Discovery Early Career Researcher Award - Grant ID: DE200100949
Funder
Australian Research Council
Funding Amount
$425,364.00
Summary
Metal-free strategies for sustainable light-driven synthesis. Innovation in synthetic chemistry drives the discovery of new life-saving drugs, agrochemicals and functional materials. This project aims to use visible light to access underexploited reactive intermediates and harness their unique reactivity in new sustainable synthetic transformations. The new chemical processes are expected to deliver increased economy, efficiency and precision in the synthesis of bioactive molecules that are inac ....Metal-free strategies for sustainable light-driven synthesis. Innovation in synthetic chemistry drives the discovery of new life-saving drugs, agrochemicals and functional materials. This project aims to use visible light to access underexploited reactive intermediates and harness their unique reactivity in new sustainable synthetic transformations. The new chemical processes are expected to deliver increased economy, efficiency and precision in the synthesis of bioactive molecules that are inaccessible or challenging to prepare with existing technologies. The conceptual and practical outcomes of this project are expected to benefit both academia and industry as the use of hazardous and expensive metal catalysts can be avoided, reducing chemical waste and simplifying purification.Read moreRead less
Hydrogen atom abstraction and addition via proton coupled electron transfer. To prepare new chemicals for the challenges of today, and those in the future, new ways to build materials are needed. These need to deliver maximum complexity (necessary for increasingly sophisticated applications) with minimal economic and environmental cost. In this proposal a family of reactions that are possible using light mediated chemistry will be developed. This approach will allow technologies to be discovered ....Hydrogen atom abstraction and addition via proton coupled electron transfer. To prepare new chemicals for the challenges of today, and those in the future, new ways to build materials are needed. These need to deliver maximum complexity (necessary for increasingly sophisticated applications) with minimal economic and environmental cost. In this proposal a family of reactions that are possible using light mediated chemistry will be developed. This approach will allow technologies to be discovered that will enhance the scientific communities ability to deliver materials designed for a wide array of functions from medicinal chemistry, through to materials science. Read moreRead less
New catalytic alkyne cyclisation strategies for complex molecule synthesis. This project aims to realise new and efficient catalytic chemistry for carbocyclic and heterocyclic synthesis, an immensely important compound family due to their synthetic, biological and material applications. This would be shown by providing new sustainable solutions that minimise resources use and waste production urgently demanded by industry and society to lessen the ecological impact of chemical manufacturing. Exp ....New catalytic alkyne cyclisation strategies for complex molecule synthesis. This project aims to realise new and efficient catalytic chemistry for carbocyclic and heterocyclic synthesis, an immensely important compound family due to their synthetic, biological and material applications. This would be shown by providing new sustainable solutions that minimise resources use and waste production urgently demanded by industry and society to lessen the ecological impact of chemical manufacturing. Expected outcomes include new materials and chemical processes giving Australian industry and academia the cutting-edge in research competitiveness and capacity. This should provide major benefits such as training the next generation of Australian synthetic chemists and wealth creation by supporting the chemical sciences.Read moreRead less
Photoinduced Palladium Catalysis for Next Generation C-H Bond Activation. This project aims to discover new methods for the conversion of carbon-hydrogen bonds in organic molecules as a general strategy in chemical synthesis. A key conceptual advance in this project is the unification of transition metal catalysis and visible light as a powerful tool to activate these traditionally unreactive, yet abundant chemical bonds in alkanes. With application in fields that range from fine chemical produc ....Photoinduced Palladium Catalysis for Next Generation C-H Bond Activation. This project aims to discover new methods for the conversion of carbon-hydrogen bonds in organic molecules as a general strategy in chemical synthesis. A key conceptual advance in this project is the unification of transition metal catalysis and visible light as a powerful tool to activate these traditionally unreactive, yet abundant chemical bonds in alkanes. With application in fields that range from fine chemical production to drug discovery, the overarching aim of this research is to establish new carbon-hydrogen bond activation reactions and to demonstrate that this strategy can be translated to the invention of new pharmaceuticals, agrochemicals and advanced synthetic materials that will have societal impact.Read moreRead less
Next Generation Photocatalysis for Chemical Synthesis and Manufacture. This project aims to discover new methods for the activation of energy demanding bonds in organic molecules as a general strategy in chemical synthesis. A key conceptual advance in this project is the development of multiphoton photoredox catalysis as a powerful tool to activate traditionally unreactive, yet abundant chemical bonds in organic molecules including C-H bonds in alkane and olefin feedstocks. With application in f ....Next Generation Photocatalysis for Chemical Synthesis and Manufacture. This project aims to discover new methods for the activation of energy demanding bonds in organic molecules as a general strategy in chemical synthesis. A key conceptual advance in this project is the development of multiphoton photoredox catalysis as a powerful tool to activate traditionally unreactive, yet abundant chemical bonds in organic molecules including C-H bonds in alkane and olefin feedstocks. With application in fields that range from fine chemical production to drug discovery, the overarching aim of this research is to establish new bond activation reactions and to demonstrate translations to the invention of new pharmaceuticals, agrochemicals and advanced chemical manufacturing processes that will have societal impact.Read moreRead less
Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lip ....Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lipid biology at the cellular and sub-cellular level across a wide range of in vitro and in vivo models. The outcomes of this project should provide significant knowledge to tackle modern societal challenges in healthy ageing, brain pathologies and neurodegenerative diseases.Read moreRead less
A new molecular platform for catalytic synthesis of heterocycles. This project aims to address the lack of efficient methods to prepare cyclic molecules of biological relevance by utilising novel molecular platforms developed in our laboratories. This project expects to generate new cyclic molecules using these innovative molecular platforms by employing catalysts to reduce raw material and energy cost. The expected outcomes of this project include enhanced chemical technology to prepare cyclic ....A new molecular platform for catalytic synthesis of heterocycles. This project aims to address the lack of efficient methods to prepare cyclic molecules of biological relevance by utilising novel molecular platforms developed in our laboratories. This project expects to generate new cyclic molecules using these innovative molecular platforms by employing catalysts to reduce raw material and energy cost. The expected outcomes of this project include enhanced chemical technology to prepare cyclic molecules of pharmaceutical importance and the training of highly skilled PhD students. This should provide significant benefits, such as increased capacity for the development of new pharmaceuticals and advanced materials.Read moreRead less
Doped alumina with tailored material properties for battery applications. This project aims to develop tailored alumina materials for lithium ion battery separators through a novel in-situ approach that will: (1) produce uniform doped alumina for improved safety, (2) target specific surface and bulk material properties to increase the overall performance, and (3) reduce manufacturing costs by integrating the process with new technology developed for the production of high purity alumina. Signifi ....Doped alumina with tailored material properties for battery applications. This project aims to develop tailored alumina materials for lithium ion battery separators through a novel in-situ approach that will: (1) produce uniform doped alumina for improved safety, (2) target specific surface and bulk material properties to increase the overall performance, and (3) reduce manufacturing costs by integrating the process with new technology developed for the production of high purity alumina. Significant advances are proposed for overcoming current manufacturing limitations of doped alumina. Building research capacity and knowledge in battery material manufacturing will benefit a range of industries across Australia, whilst providing new opportunities for growth in local communities.Read moreRead less
Thioamide ligations: new technologies for peptide and protein synthesis. This project aims to develop novel amide-bond forming reactions for the chemical synthesis of peptides and proteins. New peptide ligation strategies, including an asparagine-based ligation and a residue-independent ligation will be developed that exploit the recent discovery of silver-promoted coupling reactions of thioamides. A novel late-stage, chemo-selective assembly of N-glycosylated asparagine residues in peptides and ....Thioamide ligations: new technologies for peptide and protein synthesis. This project aims to develop novel amide-bond forming reactions for the chemical synthesis of peptides and proteins. New peptide ligation strategies, including an asparagine-based ligation and a residue-independent ligation will be developed that exploit the recent discovery of silver-promoted coupling reactions of thioamides. A novel late-stage, chemo-selective assembly of N-glycosylated asparagine residues in peptides and proteins will also be developed. The outcomes of this research will lead to breakthroughs in synthetic methodologies for the assembly and functionalisation of peptides and proteins, thereby enabling access to a range of homogeneous, post translationally modified proteins though total chemical synthesis. These research outcomes will expand Australia's research capability and global competitiveness in the field of biotechnology, delivering significant benefits to the third largest manufacturing sector in Australia.Read moreRead less
High specificity nanosensors for glycobiology . This project aims to develop high specificity glycosensors for identifying and characterising carbohydrates. These glycosensors are expected to generate detailed information on carbohydrate stereochemical structure and how this controls protein-carbohydrate binding and other interactions fundamental to biochemical processes. This innovative nanotechnology aims to deliver a new capability for understanding cellular recognition and antigen binding me ....High specificity nanosensors for glycobiology . This project aims to develop high specificity glycosensors for identifying and characterising carbohydrates. These glycosensors are expected to generate detailed information on carbohydrate stereochemical structure and how this controls protein-carbohydrate binding and other interactions fundamental to biochemical processes. This innovative nanotechnology aims to deliver a new capability for understanding cellular recognition and antigen binding mechanisms. The expected outcomes are new tools for glycobiology and research into carbohydrate structure-function relationships, strengthening Australia’s global reputation in nanosensors with an incisive analytical technology for biomedical sciences and the many industries utilising carbohydrates.Read moreRead less