Tapasin And Major Histocompatibility Complex Class I Antigen Presentation
Funder
National Health and Medical Research Council
Funding Amount
$226,650.00
Summary
An effective T cell response (cellular immune response) to infections is vital to a functional immune system. Normally, proteins are cleaved into small molecules called peptides and these peptides are in turn presented by Major Histocompatibility Complex molecules to T cells. However, we have only partial understanding of what determines the choice of peptides that are finally presented to T cells. Recent research suggests that a molecule called tapasin may also influence the choice of peptides. ....An effective T cell response (cellular immune response) to infections is vital to a functional immune system. Normally, proteins are cleaved into small molecules called peptides and these peptides are in turn presented by Major Histocompatibility Complex molecules to T cells. However, we have only partial understanding of what determines the choice of peptides that are finally presented to T cells. Recent research suggests that a molecule called tapasin may also influence the choice of peptides. This research proposal aims to examine the role of tapasin in this regard. A thorough understanding of the basic principles of peptide presentation to T cells is crucial to the design of effective vaccines. Furthermore it will also broaden our understanding of immunological responses to cancer, autoimmune diseases and infections.Read moreRead less
Ending long-term homelessness permanently: How to make effective links between housing and long-term support. Australian services for homeless people typically provide short to medium-term assistance and accommodation. This approach struggles to meet the complex needs of the long-term homeless. Recently there has been considerable government investment in new approaches to end long-term homelessness, but evidence supporting the efficacy of these approaches is limited. This project builds on a fo ....Ending long-term homelessness permanently: How to make effective links between housing and long-term support. Australian services for homeless people typically provide short to medium-term assistance and accommodation. This approach struggles to meet the complex needs of the long-term homeless. Recently there has been considerable government investment in new approaches to end long-term homelessness, but evidence supporting the efficacy of these approaches is limited. This project builds on a four year Randomised Controlled Trial of the Journey to Social Inclusion pilot-program which was designed to end long-term homelessness. The project aims to track participants for an additional two years. The research aims to provide new knowledge on what practices and factors generate positive outcomes and what factors and practices sustain positive outcomes.Read moreRead less
The Unique Nature Of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10
Funder
National Health and Medical Research Council
Funding Amount
$699,031.00
Summary
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.