Ferrihydrite : Fundamentals of a Natural Nanomaterial. The overarching goal of this project is to obtain the depth of knowledge necessary to achieve specific size, composition and morphology control in the crystallization of nanometer-sized iron oxides. The project focusses on the structural characteristics of the oxy-hydroxide phase ferrihydrite, which is a key intermediate in the formation of other iron oxides. The project will employ characterization techniques such as small-angle scattering ....Ferrihydrite : Fundamentals of a Natural Nanomaterial. The overarching goal of this project is to obtain the depth of knowledge necessary to achieve specific size, composition and morphology control in the crystallization of nanometer-sized iron oxides. The project focusses on the structural characteristics of the oxy-hydroxide phase ferrihydrite, which is a key intermediate in the formation of other iron oxides. The project will employ characterization techniques such as small-angle scattering, high resolution TEM, electron nanodiffraction and magnetic energy barrier distribution measurements to study crystallization processes of the iron oxy-hydroxide ferrihydrite, both in vivo and in vitro. The knowledge gained from the biological realm will allow us to devise new laboratory techniques for the preparation of nanoparticles, and provide important information about iron biomineralization to advance the treatment of iron overload diseases.Read moreRead less
Utilisation of dense gas technology for the development of controlled release active pharmaceutical ingredients (API) delivery systems. The aim of this project is to develop an orally administered drug formulation for the treatment of irritable bowel syndrome and other diseases of the colon. Irritable bowel syndrome is a debilitating condition and the cost to society is similar to that of asthma. As such, the project has the potential to have a major impact on society.
Using magnetic nanotechnology to aid recovery from neurotrauma. Nanotechnology is an exciting new field that holds great promise to solve challenging health issues including neurotrauma associated with brain and spinal cord injury. Current methods to deliver drugs and stimulate tissue repair after neurotrauma do not work effectively and new approaches are urgently need. The recently established research team brings together expertise in nanotechnology and neuroscience to develop new, safe ways t ....Using magnetic nanotechnology to aid recovery from neurotrauma. Nanotechnology is an exciting new field that holds great promise to solve challenging health issues including neurotrauma associated with brain and spinal cord injury. Current methods to deliver drugs and stimulate tissue repair after neurotrauma do not work effectively and new approaches are urgently need. The recently established research team brings together expertise in nanotechnology and neuroscience to develop new, safe ways to deliver drugs and stimulate tissue repair after neurotrauma, and provide quality research training. Specifically designed nanomaterials will deliver drugs slowly over time and act as scaffolds to stop cells dying and stimulate them to restore broken connections and work again. Read moreRead less
Targeted enzymatic treatment of the injured central nervous system using innovative nanotechnology. Nanotechnology and other frontier areas in science have exciting potential to solve major challenges of the 21st century, including health. The proposed research provides the real possibility of discovering ways to alleviate the many complex problems associated with neurotrauma following, for example, brain and spinal cord injury. Current delivery of therapeutics do not work effectively and new ap ....Targeted enzymatic treatment of the injured central nervous system using innovative nanotechnology. Nanotechnology and other frontier areas in science have exciting potential to solve major challenges of the 21st century, including health. The proposed research provides the real possibility of discovering ways to alleviate the many complex problems associated with neurotrauma following, for example, brain and spinal cord injury. Current delivery of therapeutics do not work effectively and new approaches are urgently needed. The recently established powerful multidisciplinary research team combines expertise in nanotechnology, glycobiology and neuroscience to develop novel, safe ways to deliver therapeutic enzymes over biological time-courses. We aim to make broken connections work again, while providing quality research training.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100148
Funder
Australian Research Council
Funding Amount
$150,916.00
Summary
An STM/AFM Facility for Electroactive Materials Characterisation. A Scanning Tunnelling Microscope (STM)/Atomic Force Microscope (AFM) facility for electroactive materials characterisation: This project is expected to address an identified need for the characterisation of electroactive structures using scanning probe microscopy and builds on local expertise in allied methods. The instrumentation includes an electrochemical STM for electrical testing of molecular wires, switches, transistors and ....An STM/AFM Facility for Electroactive Materials Characterisation. A Scanning Tunnelling Microscope (STM)/Atomic Force Microscope (AFM) facility for electroactive materials characterisation: This project is expected to address an identified need for the characterisation of electroactive structures using scanning probe microscopy and builds on local expertise in allied methods. The instrumentation includes an electrochemical STM for electrical testing of molecular wires, switches, transistors and other single molecule electronic components, together with a pico-force tunnelling AFM (PF-TUNA) for the measurement and correlation of nano mechanical and electrical properties of fragile structures over larger areas. The facility will be a core asset for researchers that use electroactive material on conducting substrates in fields including fundamental corrosion science, nanotechnology, and moltronics.Read moreRead less
A multimodal approach to unravel the role of surface properties in nanoparticle-cell interactions using models of medical emergencies. The design and development of multimodal nanoparticles seek to expand upon the benefits of nanoparticles by delivering imaging and therapeutic agents to specific organs, enabling detection and treatment of disease in a single procedure. The successful implementation of this technology is dependent on our detailed understanding of the nanoparticle-cell interaction ....A multimodal approach to unravel the role of surface properties in nanoparticle-cell interactions using models of medical emergencies. The design and development of multimodal nanoparticles seek to expand upon the benefits of nanoparticles by delivering imaging and therapeutic agents to specific organs, enabling detection and treatment of disease in a single procedure. The successful implementation of this technology is dependent on our detailed understanding of the nanoparticle-cell interactions. This project will address this very important issue by evaluating a range of surface functionalised nanoparticles in highly significant models of medical emergencies. This project will enable development of advanced therapeutic interventions for cancer, central nervous system injuries, cardiovascular diseases and pregnancy related disorders.Read moreRead less
New platforms for molecular electronics. Molecular electronics involves the integration of molecules with solid-state electronics and is seen as an answer to the growing need for ultradense and ultrafast computation. This project will design molecular-based components specifically intended for solid-state applications, such as molecular-based memory.
Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to a ....Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.Read moreRead less
From the Electronics of Molecules to Molecular Electronics. Decades of societal progress have been achieved through advances in semiconductor technology during what might be termed the Silicon Revolution. The International Technology Roadmap for Semiconductors has identified molecular components as a solution to problems including data storage and very high-density circuits over the next 15 - 20 years. This project will target some of the difficult challenges in realising molecular electronics t ....From the Electronics of Molecules to Molecular Electronics. Decades of societal progress have been achieved through advances in semiconductor technology during what might be termed the Silicon Revolution. The International Technology Roadmap for Semiconductors has identified molecular components as a solution to problems including data storage and very high-density circuits over the next 15 - 20 years. This project will target some of the difficult challenges in realising molecular electronics technology: molecular contacts to surfaces; function beyond the wire; transistor-like response. This project brings together an international team with expertise in chemical synthesis, electronic structure determination and single molecule conductance measurements to address these challenges. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100087
Funder
Australian Research Council
Funding Amount
$1,100,000.00
Summary
Plasma-focused ion beam for nanoscale characterisation of materials. This project aims to enable research programmes in functional materials to characterise materials using xenon-plasma focused ion beam (FIB) instrumentation. The plasma FIB, with its fast milling speeds across large areas, will enable new three-dimensional imaging experiments and types of transmission electron microscopy samples. This will have applications in engineering, photovoltaics and environmental geosciences, which all n ....Plasma-focused ion beam for nanoscale characterisation of materials. This project aims to enable research programmes in functional materials to characterise materials using xenon-plasma focused ion beam (FIB) instrumentation. The plasma FIB, with its fast milling speeds across large areas, will enable new three-dimensional imaging experiments and types of transmission electron microscopy samples. This will have applications in engineering, photovoltaics and environmental geosciences, which all need to analyse materials on a nanometre scale.Read moreRead less