Manufacturing Nanostructured Polymer Thin Films using Visible Light. This research aims the development of selective photochemical tools driven by different colours of light for the fabrication of nanostructured polymer brush thin films. By using different wavelengths to selectively activate specific chemical reactions, this will enable multiple reactions to be performed simultaneously, significantly streamlining fabrication. Additionally, the increased selectivity offers pathways to more sophis ....Manufacturing Nanostructured Polymer Thin Films using Visible Light. This research aims the development of selective photochemical tools driven by different colours of light for the fabrication of nanostructured polymer brush thin films. By using different wavelengths to selectively activate specific chemical reactions, this will enable multiple reactions to be performed simultaneously, significantly streamlining fabrication. Additionally, the increased selectivity offers pathways to more sophisticated nanoarchitectures in comparison to existing methods. This research will lead to the fabrication of 3D polymer brush architectures with unparalleled precision, which will be of high scientific and industrial value for a diverse range of applications, such as optoelectronics, nanoactuation, and sensing.Read moreRead less
Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microflu ....Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties, a dual-templating method for making targeted silica nanocapsules and new design of in vivo-mimicking 'Tissue Chips' for screening and evaluating the nanocarriers.Read moreRead less
Programming the Microstructure of 3D Printed Objects . This project aims to apply state-of-the-art living polymerisation techniques to 3D printing to efficiently produce customised polymer materials that are tailored at the molecular level. By combining computational modeling and experimental approach, fast and oxygen tolerant photoliving radical polymerisation will be developed and applied to 3D printing. These new systems will produce highly structured polymer materials with remarkable mechani ....Programming the Microstructure of 3D Printed Objects . This project aims to apply state-of-the-art living polymerisation techniques to 3D printing to efficiently produce customised polymer materials that are tailored at the molecular level. By combining computational modeling and experimental approach, fast and oxygen tolerant photoliving radical polymerisation will be developed and applied to 3D printing. These new systems will produce highly structured polymer materials with remarkable mechanical properties. The effect of nanostructure on the macroscopic material properties will be investigated. The intended outcome of this project will produce advanced materials with tailored mechanical properties via streamlined and accessible approaches.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100119
Funder
Australian Research Council
Funding Amount
$424,607.00
Summary
Manipulation of non-wetting droplets for cell culture. We have recently discovered an innovative and interdisciplinary approach for manipulating non-wetting droplets called “liquid marbles” as a platform for three-dimensional cell culture. This project aims to elucidate the fundamental physics underpinning the electrostatic handling concept of this platform technology. The project is expected to deliver an inexpensive but sophisticated cell culture platform that is well-suited for high-throughpu ....Manipulation of non-wetting droplets for cell culture. We have recently discovered an innovative and interdisciplinary approach for manipulating non-wetting droplets called “liquid marbles” as a platform for three-dimensional cell culture. This project aims to elucidate the fundamental physics underpinning the electrostatic handling concept of this platform technology. The project is expected to deliver an inexpensive but sophisticated cell culture platform that is well-suited for high-throughput drug screening and preparing cells for implantation therapy. Significant benefits for end users in pharmaceutical industry, life sciences research and hospitals are expected from the project and the application of the developed technology.Read moreRead less
Soft materials containing hierarchy via 3D sacrificial micro-moulding. The project seeks to develop sophisticated new polymeric materials and devices not possible using current manufacturing techniques. Biomaterials based on hydrogels are ideal substrates for synthetic extra-cellular matrices due to their high water content. However, one of the challenges hindering the use of hydrogels is reproducing the transport properties found in natural tissue with hierarchical features such as vascularisat ....Soft materials containing hierarchy via 3D sacrificial micro-moulding. The project seeks to develop sophisticated new polymeric materials and devices not possible using current manufacturing techniques. Biomaterials based on hydrogels are ideal substrates for synthetic extra-cellular matrices due to their high water content. However, one of the challenges hindering the use of hydrogels is reproducing the transport properties found in natural tissue with hierarchical features such as vascularisation. To address this, the project plans to develop a 3D moulding process for generating soft materials containing precise channels decorated with defined molecules. Intended outcomes include a fundamental understanding of the 3D moulding process, and new polymers and advanced tools for bioengineers for future applications such as tissue transplants, cell guides for treating spinal cord injuries, soft robotics and microfluidic devices to study cancer metastasis. Read moreRead less
Optical tweezers as a micro-rheological probe of soft surfaces. Biomembranes are more than soft containers - their dynamic flexibility plays an important role in cell function, but measurements of mechanical properties of soft surfaces are non-existent. This project develops and applies a new optical tweezers method to measure the flexibility of membranes and its effects upon the friction of nearby particles.
Two-dimensional nanoporous structured high performance gas evolution electrocatalysts. This project aims to develop nano-catalysts with high catalytic activity and rapid gas detachment properties for efficient fuel gas production. Heterogeneous electrocatalytic gas evolution reactions are important for clean energy generation and storage technologies, but high overpotentials caused by slow gaseous products’ detachment from catalyst surface severely hinder their efficiencies. Expected outcomes in ....Two-dimensional nanoporous structured high performance gas evolution electrocatalysts. This project aims to develop nano-catalysts with high catalytic activity and rapid gas detachment properties for efficient fuel gas production. Heterogeneous electrocatalytic gas evolution reactions are important for clean energy generation and storage technologies, but high overpotentials caused by slow gaseous products’ detachment from catalyst surface severely hinder their efficiencies. Expected outcomes include insights into gas bubble formation and evolution during electrocatalysis, effective catalyst structures to mitigate negative effects of gas bubble formation, and improved catalytic efficiency of gas evolution reactions and develop high performance electrocatalysts for fuel gas production.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100185
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
High throughput microbial microculture and single cell analysis facility. High throughput microbial microculture and single cell analysis facility:
To support the emerging research area of microbial heterogeneity and variation in response to conditions, this project aims to establish a facility centred on a 24-microbioreactor system for high throughput microbial culturing. This is designed to be connected to two complementary analysis techniques – flow cytometry and high resolution infra-red mi ....High throughput microbial microculture and single cell analysis facility. High throughput microbial microculture and single cell analysis facility:
To support the emerging research area of microbial heterogeneity and variation in response to conditions, this project aims to establish a facility centred on a 24-microbioreactor system for high throughput microbial culturing. This is designed to be connected to two complementary analysis techniques – flow cytometry and high resolution infra-red microscopy – for the non-destructive measurement of metabolic activities and mapping of constituents of whole cells. This would help us to determine the variation in response between organisms, to guide cell line development and process optimisation for a wide range of biotechnology applications. Expected outcomes may apply to Australia’s brewing, wine, food processing, aquaculture, biofuels, biomedical and biotechnology industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100986
Funder
Australian Research Council
Funding Amount
$401,000.00
Summary
High-performance, portable ion-mobility surface-acoustic wave spectrometry. This project aims to develop a high-performance, cost-effective, palm-portable differential ion mobility spectrometer for universal chemical analysis that operates at atmospheric pressure and consumes minimal power. A significant problem in current analytical chemistry is the lack of rapid and cost-effective methods that can be used in the field for analysis of many different chemical species of environmental and biologi ....High-performance, portable ion-mobility surface-acoustic wave spectrometry. This project aims to develop a high-performance, cost-effective, palm-portable differential ion mobility spectrometer for universal chemical analysis that operates at atmospheric pressure and consumes minimal power. A significant problem in current analytical chemistry is the lack of rapid and cost-effective methods that can be used in the field for analysis of many different chemical species of environmental and biological importance. The project expects to enable the rapid and simultaneous separation and detection of many different ions from complex mixtures with high selectivity and sensitivity. The spectrometer can be implemented in the field for various applications such as atmospheric monitoring, disease diagnosis and chemical weapons detection.Read moreRead less
New bar-encoded polymer microbeads for multiplexed bioanalysis-a quick and high-throughput approach for complex disease diagnosis. Distinguishable new bar-encoded (element-encoded) polymer microbeads associated with a mass spectroscopy-flow cytometer detector provide a novel platform for highly multiplexed biological analysis. Such an approach can simultaneously identify many non-self-agents at low concentrations, which facilitates early-stage complex disease diagnosis.