Improving Sexual Health In Men With Prostate Cancer: Randomised Controlled Trial Of Exercise And Psychosexual Therapies
Funder
National Health and Medical Research Council
Funding Amount
$583,416.00
Summary
Sexual dysfunction is one of the most common and distressing side effects of prostate cancer. Despite being a critical survivorship care issue, there is a clear gap in knowledge surrounding the optimal treatment of sexual dysfunction in men with prostate cancer. This project examines whether exercise aids in the management of sexual dysfunction and explores if an integrated treatment model incorporating pharmacological, exercise and psychosexual therapies maximises improvement in sexual health.
Cellular Cross-talk Between Liver Progenitor Cells And Hepatic Stellate Cells Is Required For Hepatic Fibrogenesis
Funder
National Health and Medical Research Council
Funding Amount
$618,517.00
Summary
Deloitte Access Economics data proposes the total economic burden of liver disease in Australia in 2012 was >$50 billion. This study will identify how the liver heals itself by inducing liver cell populations which interact to regenerate damaged liver tissue in chronic liver disease. This knowledge may lead to the development of novel therapeutic interventions for the treatment of liver scarring and liver cancer, and to assist in normal liver regeneration following chronic liver disease.
Role Of Hepatic Stellate Cell And Liver Progenitor Cell Interactions In The Regulation Of Wound Healing And Liver Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$620,716.00
Summary
The liver has a remarkable capacity for regeneration following acute and chronic liver injury, however, the mechanisms which facilitate this wound healing are not understood. This project will examine the interactions between different liver cell populations, including hepatic stellate cells (liver fibroblasts) and liver progenitor cells (stem cells of the liver) and will determine which factors regulate inflammation, liver scarring and restitution of liver mass following chronic liver injury.
A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
Composites for thermal expansion matched oxygen electrodes. This project aims to develop high performance composite oxygen electrodes by using both negative thermal expansion materials and electrolyte materials to tailor the thermal expansion and activities of the perovskite-based electrodes for use in reduced temperature solid oxide cells. Such composite electrodes will show highly matched thermal expansion with electrolyte without sacrificing high activity at reduced temperatures. This project ....Composites for thermal expansion matched oxygen electrodes. This project aims to develop high performance composite oxygen electrodes by using both negative thermal expansion materials and electrolyte materials to tailor the thermal expansion and activities of the perovskite-based electrodes for use in reduced temperature solid oxide cells. Such composite electrodes will show highly matched thermal expansion with electrolyte without sacrificing high activity at reduced temperatures. This project seeks to address an important practical issue in the operation of solid oxide power cells - thermal expansion compatibility, which causes poor efficiency outside a narrow temperature band.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100026
Funder
Australian Research Council
Funding Amount
$480,000.00
Summary
A surface characterisation facility. This surface characterisation facility will provide scientists with an understanding of material's surfaces and interfaces. This will lead to a range of new technologies and innovative solutions required to address the many resource and environmental challenges facing our planet now and in the future.
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
Oxide-based high temperature proton exchange membrane fuel cells. Proton exchange membrane fuel cells (PEMFCs) are one of the most efficient energy conversion technologies for producing electricity from fuels such as hydrogen and methanol. Current PEMFCs use precious metal catalysts, and the performance of liquid methanol fuel is disappointingly low due to the inability of polymer or hybrid membranes to operate at temperatures above 160-180 degrees centigrade. This work aims to develop an all ox ....Oxide-based high temperature proton exchange membrane fuel cells. Proton exchange membrane fuel cells (PEMFCs) are one of the most efficient energy conversion technologies for producing electricity from fuels such as hydrogen and methanol. Current PEMFCs use precious metal catalysts, and the performance of liquid methanol fuel is disappointingly low due to the inability of polymer or hybrid membranes to operate at temperatures above 160-180 degrees centigrade. This work aims to develop an all oxide-based PEMFC technology using a recently developed sintered and heteropolyacid functionalised mesoporous silica membrane. The utilisation of all-oxide-PEMFCs using non-precious metal catalysts is expected to significantly enhance the power density, reduce costs, and enhance the commercial viability of PEMFC technologies.Read moreRead less
Future Distribution Grids based on Reconfigurable Smart Microgrid Clusters. This aims of the project are to develop innovative paradigm shifting concepts in which power distributions grids will be self sufficient to look after themselves in the absence of power transmission infrastructure. It is expected that in future several renewable energy based distributed generators (DGs) will be dotted in power distribution systems. It is estimated that within another couple of decades sufficient number o ....Future Distribution Grids based on Reconfigurable Smart Microgrid Clusters. This aims of the project are to develop innovative paradigm shifting concepts in which power distributions grids will be self sufficient to look after themselves in the absence of power transmission infrastructure. It is expected that in future several renewable energy based distributed generators (DGs) will be dotted in power distribution systems. It is estimated that within another couple of decades sufficient number of DGs will be placed in networks so much so that they will be able to meet the load demand of domestic and commercial customers. Therefore the focus of this project is to find innovative approaches in which several microgrids, equipped with single-phase and three-phase DGs can work cohesively while supporting each other.Read moreRead less
New mesoporous materials for use in high temperature proton exchange fuel cell membranes. A novel high temperature proton exchange membrane based on heteropolyacid (HPA) functionalised mesoporous silica will be developed. This research into the fundamental materials science of novel proton exchange membranes is expected to impact significantly on the advancement and commercialisation of portable fuel cell devices.