The Synthesis and Analysis of Certain Explosives and Illicit Drugs for Improved Forensic Detection. There is an increasing demand within law enforcement agencies, worldwide, for selective and sensitive methods for the determination of illicit substances. Over the last decade Deakin University chemists have played a major role in establishing the utility of chemiluminescent reactions for the determination of a variety of pharmaceutical opiates in process streams. This project seeks to build upon ....The Synthesis and Analysis of Certain Explosives and Illicit Drugs for Improved Forensic Detection. There is an increasing demand within law enforcement agencies, worldwide, for selective and sensitive methods for the determination of illicit substances. Over the last decade Deakin University chemists have played a major role in establishing the utility of chemiluminescent reactions for the determination of a variety of pharmaceutical opiates in process streams. This project seeks to build upon these successes, in order to develop innovative analytical strategies for forensic detection of certain illicit drugs and explosives. The results of this research have the potential to revolutionise key aspects of forensic analysis.Read moreRead less
New approaches to the treatment of potable water in the presence of algal blooms. The processing of blue green algae rich waters and subsequent release of algal metabolites causes taste and odour problems and toxins that affect potable water safety. This project will define a preferred approach to the processing of these waters and provide quantitative analysis tools to help water authorities guarantee water quality and safety. The defined process routes and analysis procedures will also resul ....New approaches to the treatment of potable water in the presence of algal blooms. The processing of blue green algae rich waters and subsequent release of algal metabolites causes taste and odour problems and toxins that affect potable water safety. This project will define a preferred approach to the processing of these waters and provide quantitative analysis tools to help water authorities guarantee water quality and safety. The defined process routes and analysis procedures will also result in better water conservation (lower net water losses in processing). This will allow better regulation of water quality, safety and management by water authorities and improve consumer confidence in the potable water supply.Read moreRead less
Doped alumina with tailored material properties for battery applications. This project aims to develop tailored alumina materials for lithium ion battery separators through a novel in-situ approach that will: (1) produce uniform doped alumina for improved safety, (2) target specific surface and bulk material properties to increase the overall performance, and (3) reduce manufacturing costs by integrating the process with new technology developed for the production of high purity alumina. Signifi ....Doped alumina with tailored material properties for battery applications. This project aims to develop tailored alumina materials for lithium ion battery separators through a novel in-situ approach that will: (1) produce uniform doped alumina for improved safety, (2) target specific surface and bulk material properties to increase the overall performance, and (3) reduce manufacturing costs by integrating the process with new technology developed for the production of high purity alumina. Significant advances are proposed for overcoming current manufacturing limitations of doped alumina. Building research capacity and knowledge in battery material manufacturing will benefit a range of industries across Australia, whilst providing new opportunities for growth in local communities.Read moreRead less
Next-generation latent fingermark detection using functional nanomaterials. Next-generation latent fingermark detection using functional nanomaterials. This project aims to develop a nanotechnology-based fingermark detection technique applicable in standard police laboratories and crime scenes. Current methods only detect half the fingermarks on an object, so many criminals are not identified. This project will use silicon oxide nanoparticles with a luminescent dye to target fingermark secretion ....Next-generation latent fingermark detection using functional nanomaterials. Next-generation latent fingermark detection using functional nanomaterials. This project aims to develop a nanotechnology-based fingermark detection technique applicable in standard police laboratories and crime scenes. Current methods only detect half the fingermarks on an object, so many criminals are not identified. This project will use silicon oxide nanoparticles with a luminescent dye to target fingermark secretion components and address interference from substrate chemistries and background luminescence. Moving away from traditional detection methods is expected to improve law enforcement outcomes, as fingermarks that current technologies cannot detect will be visualised for the first time.Read moreRead less
Chemistry of uranium extraction - studies on the dissolution of uranium ores in a complex solution matrix. Olympic Dam is the world's largest uranium deposit. With a planned massive expansion of the mine's operations, it could generate more than $10b per year. The mineral ores found there, however, are highly complex and poorly understood. This project will investigate and determine the detailed characteristics and chemistry of the mineral ore and offer process improvements that will increase th ....Chemistry of uranium extraction - studies on the dissolution of uranium ores in a complex solution matrix. Olympic Dam is the world's largest uranium deposit. With a planned massive expansion of the mine's operations, it could generate more than $10b per year. The mineral ores found there, however, are highly complex and poorly understood. This project will investigate and determine the detailed characteristics and chemistry of the mineral ore and offer process improvements that will increase the productivity and improve the economics of extraction of the ore. This project will also address the serious deficiency of researchers in this field by creating a sustainable skills development program in mineral extraction and separation technology.Read moreRead less
Strategies for the detection of designer steroids in greyhounds. Strategies for the detection of designer steroids in greyhounds. This project aims to develop strategies to detect designer steroids in racing greyhounds to safeguard industry integrity and animal welfare. These strategies include in vivo and comparative in vitro studies of steroid metabolism, mass-spectrometric elucidation of metabolite structures, and synthesis of putative steroid metabolites with different stereochemistries and ....Strategies for the detection of designer steroids in greyhounds. Strategies for the detection of designer steroids in greyhounds. This project aims to develop strategies to detect designer steroids in racing greyhounds to safeguard industry integrity and animal welfare. These strategies include in vivo and comparative in vitro studies of steroid metabolism, mass-spectrometric elucidation of metabolite structures, and synthesis of putative steroid metabolites with different stereochemistries and oxidation patterns as reference materials. This project will use major metabolites identified by these studies to develop analytical procedures to test for drug abuse at greyhound race meetings. The project will target twelve readily available designer steroid supplements that have significant risk of abuse.Read moreRead less
Redox processes in Bayer liquors. Alumina, and the aluminium produced from it, are amongst Australia's most important mineral commodities, earning about $8 billion p.a. in exports. However, ongoing technological improvements are needed for Australian producers to remain globally competitive. This project addresses a key problem in alumina production - the behaviour of organic impurities - which will help to increase industrial productivity and reduce energy consumption. Insights gained from this ....Redox processes in Bayer liquors. Alumina, and the aluminium produced from it, are amongst Australia's most important mineral commodities, earning about $8 billion p.a. in exports. However, ongoing technological improvements are needed for Australian producers to remain globally competitive. This project addresses a key problem in alumina production - the behaviour of organic impurities - which will help to increase industrial productivity and reduce energy consumption. Insights gained from this research will also minimize the environmental and occupational health impacts of various process emissions, making the industry more sustainable.Read moreRead less
Design, Evaluation, and Selection of Novel Pt(IV) Complexes as Anticancer Agents. Platinum anticancer drugs are arguably the most widely used anticancer agents in the world but serious problems remain with toxicity and resistance. Platinum(IV) compounds have numerous advantages in terms of stability and thereby, lower toxicity. In this project we will exploit these advantages along with others that we have discovered recently and our understanding of the chemistry and biology of platinum(IV) to ....Design, Evaluation, and Selection of Novel Pt(IV) Complexes as Anticancer Agents. Platinum anticancer drugs are arguably the most widely used anticancer agents in the world but serious problems remain with toxicity and resistance. Platinum(IV) compounds have numerous advantages in terms of stability and thereby, lower toxicity. In this project we will exploit these advantages along with others that we have discovered recently and our understanding of the chemistry and biology of platinum(IV) to develop novel platinum(IV) compounds to the point where the industry partner can commercialise them.Read moreRead less
Gallium, Copper and Metal Fluoride Complexes Designed for Brain Imaging. This project aims to develop fundamental synthetic coordination chemistry directed toward the development of new agents for imaging brain perfusion using positron emission tomography. The research will focus on developing new coordination complexes containing positron-emitting isotopes of copper, gallium and fluorine. The goal is incorporate in these radionuclides into small molecules that can be used for the molecular imag ....Gallium, Copper and Metal Fluoride Complexes Designed for Brain Imaging. This project aims to develop fundamental synthetic coordination chemistry directed toward the development of new agents for imaging brain perfusion using positron emission tomography. The research will focus on developing new coordination complexes containing positron-emitting isotopes of copper, gallium and fluorine. The goal is incorporate in these radionuclides into small molecules that can be used for the molecular imaging of the brain. This chemistry will have the potential to replace existing technologies that rely on single-photon emission from technetium and the technique of single photon emission computed tomography.Read moreRead less
Electrodeposited Cathodes with Tunable Stoichiometry for Alkaline Batteries. The growing dependency on intermittently-available renewable energy sources has resulted in metal-ion batteries being adopted as the most common solution; yet its fabrication requires multi-stage high-temperature processing leading to high costs, quality issues, and reduced service life. Thus, the present project targets the room-temperature fabrication of binary and ternary oxide cathodes by a single-step, high-yield, ....Electrodeposited Cathodes with Tunable Stoichiometry for Alkaline Batteries. The growing dependency on intermittently-available renewable energy sources has resulted in metal-ion batteries being adopted as the most common solution; yet its fabrication requires multi-stage high-temperature processing leading to high costs, quality issues, and reduced service life. Thus, the present project targets the room-temperature fabrication of binary and ternary oxide cathodes by a single-step, high-yield, cost-effective technique and their integration into Na-ion batteries with minimal and no processing. The expected outcomes from this novel and efficient device fabrication can lead to significant commercial, social, and environmental benefits owing to the advancement of the battery industry and associated job creation.
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