Chromosomes are structures that carry genes in all our cells. Every human cell has 46 chromosomes. In the nucleus of eukaryotic cells, DNA is highly folded and compacted with specific proteins into a dynamic polymer called chromatin. Gene expression, chromosome division, DNA replication, and repair all act, not on DNA alone, but on this chromatin template. The discovery that enzymes can (re)organise chromatin into accessible and inaccessible configurations revealed mechanisms that considerably e ....Chromosomes are structures that carry genes in all our cells. Every human cell has 46 chromosomes. In the nucleus of eukaryotic cells, DNA is highly folded and compacted with specific proteins into a dynamic polymer called chromatin. Gene expression, chromosome division, DNA replication, and repair all act, not on DNA alone, but on this chromatin template. The discovery that enzymes can (re)organise chromatin into accessible and inaccessible configurations revealed mechanisms that considerably extend the information potential of the genetic code. In addition, it is now established that chromatin structural features can influence gene expression. In vitro studies support a model in which chromatin functions as a barrier for the access to DNA. Therefore this organization has to be tighly regulated and dynamic to allow the protein-DNA interactions critical for nuclear functions. Importantly genome organisation provides in addition to genetic information another layer of information, so called epigenetic, which by definition means that it is stably inherited throughout cellular divisions, yet it is not encoded genetically. Thus each cell type will display a specific epigenome. We have recently constructed small human minichromosomes, which are much easier to study than the much larger normal chromosomes. The present project proposes to define the epigenetic feature across an entire human chromosome using our minichhromosomes as working models. The outcome will be a significant gain in our knowledge on the processes underlying epigenetic regulation, the organisation of specialised chromatin domain, and behaviour of the chromosomes.Read moreRead less
Significance Of Low-level Mosaicism To Intellectual Disability In Paediatric Disorders
Funder
National Health and Medical Research Council
Funding Amount
$483,402.00
Summary
My vision for the next 4 years is to improve outcomes for children and their families with inherited disorders associated with intellectual disability (ID) and autism through earlier diagnosis and intervention. This is of great importance with annual costs of ID close $14.72 billion to the Australian health system, and missed or delayed diagnoses being a significant problem, as ID is found in 1.7% of births, where a specific cause is currently identified in less than half.
Managing age in organisational context: a comparative study of the meaning of age among managers. Australians are currently being encouraged to work longer to maximise their contribution to the economy but they often report there are organisational barriers to doing so. This study offers a new approach to understanding age focusing on managers and offers a framework of effective strategies for employers in managing age.
Risk and Change In Institutional Fields: The Case Of Industrial Chemicals. This project aims to explore how to manage risk through sustainable organisational strategies and institutional transformations. Chemical risks arise as by-products of economic and technological progress and can cause untold harm to human health and the environment. Using a discursive approach to compare how organisations in Australia and Canada manage chemical risks, this project aims to show how organisations can act as ....Risk and Change In Institutional Fields: The Case Of Industrial Chemicals. This project aims to explore how to manage risk through sustainable organisational strategies and institutional transformations. Chemical risks arise as by-products of economic and technological progress and can cause untold harm to human health and the environment. Using a discursive approach to compare how organisations in Australia and Canada manage chemical risks, this project aims to show how organisations can act as institutional entrepreneurs and introduce sustainable field-level solutions to risk, instead of relying on government regulation to deal with dangerous chemicals. The intended outcomes include the development of a model that identifies the challenges associated with three different risk scenarios – managing established risks, managing emerging risks and eliminating risks – as well as identifying and evaluating strategies to address these challenges.Read moreRead less
An organizational perspective on risk assessment: comparing chemicals management in Australia and Canada. The project compares the managerial and organisational implications of chemical risk assessment in Australia and Canada. It will identify how governments can effectively manage the relationships among different stakeholder organisations involved in risk assessment; and explore how different cultural contexts influence risk assessment.
Price Transparency, Search, and Collusion in Markets. Online search platforms and 'open data' policies are emerging to empower consumers with price information for decision-making in markets, yet also can enable collusive pricing. This project aims to study the competitive impact of search platforms by combining large, real-time datasets on firm pricing and consumer search with natural and field experiments. The project expects to facilitate the development of new models of collusion, consumer s ....Price Transparency, Search, and Collusion in Markets. Online search platforms and 'open data' policies are emerging to empower consumers with price information for decision-making in markets, yet also can enable collusive pricing. This project aims to study the competitive impact of search platforms by combining large, real-time datasets on firm pricing and consumer search with natural and field experiments. The project expects to facilitate the development of new models of collusion, consumer search, and platform adoption. This should yield substantial benefit by modernizing competition policy for the digital age through novel data-driven screens for collusion, and policies to encourage platform adoption and enable consumers’ use of data in decision-making to increase competition in markets.Read moreRead less
Uncertainty and the success of innovation. This proposal outlines an empirically-oriented project, with strong conceptual foundations, that will add significantly to our understanding of the barriers to successful commercial exploitation of innovations in Australia. There is currently no other applied work in this area in Australia of this scope and empirical content. Our approach adopts a rigorous approach to the measurement of innovation and performance, and looks at the effect of uncertainty ....Uncertainty and the success of innovation. This proposal outlines an empirically-oriented project, with strong conceptual foundations, that will add significantly to our understanding of the barriers to successful commercial exploitation of innovations in Australia. There is currently no other applied work in this area in Australia of this scope and empirical content. Our approach adopts a rigorous approach to the measurement of innovation and performance, and looks at the effect of uncertainty on the relationship between the two. The results of this exercise will translate into both government and corporate policy.Read moreRead less
Optimal Policy Design with Entry: A Model of Aggregative Oligopoly Games. This project aims to develop a theory of endogenous market structures using aggregative oligopoly games to engage issues in competition, trade and innovation policy. Effective and innovative policy design is crucial for economic growth and productivity. Policy analysis with endogenous market structures is in need of better tools. The toolkit of aggregative games, in which each player’s profit can be written as a function o ....Optimal Policy Design with Entry: A Model of Aggregative Oligopoly Games. This project aims to develop a theory of endogenous market structures using aggregative oligopoly games to engage issues in competition, trade and innovation policy. Effective and innovative policy design is crucial for economic growth and productivity. Policy analysis with endogenous market structures is in need of better tools. The toolkit of aggregative games, in which each player’s profit can be written as a function of own action and an aggregate variable, would greatly simplify the analysis of oligopoly interaction. This would lead to a tractable but general welfare analysis yielding new results. The framework is designed to allow us to examine complex policy questions in a simplified way, accommodating models with heterogeneous players and entry, and generalising models with different types of competition and demand specification.Read moreRead less
A Model for IT Security Outsourcing of Critical Services. IT security outsourcing is the establishment of a contractual relationship with an outside vendor to assume responsibility for one or more security functions. The decision-making process associated with outsourcing security is complex. To improve the effectiveness of the decision-making process a conceptual model that integrates security benefits, costs and their respective performance measures will be developed. This model will support m ....A Model for IT Security Outsourcing of Critical Services. IT security outsourcing is the establishment of a contractual relationship with an outside vendor to assume responsibility for one or more security functions. The decision-making process associated with outsourcing security is complex. To improve the effectiveness of the decision-making process a conceptual model that integrates security benefits, costs and their respective performance measures will be developed. This model will support management in their aim of overseeing IT security effectively. The research will make a valuable contribution towards determining the impact of IT security outsourcing within Australia.Read moreRead less