Organometallic Transformations of Organic Compounds. The program will develop new metal-based catalysts for two main purposes (i) transforming basic hydrocarbons eg. natural gas and low-molecular-weight petroleum products into more advanced compounds (such as alcohols, alkenes and carboxylic acids); and (ii) converting nitrogen gas into nitrogen-containing compounds eg. ammonia or ammonia derivatives. In both projects, the aim is to take readily available and abundant starting materials that ar ....Organometallic Transformations of Organic Compounds. The program will develop new metal-based catalysts for two main purposes (i) transforming basic hydrocarbons eg. natural gas and low-molecular-weight petroleum products into more advanced compounds (such as alcohols, alkenes and carboxylic acids); and (ii) converting nitrogen gas into nitrogen-containing compounds eg. ammonia or ammonia derivatives. In both projects, the aim is to take readily available and abundant starting materials that are currently difficult to utilise and to design and develop specific reagents to convert them to "value-added" products. The program will also explore the mode of action of metal-based reagents leading to better reagent and catalyst design.Read moreRead less
Metallographitic Discs as New Materials. Materials science plays a pivotal role in determining and improving economic performance and quality of life. While application of materials is the ultimate goal, basic understanding of a material's behaviour from the atomic/nano-level to macrostructural level is also of critical importance. This project builds upon the recent success of soluble, well-defined carbon discs in molecular electronics, through the preparation and study of metal-containing deri ....Metallographitic Discs as New Materials. Materials science plays a pivotal role in determining and improving economic performance and quality of life. While application of materials is the ultimate goal, basic understanding of a material's behaviour from the atomic/nano-level to macrostructural level is also of critical importance. This project builds upon the recent success of soluble, well-defined carbon discs in molecular electronics, through the preparation and study of metal-containing derivatives as new advanced crystalline and liquid crystalline materials. The possibility of enhanced electronic, optical and/or magnetic properties, along with good processability, make these materials potential candidates as the active component of future, technologically important devices.Read moreRead less
A new molecular platform for catalytic synthesis of heterocycles. This project aims to address the lack of efficient methods to prepare cyclic molecules of biological relevance by utilising novel molecular platforms developed in our laboratories. This project expects to generate new cyclic molecules using these innovative molecular platforms by employing catalysts to reduce raw material and energy cost. The expected outcomes of this project include enhanced chemical technology to prepare cyclic ....A new molecular platform for catalytic synthesis of heterocycles. This project aims to address the lack of efficient methods to prepare cyclic molecules of biological relevance by utilising novel molecular platforms developed in our laboratories. This project expects to generate new cyclic molecules using these innovative molecular platforms by employing catalysts to reduce raw material and energy cost. The expected outcomes of this project include enhanced chemical technology to prepare cyclic molecules of pharmaceutical importance and the training of highly skilled PhD students. This should provide significant benefits, such as increased capacity for the development of new pharmaceuticals and advanced materials.Read moreRead less
Reactions of Coordinated Dinitrogen. The program will develop novel metal-based catalysts and reagents that will transform nitrogen gas into ammonia and other nitrogen-containing compounds (nitrogen fixation). This fundamental chemical transformation underpins major chemical industries and this new approach using organometallic catalysts will significantly improve the efficiency of ammonia production and reduce the energy and harsh reaction conditions currently required. This program will desi ....Reactions of Coordinated Dinitrogen. The program will develop novel metal-based catalysts and reagents that will transform nitrogen gas into ammonia and other nitrogen-containing compounds (nitrogen fixation). This fundamental chemical transformation underpins major chemical industries and this new approach using organometallic catalysts will significantly improve the efficiency of ammonia production and reduce the energy and harsh reaction conditions currently required. This program will design catalysts with multiple complementary metal centres tailored to bind and activate nitrogen gas to facilitate its reaction with hydrogen or other reagents.Read moreRead less
Charging transition metals with activating alkanes. The project aims to engineer positively charged metal complexes and use them to explore the chemistry of bound activated alkane ligands. The transformation of cheap, plentiful alkanes into more valuable products is a major quest in chemistry, and complexes of alkanes bound to metals are expected to play a key role in transformations of alkanes. The project intends to use the activated metal bound alkane to transform the normally inert alkane in ....Charging transition metals with activating alkanes. The project aims to engineer positively charged metal complexes and use them to explore the chemistry of bound activated alkane ligands. The transformation of cheap, plentiful alkanes into more valuable products is a major quest in chemistry, and complexes of alkanes bound to metals are expected to play a key role in transformations of alkanes. The project intends to use the activated metal bound alkane to transform the normally inert alkane into compounds with desirable functional groups. This should make the synthesis of alkane complexes stable at room temperature in solution a realistic possibility. These cheap, plentiful alkanes can be turned into more valuable products, bringing benefits to industry.Read moreRead less
Synthesis of new heterocyclic analogues of isoflavones. Intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of hormone-dependent cancers such as breast and prostate cancer, and heart disease. The isoflavones resemble endogenous estradiol in structure, and have been shown to display weak estrogenic activity. Novogen Limited is pioneering the development of novel drug candidates based on isoflavones. This collaborative research project deals with the development o ....Synthesis of new heterocyclic analogues of isoflavones. Intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of hormone-dependent cancers such as breast and prostate cancer, and heart disease. The isoflavones resemble endogenous estradiol in structure, and have been shown to display weak estrogenic activity. Novogen Limited is pioneering the development of novel drug candidates based on isoflavones. This collaborative research project deals with the development of synthetic methodologies for the preparation of new analogues of isoflavone metabolites as potential drug candidates. The target compounds will be evaluated for possible therapeutic use by the industry partner.Read moreRead less
Synthesis of pyrroloquinoline analogues of isoflavone metabolites. Cancer and heart disease are the two main diseases that affect our society indiscriminately and put enormous drains on healthcare resources. The intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of cancers and heart disease. Novogen Limited is pioneering the development of novel drug candidates based on phytoestrogen metabolites. This collaborative research project deals with the development ....Synthesis of pyrroloquinoline analogues of isoflavone metabolites. Cancer and heart disease are the two main diseases that affect our society indiscriminately and put enormous drains on healthcare resources. The intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of cancers and heart disease. Novogen Limited is pioneering the development of novel drug candidates based on phytoestrogen metabolites. This collaborative research project deals with the development of synthetic methodologies for the preparation of new analogues of phytoestrogen metabolites as potential drug candidates. The target compounds will be evaluated for possible therapeutic use by the industry partner.Read moreRead less
Organometallic Transformations of Organic Molecules. Simple hydrocarbons such as natural gas and petroleum are amongst the most abundant and readily available natural feedstocks for the organic chemical industry. However, apart from simply burning them for fuel, there are very few methods for using these materials as starting materials for industry. In chemical terms, simple hydrocarbons are very stable and this makes them difficult substances to convert cleanly to other more useful compounds. ....Organometallic Transformations of Organic Molecules. Simple hydrocarbons such as natural gas and petroleum are amongst the most abundant and readily available natural feedstocks for the organic chemical industry. However, apart from simply burning them for fuel, there are very few methods for using these materials as starting materials for industry. In chemical terms, simple hydrocarbons are very stable and this makes them difficult substances to convert cleanly to other more useful compounds. This research program investigates new approaches for converting hydrocarbons to more useful materials by using metals such as iron and ruthenium. This research program will provide a new route to ?value-added? products from hydrocarbons and develop new uses for these abundant raw materials.Read moreRead less
From Nanostructured Functional Materials to Sustainable Processes. Nano-structured functional materials in the areas of catalysis and reversible hydrogen storage will be developed with the view to arrive at (a) sustainable processes and (b) the adoption of hydrogen as an energy carrier. These aims are driven by a global need to change the industrial paradigm due to environmental pressures and limited resources, particularly in terms of energy. Expected outcomes are new avenues to process intens ....From Nanostructured Functional Materials to Sustainable Processes. Nano-structured functional materials in the areas of catalysis and reversible hydrogen storage will be developed with the view to arrive at (a) sustainable processes and (b) the adoption of hydrogen as an energy carrier. These aims are driven by a global need to change the industrial paradigm due to environmental pressures and limited resources, particularly in terms of energy. Expected outcomes are new avenues to process intensification, leading to novel commercial routes, and a hydrogen storage technology which has the potential to play a strong part in the global economy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100170
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A tuneable femtosecond light source for materials and biological sciences. Researchers at The Australian National University, Monash University and The University of Technology, Sydney are involved in a range of projects where new molecules are synthesised or discovered in nature. Molecules like these have applications in new photonics or energy technologies. This integrated facility will afford intense light of varying pulse durations to investigate the behaviour and performance of such molecul ....A tuneable femtosecond light source for materials and biological sciences. Researchers at The Australian National University, Monash University and The University of Technology, Sydney are involved in a range of projects where new molecules are synthesised or discovered in nature. Molecules like these have applications in new photonics or energy technologies. This integrated facility will afford intense light of varying pulse durations to investigate the behaviour and performance of such molecules.Read moreRead less