Porous silicon biosensor for rapid detection of water-borne contaminants. We have recently demonstrated the rapid degradation of porous silicon by certain transition metal complexes known as biomimetic catalysts. The catalysed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. Using this mechanism, we will develop a biosensor for the rapid detection of contaminants (toxins etc.) in water resources. Reservoir w ....Porous silicon biosensor for rapid detection of water-borne contaminants. We have recently demonstrated the rapid degradation of porous silicon by certain transition metal complexes known as biomimetic catalysts. The catalysed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. Using this mechanism, we will develop a biosensor for the rapid detection of contaminants (toxins etc.) in water resources. Reservoir water treatment today is reactive rather than preventive because current analysis is slow. Our biosensor can be turned into a field kit to improve water quality management and prevent acts of deliberate sabotage to the water supply.Read moreRead less
Development of an interferometric nanoscale silicon biosensor. Voelcker et al. have recently demonstrated the rapid degradation of porous silicon by certain supramolecular transition metal complexes known as functional mimics of metalloproteins. The catalyzed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. This project uses porous silicon degradation to develop a biosensor platform capable of detecting a ra ....Development of an interferometric nanoscale silicon biosensor. Voelcker et al. have recently demonstrated the rapid degradation of porous silicon by certain supramolecular transition metal complexes known as functional mimics of metalloproteins. The catalyzed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. This project uses porous silicon degradation to develop a biosensor platform capable of detecting a range of analytes with high sensitivity. The project includes detection of an water-borne toxin, a plant virus and a cancer antigen as demonstrators of its wide applicability. Multiplexing of the biosensor to demonstrate its potential as high-throughput chip sensors is also included.Read moreRead less
Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. ....Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. The development of technological innovations based on fabricated nanomaterials, will also enhance capacity in frontier technology such as nanotechnology, and build Australia’s strength in using new biosensing technologies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346876
Funder
Australian Research Council
Funding Amount
$1,584,000.00
Summary
800 MHz NMR Spectrometer for Molecular Structure-Function Analyses. An 800 MHz high-resolution nuclear magnetic resonance (NMR) spectrometer equipped with a triple-resonance cryoprobe is required to support the research of 5 universities in the NSW/ACT area. The high magnetic field of the spectrometer is necessary for the study of proteins, protein-ligand complexes and other biomolecular systems of molecular weight >30,000. Projects previously inaccessible due to sensitivity, solubility or resol ....800 MHz NMR Spectrometer for Molecular Structure-Function Analyses. An 800 MHz high-resolution nuclear magnetic resonance (NMR) spectrometer equipped with a triple-resonance cryoprobe is required to support the research of 5 universities in the NSW/ACT area. The high magnetic field of the spectrometer is necessary for the study of proteins, protein-ligand complexes and other biomolecular systems of molecular weight >30,000. Projects previously inaccessible due to sensitivity, solubility or resolution problems will become tractable. The increased turn-around times afforded by the high sensitivity of the cryo-enabled spectrometer make it possible to provide access for Australian institutions that would not otherwise have access to comparable equipment.Read moreRead less