Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this ....Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this project include a new fundamental understanding of the effect of mechanical properties on cell function, novel insights into the regulation of stem cell fate, and the development of a new class of roughness-tunable materials suitable for use in tissue engineering and pharmaceutical applications. Read moreRead less
Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in c ....Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in cellular pathways. Expected outcomes include a universal technology platform to detect single molecules in single cells, with potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.Read moreRead less
Towards Robust Hydrogen Electrode for High-Rate Alkaline Electrolysis. This project aims to develop robust, efficient porous hybrid hydrogen electrodes for electrochemical hydrogen production in anion exchange membrane water electrolyser. anion exchange membrane water electrolyser powered by renewable energy has emerged as a key avenue towards clean hydrogen with zero carbon footprint. However, the electrochemical turnover on the hydrogen electrode has been significantly hindered by the sluggish ....Towards Robust Hydrogen Electrode for High-Rate Alkaline Electrolysis. This project aims to develop robust, efficient porous hybrid hydrogen electrodes for electrochemical hydrogen production in anion exchange membrane water electrolyser. anion exchange membrane water electrolyser powered by renewable energy has emerged as a key avenue towards clean hydrogen with zero carbon footprint. However, the electrochemical turnover on the hydrogen electrode has been significantly hindered by the sluggish reaction kinetics in alkaline solution. The project is expected to generate cost-effective hydrogen electrodes for hydrogen electrolyzers, advanced knowledge in the electrode material engineering, electrochemical reaction mechanistic insights, and eventually promoted development of disruptive electrolysis technology.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100040
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this ....ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this Hub include advanced manufacturing capacity for connected sensors, strategic partnerships and commercialisation skills to translate sensors research to create economic benefits such as jobs and locally-made products for domestic and export markets, as well as improving the health of Australians.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100036
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
A customised triple-beam microscope for precise fabricating/characterising . This project aims to establish a customised triple-beam microscope to enable precise fabrication and polishing (using ion beams) and characterisation (using electron beam) of a wide range of advanced materials. It will provide solutions to prepare ultra-high quality and artefact-free specimens for transmission electron microscopy studies, and allow fabrication of unique nanostructures and nanostructured templates for hi ....A customised triple-beam microscope for precise fabricating/characterising . This project aims to establish a customised triple-beam microscope to enable precise fabrication and polishing (using ion beams) and characterisation (using electron beam) of a wide range of advanced materials. It will provide solutions to prepare ultra-high quality and artefact-free specimens for transmission electron microscopy studies, and allow fabrication of unique nanostructures and nanostructured templates for high-performance applications. The customised features of the proposed instrument are the first of its kind in Australia. The new knowledge developed through this project will significantly impact on scientific insights and practical applications of new materials related to physics, chemistry, biology, geology and engineering.Read moreRead less
Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The l ....Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.Read moreRead less
Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cos ....Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101637
Funder
Australian Research Council
Funding Amount
$431,318.00
Summary
Heterogeneous Molecular Catalysts for Carbon Dioxide Conversion. This project aims to develop a series of structure-tailored, activity-enhanced and selectivity-oriented heterogeneous molecular catalysts for efficiently converting carbon dioxide (CO2) into value-added fuels and chemicals. Innovations are expected in the rational design and engineering of materials, new mechanistic findings from computation and in-situ characterisation, and breakthroughs in CO2 conversion. Expected outcomes includ ....Heterogeneous Molecular Catalysts for Carbon Dioxide Conversion. This project aims to develop a series of structure-tailored, activity-enhanced and selectivity-oriented heterogeneous molecular catalysts for efficiently converting carbon dioxide (CO2) into value-added fuels and chemicals. Innovations are expected in the rational design and engineering of materials, new mechanistic findings from computation and in-situ characterisation, and breakthroughs in CO2 conversion. Expected outcomes include new synthesis methods, innovative multi-structural engineering strategies, thorough reaction mechanism understanding, and high-performance commercially-relevant CO2 reduction electrolysis. Benefits include a sustainable future for Australia with decreased CO2 emissions and increased green-fuel production.Read moreRead less
Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly t ....Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly technology, new knowledge of cell-nanomaterial interactions and new design principles for nanoparticles with potential future applications in drug delivery, immunology and nanomedicine. This project should provide significant benefits to polymer, nanomaterial and pharmaceutical research and industry in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100259
Funder
Australian Research Council
Funding Amount
$445,437.00
Summary
Next Generation Mass Spectrometry for Single-Cell Metabolomics. Characterising metabolites at the single cell level will provide valuable insights into the functionality of individual cells and reveal mechanisms that cannot be observed in bulk cell analysis. To address existing challenges in single-cell metabolite analysis, this project aims to develop an ultra-sensitive nanostructure-initiator mass spectrometry (NIMS) platform, which uses an innovative carbon material with a carefully designed ....Next Generation Mass Spectrometry for Single-Cell Metabolomics. Characterising metabolites at the single cell level will provide valuable insights into the functionality of individual cells and reveal mechanisms that cannot be observed in bulk cell analysis. To address existing challenges in single-cell metabolite analysis, this project aims to develop an ultra-sensitive nanostructure-initiator mass spectrometry (NIMS) platform, which uses an innovative carbon material with a carefully designed nanostructure to enhance detection efficiency. Expected outcomes include the development of a revolutionary carbon assisted NIMS platform for single-cell metabolomics analysis, and valuable intellectual property of commercial interest to provide economic benefit to Australia through technology advancement.Read moreRead less