Free radical generation and reactions in ultrasound assisted processes. The project is designed to give a full quantitative physical and chemical account of the free radicals generated from the passage of ultrasound through a liquid. The study will be end-focused to produce advanced materials of potential use as catalysts in fuel cells and other materials that may be used in diagnostic and therapeutic applications.
Investigation and Prediction of the Novel Properties of Dendrimers. Dendrimers are a new class of highly branched polymers, which have, until now, been difficult to characterise by conventional means. This project will develop and apply molecular simulation techniques to reveal the chemical and physical properties of dendrimers and their interactions with other molecules. These novel molecules potentially have beneficial applications to areas such as drug delivery and electronic materials. Th ....Investigation and Prediction of the Novel Properties of Dendrimers. Dendrimers are a new class of highly branched polymers, which have, until now, been difficult to characterise by conventional means. This project will develop and apply molecular simulation techniques to reveal the chemical and physical properties of dendrimers and their interactions with other molecules. These novel molecules potentially have beneficial applications to areas such as drug delivery and electronic materials. The outcome of this work will assist in the exploitation of this beneficial application and will provide the basis for efficient processing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883036
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research. The expected benefits that will arise will include: green chemical processes with improved environmental and economic impacts; improved treatments and diagnoses of diseases; understanding of fundamental geological processes; identification of the earliest forms; studies of archaeological artefacts; evolution of life on Earth; the design of improved dental materials. Ultimatel ....Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research. The expected benefits that will arise will include: green chemical processes with improved environmental and economic impacts; improved treatments and diagnoses of diseases; understanding of fundamental geological processes; identification of the earliest forms; studies of archaeological artefacts; evolution of life on Earth; the design of improved dental materials. Ultimately, this research will include economic and social benefits in; industrial processes; the mining industry; medicine; and dentistry. An understanding of the origin and early evolution of life on Earth also has many social implications.Read moreRead less
Composite nanomaterials for environmental remediation and fuel cell applications. Australia, in response to a mounting global awareness, needs to find cost effective energy storage sources to replace fossil fuels. The program will significantly add to research that provides fundamental advances in energy storage, in the form of fuel cells, and in the remediation of organic pollutants. It will also contribute to the future development of technologies in these areas that will have substantial ben ....Composite nanomaterials for environmental remediation and fuel cell applications. Australia, in response to a mounting global awareness, needs to find cost effective energy storage sources to replace fossil fuels. The program will significantly add to research that provides fundamental advances in energy storage, in the form of fuel cells, and in the remediation of organic pollutants. It will also contribute to the future development of technologies in these areas that will have substantial benefits to the broader community. The program will provide expert training for future chemists and connect them into leading international research groups led by our PIs.Read moreRead less
Metal catalysed reactions in organic synthesis. The major aim of this project is to develop highly efficient metal-catalysed routes to pharmaceuticals, e.g. new antibiotics and other commercially important organic molecules.
Particular attention will be paid to developing systems which facilitate the addition of readily available, cheap small molecules, e.g. hydrogen and carbon monoxide, to unsaturated organic molecules with high regio- and stereoselectivity.
Worldwide demand for enantiomeric ....Metal catalysed reactions in organic synthesis. The major aim of this project is to develop highly efficient metal-catalysed routes to pharmaceuticals, e.g. new antibiotics and other commercially important organic molecules.
Particular attention will be paid to developing systems which facilitate the addition of readily available, cheap small molecules, e.g. hydrogen and carbon monoxide, to unsaturated organic molecules with high regio- and stereoselectivity.
Worldwide demand for enantiomerically pure chiral molecules (i.e. one mirror-image form) continues to rise. New metal-catalysed asymmetric syntheses will help meet this challenge. Tandem metal-catalysed reactions will be used to prepare new heterocyclic compounds with potential as specific metal binding agents and biosensors.Read moreRead less
Biomimetic and Methodology Based Total Synthesis of Bioactive Natural Products. The proposal will study the synthesis of novel natural products that possess biological activities. Most significantly, this project will deliver compounds with anticancer activity. In addition, chemistry may be developed which could be utilised to synthesise a number of bioactive molecules. The rewards of the synthesis of compounds and application for the treatment of cancer and other diseases are enormous for the ....Biomimetic and Methodology Based Total Synthesis of Bioactive Natural Products. The proposal will study the synthesis of novel natural products that possess biological activities. Most significantly, this project will deliver compounds with anticancer activity. In addition, chemistry may be developed which could be utilised to synthesise a number of bioactive molecules. The rewards of the synthesis of compounds and application for the treatment of cancer and other diseases are enormous for the community and in the education and training of scientists.Read moreRead less
Total Synthesis of Novel Metabolites form Microorganisms. The main aim of this proposal is to achieve the chemical synthesis of a number of biologically active novel natural products isolated from microorganisms. This will involve the development of new methods as well as improvement on exisiting approaches developed so far. The targets will include the myxobacteria metabolites crocacins A, B and D and apicularen A, the streptomyces metabolites reveromycin A and spirofungin A and the fungal meta ....Total Synthesis of Novel Metabolites form Microorganisms. The main aim of this proposal is to achieve the chemical synthesis of a number of biologically active novel natural products isolated from microorganisms. This will involve the development of new methods as well as improvement on exisiting approaches developed so far. The targets will include the myxobacteria metabolites crocacins A, B and D and apicularen A, the streptomyces metabolites reveromycin A and spirofungin A and the fungal metabolite zaragozic acid C.
Read moreRead less
Synthesis of Bioactive Metabolites from Myxobacteria. The crocacins and apicularens are two diverse groups of biologically active molecules isolated from myxobacteria. Crocacins A-D are dipeptides which show antifungal activity and are highly cytostatic in mammalian cell cultures. The novel macrolide apicularen A is highly active against a number of human tumour cell lines and shows promise as a new type of anticancer compound. The aim of this project is develop a methodology to synthesise these ....Synthesis of Bioactive Metabolites from Myxobacteria. The crocacins and apicularens are two diverse groups of biologically active molecules isolated from myxobacteria. Crocacins A-D are dipeptides which show antifungal activity and are highly cytostatic in mammalian cell cultures. The novel macrolide apicularen A is highly active against a number of human tumour cell lines and shows promise as a new type of anticancer compound. The aim of this project is develop a methodology to synthesise these novel compounds.Read moreRead less
Material Properties of Nanocrystals. The mechanical characteristics of nanocrystals determine the viability of many novel applications and devices emerging from the field of nanotechnology. Despite their fundamental importance, the mechanical properties of these nanocrystals is only vaguely understood, because their size has prohibited their measurement. In this project, we shall investigate the mechanical properties of these materials for the first time using a combination of theoretical modell ....Material Properties of Nanocrystals. The mechanical characteristics of nanocrystals determine the viability of many novel applications and devices emerging from the field of nanotechnology. Despite their fundamental importance, the mechanical properties of these nanocrystals is only vaguely understood, because their size has prohibited their measurement. In this project, we shall investigate the mechanical properties of these materials for the first time using a combination of theoretical modelling, atomic force microscopy, and a new form of spectroscopy that allows the actual deformation of nanocrystals to be measured. The fundamental scientific knowledge gained is expected to impact on the development of current and future nanodevices.Read moreRead less
Special Research Initiatives - Grant ID: SR0354775
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian Synchrotron Sciences Network. A synchrotron light source is a critical piece of infrastructure for a modern technological nation. In 2001, the Victorian government announced that it would contribute $157M towards the establishment of a national synchrotron facility, becoming operational in 2007. The research performed at such a facility is exceedingly diverse, and often the underpinning technology is the only point of contact for users. A vibrant and productive facility requires a tra ....Australian Synchrotron Sciences Network. A synchrotron light source is a critical piece of infrastructure for a modern technological nation. In 2001, the Victorian government announced that it would contribute $157M towards the establishment of a national synchrotron facility, becoming operational in 2007. The research performed at such a facility is exceedingly diverse, and often the underpinning technology is the only point of contact for users. A vibrant and productive facility requires a transparent interface between the scientist and the technology. This Network will set up the communication channels within the user base, and between the users and the facility development program.Read moreRead less