrition. This project will develop a new class of fertiliser formulations by combining advanced chemistry techniques with plant physiology knowledge and nanomaterial manufacturing. These products will be designed for enhanced agronomic efficiency and environmental safety.
Next generation hybrid nanomaterials: bispecific antibody-targeted polymers. This project aims to develop and optimise a novel platform technology that will assist in the development of hybrid materials consisting of nanomaterials and biomolecules, which form the basis of many commercial diagnostic devices. A novel antibody, MIL38, will provide the test bed for the technology, which will aim to deliver a platform that is stable under physiological conditions and that enables facile conjugation o ....Next generation hybrid nanomaterials: bispecific antibody-targeted polymers. This project aims to develop and optimise a novel platform technology that will assist in the development of hybrid materials consisting of nanomaterials and biomolecules, which form the basis of many commercial diagnostic devices. A novel antibody, MIL38, will provide the test bed for the technology, which will aim to deliver a platform that is stable under physiological conditions and that enables facile conjugation of nanomaterials with antibodies. This project has the potential to rapidly improve the ligation process between synthetic nanomaterials and biologics, leading to more efficient synthesis of targeted diagnostics. This would provide a significant commercial advantage for any nanomaterials developed for the field, and specifically for this project, expedite translation of MIL38.Read moreRead less
Hydrogen fuel cells with non-precious metal cathode catalysts. Low-cost and robust fuel cell technology is a cornerstone towards the success of the hydrogen economy. The project aims to address the cost and durability of hydrogen fuel cells by advancing low-cost electrocatalysts for oxygen reduction reactions. Novel non-precious catalysts will be developed, and their stability understood in fuel cells using a new approach with in situ current mapping and X-ray computed tomography. The expected ....Hydrogen fuel cells with non-precious metal cathode catalysts. Low-cost and robust fuel cell technology is a cornerstone towards the success of the hydrogen economy. The project aims to address the cost and durability of hydrogen fuel cells by advancing low-cost electrocatalysts for oxygen reduction reactions. Novel non-precious catalysts will be developed, and their stability understood in fuel cells using a new approach with in situ current mapping and X-ray computed tomography. The expected outcomes of this project include material development, improved characterisation techniques and new knowledge on electrocatalysis. The project will benefit Kohodo Hydrogen Energy by positioning them as an Australian leader in low-cost catalysts, and to Australian industries in developing the hydrogen economy. Read moreRead less
Designer Nanoparticles Enable mRNA Protein Factories. Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestio ....Designer Nanoparticles Enable mRNA Protein Factories. Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestion and thermal stress. This will be achieved by tailoring the nanochemistry at multi-scales. Expected outcomes include new knowledge in custom-design of functional nanomaterials for mRNA delivery, and new technology that will bring commercial benefits to the partner organisation and the biopharma sector.Read moreRead less
Reinforcement of rubber products using nanostructured carbon materials. Reinforcement of rubber products using nanostructured carbon materials. This project aims to use the surface-functionalized nanostructured carbons as fillers to reinforce natural rubber. These fillers should significantly enhance the cross-linking between carbon and rubber matrix, leading to high-performance composite products with long lifetime, high thermal conductivity, high oil resistance and outstanding dynamic behaviou ....Reinforcement of rubber products using nanostructured carbon materials. Reinforcement of rubber products using nanostructured carbon materials. This project aims to use the surface-functionalized nanostructured carbons as fillers to reinforce natural rubber. These fillers should significantly enhance the cross-linking between carbon and rubber matrix, leading to high-performance composite products with long lifetime, high thermal conductivity, high oil resistance and outstanding dynamic behaviours. This project is expected to make Australia capable of fabricating superior rubber-based materials and devices that are comfortable, quiet and energy efficient, for use in aircrafts, automobiles and vessels. It should also reduce the use of non-degradable rubber materials, promoting Australia’s economic development and environment protection.Read moreRead less
Lab-on-a-chip mass spectrometry tools for testing illicit drugs. This project aims to develop fit-for-purpose mass spectrometry tools for roadside and workplace testing of illicit drugs. The technology will be based on nanostructured semiconductor chips that are surface-functionalised to enable molecular capture without extensive sample processing and subsequent detection by a novel combination of techniques. The technology is expected to be applicable to saliva, sweat and urine samples.
Advanced protective coatings for thermal energy management devices. This project aims to develop new nanomaterial coatings and advanced plasma coating technology to address the global issue of e-waste caused by short lifespan thermal energy management devices (TEMDs) used in energy (solar, wind, oil), transport (aerospace, automotive, marine) and industrial (manufacturing, mining) sectors. The project expects to overcome issues of erosion and corrosion of TEMDs and toxic coating methods by devel ....Advanced protective coatings for thermal energy management devices. This project aims to develop new nanomaterial coatings and advanced plasma coating technology to address the global issue of e-waste caused by short lifespan thermal energy management devices (TEMDs) used in energy (solar, wind, oil), transport (aerospace, automotive, marine) and industrial (manufacturing, mining) sectors. The project expects to overcome issues of erosion and corrosion of TEMDs and toxic coating methods by developing new nanomaterial coatings and innovative plasma coating technology. This should provide significant benefits such as improved sustainability of TEMDs with improved corrosion resistance and durability, as well as new manufacturing products and processes that have far reaching economic benefits for Australia.Read moreRead less
Printable technologies for high security documents and consumer products. Printable technologies for high security documents and consumer products. This project aims to develop two next-generation printable security feature technologies to protect users from counterfeiting, which costs the world economy billions in lost revenue and undermines the security of citizens. First, it aims to enhance the security of banknotes by developing printable active device patches with energy harvesting flexible ....Printable technologies for high security documents and consumer products. Printable technologies for high security documents and consumer products. This project aims to develop two next-generation printable security feature technologies to protect users from counterfeiting, which costs the world economy billions in lost revenue and undermines the security of citizens. First, it aims to enhance the security of banknotes by developing printable active device patches with energy harvesting flexible polymers as a power source and thin film graphene/polymer nanomaterial as an electrode/energy storage media. Second, it aims to design invisible carbon nanotube inks for optical authentication via near infrared activation. Both technologies are expected to thwart sophisticated counterfeits, particularly those supported by organised crime.Read moreRead less
Novel Nano-Pesticides for Animal Healthcare. This project aims to develop a new nano-pesticide with improved safety and performance. Ticks and buffalo fly cause over $400 million each year in economic losses to the Australian livestock industry and are currently treated with highly toxic synthetic pesticides. Spinosad, a naturally derived pesticide with low environmental impact and low toxicity, will be loaded into silica hollow spheres which will improve adhesion to skin or hair and protect aga ....Novel Nano-Pesticides for Animal Healthcare. This project aims to develop a new nano-pesticide with improved safety and performance. Ticks and buffalo fly cause over $400 million each year in economic losses to the Australian livestock industry and are currently treated with highly toxic synthetic pesticides. Spinosad, a naturally derived pesticide with low environmental impact and low toxicity, will be loaded into silica hollow spheres which will improve adhesion to skin or hair and protect against ultraviolet degradation. The nano-spinosad pesticide is expected to have enhanced efficacy and effective duration in field conditions compared to conventional pesticides, significantly reducing the cost of pest control.Read moreRead less