Pathophysiology And Alternative Preventative Strategy For Breast Cancer Chemotherapy-induced Bone Loss
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
Combination cytotoxic chemotherapy is the current optimal approach for treating breast cancer in premenopausal women. However, long-term skeletal defects (osteoporosis and fractures) caused by the chemotherapy have become an increasingly serious problem due to its intensified use and improved patient survival rate. This project seeks to elucidate the mechanisms for chemotherapy-induced bone defects and to initiate development of a preventative treatment using natural bioactive micronutrients.
Predicting Drug-drug Interactions Due To Tyrosine Kinase Inhibitors: Inhibition Of Drug Metabolising Enzymes And Transporters
Funder
National Health and Medical Research Council
Funding Amount
$535,495.00
Summary
Tyrosine kinase inhibitors (TKIs) are a new class of anticancer agents. Cancer patients typically receive multiple drugs, for the treatment of cancer and other diseases, increasing the probability of interactions between coadministered drugs. Despite the widespread use of TKIs, their potential to cause drug interactions is poorly understood. Using novel in vitro approaches, this project will identify drug interactions precipitated by TKIs thereby improving drug efficacy and patient safety.
Probiotic Prawn Oral Immunotherapy (ProPIT) For Treatment Of Prawn Allergy
Funder
National Health and Medical Research Council
Funding Amount
$1,865,369.00
Summary
A ‘curative’ food allergy treatment is needed to prevent deaths and improve care. We recently showed that probiotic peanut oral immunotherapy (PPOIT) was highly effective for treating peanut allergy. 82% of PPOIT treated children gained tolerance compared to 4% of the placebo group. We will now test the combined probiotic-food OIT approach for treating prawn allergy. If successful, we will have identified the first treatment for prawn allergy and a platform treatment for other food allergies.
Detection of infrared-biomarkers for the diagnosis and treatment of canine neoplasia. This research hopes to discover infrared-biomarkers for canine cancers using synchrotron infrared and laser light. Many dog cancers are similar to human cancers so cancerous tissues and cells from dogs make excellent models for human cancer research. This project will provide new insights and technological approaches to cancer diagnosis and treatment.
Early Career Industry Fellowships - Grant ID: IE230100437
Funder
Australian Research Council
Funding Amount
$417,237.00
Summary
Nanobubbles for effective and energy efficient water treatment. This project aims to produce new knowledge for developing ozone nanobubbles as a technological option for the water industry where commercially suitable technologies are unavailable. Australian water utilities have identified two key challenges: destruction of micropollutants and natural organic matter in recycled and reservoir water, respectively. New knowledge from the project will allow these water utilities to utilise the extrao ....Nanobubbles for effective and energy efficient water treatment. This project aims to produce new knowledge for developing ozone nanobubbles as a technological option for the water industry where commercially suitable technologies are unavailable. Australian water utilities have identified two key challenges: destruction of micropollutants and natural organic matter in recycled and reservoir water, respectively. New knowledge from the project will allow these water utilities to utilise the extraordinary properties of nanobubbles and the strong oxidation capability of ozone for effective and energy efficient water treatment. Tech-transfer to the industry is guaranteed through a scientifically designed pilot plant for benchmarking against the current state of the art ozonation process and reverse osmosis.Read moreRead less
Towards a cost-effective therapy for osteoporosis using Australian indigenous emu oil. Emu oil has a potent anti-inflammatory property. This project aims to show in rodents whether its use can overcome the inflammatory condition and osteoporosis caused by aging, menopause and cancer chemotherapy. This research could lead to development of an emu oil-based therapy for major health problems and have immense social and economic implications.
Uptake, Sustainability And Impact Of Scaling Up Point-of-care Testing For Sexually Transmissible Infections In Remote And Regional Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,461,788.00
Summary
Aboriginal youth experience unacceptably high rates of curable sexually transmissible infections (STI). Coverage of testing and treatment is insufficient for disease control but could be enhanced via point-of-care (POC) testing. We have been trialling a highly accurate STI/POC diagnostic in the TTANGO (Test, Treat ANd GO) trial. The TTANGO2 partnership will assess the long-term uptake, sustainability and impact of POC testing in 20 Aboriginal health services in regional/remote WA over 5 years.
Early stress experiences and stress resilience in pigs. Animal stress has substantial implications on animal productivity, health and welfare of farm animals and thus farm profitability. This project aims to examine the stress resilience in pigs. Modern pig farming is a major source of food, providing substantial nutritional, social and economic benefits in Australia and worldwide. Animal welfare is of increasing concern to the public, consumers and pork producers, and stress vulnerability is an ....Early stress experiences and stress resilience in pigs. Animal stress has substantial implications on animal productivity, health and welfare of farm animals and thus farm profitability. This project aims to examine the stress resilience in pigs. Modern pig farming is a major source of food, providing substantial nutritional, social and economic benefits in Australia and worldwide. Animal welfare is of increasing concern to the public, consumers and pork producers, and stress vulnerability is an animal health and production problem in the life of the commercial pig. This project will generate new knowledge on early life management to endow stress resilience in pigs, with expected benefits for animal welfare, farm productivity and profitability.Read moreRead less
Preclinical Evaluation Of The Novel Therapeutic Compound APP96-110 In An Ovine Model Of Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$874,734.00
Summary
Traumatic brain injury (TBI) is a significant cause of death and disability, and yet there are currently no effective treatments to improve outcome following such an insult. Our laboratory has developed a novel therapeutic compound, by identifying an endogenous neuroprotective molecule, in the amyloid precursor protein and then identifying the active site and modifying it to improve its efficacy. We will be testing this compound in our sheep model of TBI.
Molecular hallmarks of androgen receptor targeting in prostate cancer. There is a critical need in oncology drug development for better biomarkers of response to prostate cancer therapies, clinically to assist with treatment decision making, and pre-clinically to facilitate translation of emerging agents into clinical practice. Using a unique explant culture model, this project will identify protein and lipid markers that can be used to accurately and reliably assess response to androgen recepto ....Molecular hallmarks of androgen receptor targeting in prostate cancer. There is a critical need in oncology drug development for better biomarkers of response to prostate cancer therapies, clinically to assist with treatment decision making, and pre-clinically to facilitate translation of emerging agents into clinical practice. Using a unique explant culture model, this project will identify protein and lipid markers that can be used to accurately and reliably assess response to androgen receptor (AR)-targeting therapies in human prostate tumours. The identification and functional assessment of these biomarkers will identify those that can be used as surrogate endpoints in clinical trials, facilitate earlier approval of investigational agents and lead to improved options for therapeutic management of prostate cancer.Read moreRead less