Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100064
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
A facility for sensitive and precise isotopic dating of the earth's and extraterrestrial rocks. SPIDE2R will be a new generation mass spectrometer for very precise and sensitive dating and forensics applications in earth and planetary sciences, hydrology, climate studies, and nuclear and archaeological fingerprinting. The unprecedented sensitivity of this unique instrument will provide enhanced capabilities for solving long-standing problems requiring precise geological time resolution, as well ....A facility for sensitive and precise isotopic dating of the earth's and extraterrestrial rocks. SPIDE2R will be a new generation mass spectrometer for very precise and sensitive dating and forensics applications in earth and planetary sciences, hydrology, climate studies, and nuclear and archaeological fingerprinting. The unprecedented sensitivity of this unique instrument will provide enhanced capabilities for solving long-standing problems requiring precise geological time resolution, as well as opening new areas of research. It will be the instrument of choice for analysing small, rare samples such as those returned by space missions. The Australian-built high sensitivity source and ion detection systems can be retrofitted onto other mass spectrometers, opening a new area of commercialisation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989127
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
A High-Throughput Neutron Spectrometer for The Study of Atomic and Molecular Motion at ANSTO. Neutron scattering enables new science across a broad range of disciplines, and for this reason it is undergoing major expansion in the USA, Europe, Japan and Australia. Various diffactometers and spectrometers have recently been built at ANSTO, but an instrumental option for a high-throughput cross-discipline spectroscopy is urgently needed. Fortunately, it is fairly straightforward to add this type of ....A High-Throughput Neutron Spectrometer for The Study of Atomic and Molecular Motion at ANSTO. Neutron scattering enables new science across a broad range of disciplines, and for this reason it is undergoing major expansion in the USA, Europe, Japan and Australia. Various diffactometers and spectrometers have recently been built at ANSTO, but an instrumental option for a high-throughput cross-discipline spectroscopy is urgently needed. Fortunately, it is fairly straightforward to add this type of option to an existing spectrometer that will broaden its user-base from specialised applications in physics to more general applications in physics, chemistry, materials-science and biology. This additional option provides a totally new way for Australian scientists to study atomic and molecular motions. Read moreRead less
Probing polynuclear platinum biomolecule interactions. Cancer affects one in four Australians and 50% of cancer patients are treated with cisplatin. BBR3464 is a new type of platinum anticancer drug that has shown promise in clinical trials, including results in cancers that do not respond to cisplatin treatment. Second-generation analogues, now under development, may offer significant advantages. This international collaboration with the inventor of these new drugs puts Australian research at t ....Probing polynuclear platinum biomolecule interactions. Cancer affects one in four Australians and 50% of cancer patients are treated with cisplatin. BBR3464 is a new type of platinum anticancer drug that has shown promise in clinical trials, including results in cancers that do not respond to cisplatin treatment. Second-generation analogues, now under development, may offer significant advantages. This international collaboration with the inventor of these new drugs puts Australian research at the forefront of the clinical development. There is the potential for the generation of new IP from new strategies in the design of improved anticancer drugs. The project builds strong international links and provides international training for Australian PhD students. Read moreRead less
Investigating Energy Transfer Pathways in Lanthanoid Elements. This project aims to investigate fundamental aspects concerning the luminescent properties of compounds containing lanthanoid elements. These elements have extensive use in many high-tech applications, yet essential knowledge related to their properties is still quite limited. This project will elucidate in detail the origin of lanthanoid luminescence through a multidisciplinary approach combining synthetic chemistry and spectroscopy ....Investigating Energy Transfer Pathways in Lanthanoid Elements. This project aims to investigate fundamental aspects concerning the luminescent properties of compounds containing lanthanoid elements. These elements have extensive use in many high-tech applications, yet essential knowledge related to their properties is still quite limited. This project will elucidate in detail the origin of lanthanoid luminescence through a multidisciplinary approach combining synthetic chemistry and spectroscopy. The outcomes of this proposal will expand our limited knowledge in this field, underpinning the future development of novel materials for advanced applications. This will lead to significant economic benefit in Australia as new commercial applications relying on lanthanoid luminescence will be developed.Read moreRead less
Special Research Initiatives - Grant ID: SR0354636
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Australian Computational Molecular Science Network. Computational Molecular Science (CMS) involves the use of theory and computational methods to simulate and visualise molecular systems ranging from small atmospheric species to proteins, nucleic acids, chemical polymers and materials. It represents our most incisive expression of what we understand about the molecular basis of nature. The CMS network will integrate and cross-fertilize both fundamental and application-based expertize in molecula ....Australian Computational Molecular Science Network. Computational Molecular Science (CMS) involves the use of theory and computational methods to simulate and visualise molecular systems ranging from small atmospheric species to proteins, nucleic acids, chemical polymers and materials. It represents our most incisive expression of what we understand about the molecular basis of nature. The CMS network will integrate and cross-fertilize both fundamental and application-based expertize in molecular scale computations in the fields of nanoscience, biomaterials, biotechnology, biomedical science and environmental science. It will uncover and explore critical new interdisciplinary science and create new molecular-based paradigms that will drive advances in these fields over the next decade.Read moreRead less
Gold-based mitochondria targeted chemotherapeutics: mechanistic studies probing interactions with thiol and selenol containing proteins. Cancer affects one in four Australians and prostate cancer is the most commonly diagnosed and second leading cause of male cancer deaths, for which there is currently no effective treatment. Current chemotherapeutics must overcome drug resistance and lack of selectivity between tumour and normal cells. To circumvent these problems we are investigating gold-base ....Gold-based mitochondria targeted chemotherapeutics: mechanistic studies probing interactions with thiol and selenol containing proteins. Cancer affects one in four Australians and prostate cancer is the most commonly diagnosed and second leading cause of male cancer deaths, for which there is currently no effective treatment. Current chemotherapeutics must overcome drug resistance and lack of selectivity between tumour and normal cells. To circumvent these problems we are investigating gold-based compounds, which act by a novel mechanism. The research will lead to new strategies in the design of improved anticancer drugs, an important Australian research priority that will promote and maintain good health. Other benefits arise from training PhD students with interdisciplinary skills for Australian biotechnology industries.Read moreRead less
Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The l ....Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.Read moreRead less
Special Research Initiatives - Grant ID: SR120200004
Funder
Australian Research Council
Funding Amount
$30,000,000.00
Summary
Australian Synchrotron Access Program. The Australian Synchrotron epitomises scientific research excellence in Australian and New Zealand. Its impact spans nearly every research sector. This proposal brings together over 30 Australian universities working together to ensure that world-class peer-reviewed science continues to be performed at the Australian Synchrotron.
Industrial Transformation Research Hubs - Grant ID: IH220100017
Funder
Australian Research Council
Funding Amount
$4,808,669.00
Summary
ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals. Radiopharmaceuticals are emerging as next generation medical technologies for addressing complex health challenges, and their manufacture offers significant economic benefit to Australia. The ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR) aims to establish a manufacturing platform for new medical technologies combining innovations in biotechnology and pharmaceutical science. The progra ....ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals. Radiopharmaceuticals are emerging as next generation medical technologies for addressing complex health challenges, and their manufacture offers significant economic benefit to Australia. The ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR) aims to establish a manufacturing platform for new medical technologies combining innovations in biotechnology and pharmaceutical science. The program addresses industry-led challenges for translation of biologics as molecular radiopharmaceuticals, building capacity in biomanufacturing, radiobiology and radiochemistry. The program establishes a dedicated manufacturing pipeline, future-proofing production and securing supply chain of next generation medical technologies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100051
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
An advanced X-ray facility for surface and in-situ materials characterization. An advanced X-ray facility for surface and in-situ materials characterisation: Materials properties are crucial to the performance of devices and structures, and detailed characterisation at a molecular level is important for optimizing new materials. X-rays are a powerful means of achieving the required level of detail in structural characterisation. The aim of this project is to make available an extremely bright X- ....An advanced X-ray facility for surface and in-situ materials characterization. An advanced X-ray facility for surface and in-situ materials characterisation: Materials properties are crucial to the performance of devices and structures, and detailed characterisation at a molecular level is important for optimizing new materials. X-rays are a powerful means of achieving the required level of detail in structural characterisation. The aim of this project is to make available an extremely bright X-ray source with a suite of advanced analytical tools, including surface structural analysis by reflectometry and grazing incidence diffraction and materials structure determination using powder diffraction and microdiffraction at high and low temperatures. The functions of this facility are broad and its applications include materials science, organic electronics, biomaterials and engineering.Read moreRead less