Organic Linchpin Reagents to Construct Structural Diversity and Complexity. High-energy chemical species such as carbenes, nitrenes or free radicals are often used as reactive intermediates in organic reactions to rapidly generate new bonds, structures and structural complexities. Due to their reactive nature, traditionally only one type of high-energy chemical species can be featured at a time to avoid unwanted complicated side reactions. This project aims to develop novel synthetic substrates ....Organic Linchpin Reagents to Construct Structural Diversity and Complexity. High-energy chemical species such as carbenes, nitrenes or free radicals are often used as reactive intermediates in organic reactions to rapidly generate new bonds, structures and structural complexities. Due to their reactive nature, traditionally only one type of high-energy chemical species can be featured at a time to avoid unwanted complicated side reactions. This project aims to develop novel synthetic substrates bearing multiple carbene and nitrene precursors of different types. These high-energy intermediates can be released in a relayed fashion by controlling orthogonal stimuli and therefore acting as linchpin reagents for quick construction of bio- or photo-active compounds and unprecedented complicated structures.Read moreRead less
A new molecular platform for catalytic synthesis of heterocycles. This project aims to address the lack of efficient methods to prepare cyclic molecules of biological relevance by utilising novel molecular platforms developed in our laboratories. This project expects to generate new cyclic molecules using these innovative molecular platforms by employing catalysts to reduce raw material and energy cost. The expected outcomes of this project include enhanced chemical technology to prepare cyclic ....A new molecular platform for catalytic synthesis of heterocycles. This project aims to address the lack of efficient methods to prepare cyclic molecules of biological relevance by utilising novel molecular platforms developed in our laboratories. This project expects to generate new cyclic molecules using these innovative molecular platforms by employing catalysts to reduce raw material and energy cost. The expected outcomes of this project include enhanced chemical technology to prepare cyclic molecules of pharmaceutical importance and the training of highly skilled PhD students. This should provide significant benefits, such as increased capacity for the development of new pharmaceuticals and advanced materials.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH200100023
Funder
Australian Research Council
Funding Amount
$4,950,000.00
Summary
ARC Research Hub for Innovative Nitrogen Fertilisers and Inhibitors. This Hub aims to transform agriculture by delivering a new class of nitrogen (N) fertilisers and inhibitors designed to stem the 50-80% losses to the environment in current products. It is intended to generate new knowledge and valuable intellectual property in controlled released and coated N fertiliser products using a novel co-design process involving representatives of the whole value chain from product design through to va ....ARC Research Hub for Innovative Nitrogen Fertilisers and Inhibitors. This Hub aims to transform agriculture by delivering a new class of nitrogen (N) fertilisers and inhibitors designed to stem the 50-80% losses to the environment in current products. It is intended to generate new knowledge and valuable intellectual property in controlled released and coated N fertiliser products using a novel co-design process involving representatives of the whole value chain from product design through to validation and adoption. The project estimates possible 20% gains in efficiency of N use, delivering large costs savings, improved productivity, increased profitability and decreased environmental impacts, helping the Australian food and agribusiness sector to reach its 2030 target of $100B value added.Read moreRead less
Designer solvents to control reaction outcome. This project aims to control outcomes of chemical reactions using specifically designed ionic liquids as solvents. Ionic liquids are distinct from molecular solvents and are underused due to the limited understanding of their effects on chemical processes. We are developing a predictive framework to explain such effects and this project aims to exploit this new knowledge, using both new and rarely applied ionic liquids to control reaction outcomes. ....Designer solvents to control reaction outcome. This project aims to control outcomes of chemical reactions using specifically designed ionic liquids as solvents. Ionic liquids are distinct from molecular solvents and are underused due to the limited understanding of their effects on chemical processes. We are developing a predictive framework to explain such effects and this project aims to exploit this new knowledge, using both new and rarely applied ionic liquids to control reaction outcomes. The significance lies in the ability to optimise reaction outcomes without the need for solvent screening. The innovation lies in the measurement of microscopic interactions between solvent and reagents, and the use of these interactions to affect a given process.Read moreRead less
Rational design of new synthetic antifreeze molecules for cryopreservation. This project aims to synthesise new carbohydrate-based surfactants optimised for use as cryoprotectants, and to accurately measure, model and optimise their performance. The project will use state-of-the-art experimental methods and advanced phase-field modelling techniques to optimise the cryoprotectants so that they reduce osmotic stress in cells and inhibit ice crystal growth during freezing and thawing. The expected ....Rational design of new synthetic antifreeze molecules for cryopreservation. This project aims to synthesise new carbohydrate-based surfactants optimised for use as cryoprotectants, and to accurately measure, model and optimise their performance. The project will use state-of-the-art experimental methods and advanced phase-field modelling techniques to optimise the cryoprotectants so that they reduce osmotic stress in cells and inhibit ice crystal growth during freezing and thawing. The expected outcomes will be novel cryoprotectants that are easy to synthesise, non-toxic and effective, opening up new possibilities for the cryopreservation of cells, organs and possibly even whole organisms. This will have broad impact in critical applications such as long-term blood storage, reproductive technology and stem cell therapy, as well as preservation of endangered species.Read moreRead less
Shifting the trend in radical battery research . The project aims to address a growing problem of increasing energy consumption by storing intermittent energy from the sun in affordable and efficient flow batteries. The project expects to generate new knowledge in the areas of materials science and battery research by using innovative theoretical chemistry approaches to studying electrochemical properties of nitroxide radicals in ionic media. The project aims to develop radical organic flow batt ....Shifting the trend in radical battery research . The project aims to address a growing problem of increasing energy consumption by storing intermittent energy from the sun in affordable and efficient flow batteries. The project expects to generate new knowledge in the areas of materials science and battery research by using innovative theoretical chemistry approaches to studying electrochemical properties of nitroxide radicals in ionic media. The project aims to develop radical organic flow batteries by utilising ionic liquids to stabilise radicals. Intended outcomes of the project include improved efficiency of flow batteries that can store energy from widely used solar panels. This should provide significant benefits to Australia’s effort to switch to renewable energy technologies. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100677
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Deconstructing molecular self-assembly by advanced mass spectrometry. This project aims to develop ion-mobility mass spectrometry methods to observe the molecular evolution of model self-assembly reactions with high temporal and structural resolution, and interrogate the intrinsic gas phase functionality of the assemblies themselves, including aggregation, inclusion and disassembly behaviours. Lack of knowledge of reaction intermediates, mechanisms and kinetics hampers the industrial potential o ....Deconstructing molecular self-assembly by advanced mass spectrometry. This project aims to develop ion-mobility mass spectrometry methods to observe the molecular evolution of model self-assembly reactions with high temporal and structural resolution, and interrogate the intrinsic gas phase functionality of the assemblies themselves, including aggregation, inclusion and disassembly behaviours. Lack of knowledge of reaction intermediates, mechanisms and kinetics hampers the industrial potential of self-assembly to fabricate highly functional materials. This project expects to determine the critical link between the assemblies’ structure and function, and provide the rational framework to optimise and direct synthetic outcomes. This could enable Australian manufacturers to create low-energy production processes of high value commodities.Read moreRead less