Non-urban water governance: rethinking compliance and enforcement. This project aims to critically evaluate the practices and strategies of non-urban water compliance and enforcement in Australia and internationally, to identify and develop innovations for water governance. New law and policy knowledge is expected from its fusion of empirical data and regulatory theory. The project expects to advance applied regulatory theory by identifying improvements in compliance and enforcement to help solv ....Non-urban water governance: rethinking compliance and enforcement. This project aims to critically evaluate the practices and strategies of non-urban water compliance and enforcement in Australia and internationally, to identify and develop innovations for water governance. New law and policy knowledge is expected from its fusion of empirical data and regulatory theory. The project expects to advance applied regulatory theory by identifying improvements in compliance and enforcement to help solve environmental issues. It will also lead to policy reforms for delivering more effective, efficient and politically-acceptable compliance outcomes for non-urban water management that will benefit water regulators and the sustainability and productivity of Australia's agricultural industry.Read moreRead less
Disaster risk reduction practices that leave nobody behind. This project aims to answer critical questions about how to assist people with disabilities (PWD) in disasters, what their support needs are and how they might help themselves to better prepare for disasters. Significance includes coupling a person-centred emergency preparedness tool with cross-sectoral processes to collect and use data about the support needs of PWD in emergencies, increase cross-sector communication and collaboration ....Disaster risk reduction practices that leave nobody behind. This project aims to answer critical questions about how to assist people with disabilities (PWD) in disasters, what their support needs are and how they might help themselves to better prepare for disasters. Significance includes coupling a person-centred emergency preparedness tool with cross-sectoral processes to collect and use data about the support needs of PWD in emergencies, increase cross-sector communication and collaboration between emergency managers and community services, and improve equitable access for PWD to community-level disaster risk reduction (DRR). The expected outcome will be the co-design of effective mechanisms that state & federal decision makers can use to scale-up disability-inclusive DRR across Australia.Read moreRead less
Retention of the Aboriginal health and disability workforce. This project aims to develop evidence-based retention strategies for the Indigenous frontline health and disability workforces. Indigenous people in these roles are critical to improving access to culturally safe and effective services and support for Indigenous Australians. The availability of culturally safe services, interventions and support will assist in closing the gap in health, education and socio-economic outcomes between Ind ....Retention of the Aboriginal health and disability workforce. This project aims to develop evidence-based retention strategies for the Indigenous frontline health and disability workforces. Indigenous people in these roles are critical to improving access to culturally safe and effective services and support for Indigenous Australians. The availability of culturally safe services, interventions and support will assist in closing the gap in health, education and socio-economic outcomes between Indigenous and non-Indigenous Australians. This project aims to uncover the factors that influence Indigenous front line workers to stay in their crucial roles. The findings will be translated into culturally-appropriate workforce retention strategies.Read moreRead less
The global history of organic farming. The first global history of the organic farming movement explains how organic farming changed land-use, government policy and consumer habits. Understanding how this scientific and cultural movement arose, where it succeeded and where it failed, helps to better formulate policy that promotes sustainable agriculture, human health and climate.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
3D Printed Food for People with Swallowing Disability. This project aims to identify ways that 3D food printing (additive manufacturing using real food in a device like a ink-jet printer) could be used to improve the visual appeal of puree meals for people with swallowing difficulty, who make up ~8% of the world's population. This study will be the first to include people with swallowing disability (e.g., related to cerebral palsy, stroke, older age) and their supporters in examining the views a ....3D Printed Food for People with Swallowing Disability. This project aims to identify ways that 3D food printing (additive manufacturing using real food in a device like a ink-jet printer) could be used to improve the visual appeal of puree meals for people with swallowing difficulty, who make up ~8% of the world's population. This study will be the first to include people with swallowing disability (e.g., related to cerebral palsy, stroke, older age) and their supporters in examining the views and experiences of stakeholders on the impact of 3D food printing on quality of life, enjoyment, participation, and safety. Outcomes include new knowledge on factors affecting the implementation of 3D food printing in disability and aged care services, to inform policy, practice, and future research.Read moreRead less
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
Planning for a better life under the National Disability Insurance Scheme (NDIS). This project aims to analyse and define the experiences and expectations of people with disability in rural and remote regions. People accessing the National Disability Insurance Scheme (NDIS) are required to complete a personalised service plan, however despite these reforms, people in rural and remote communities currently experience many challenges with the scheme. Using qualitative research methods, the project ....Planning for a better life under the National Disability Insurance Scheme (NDIS). This project aims to analyse and define the experiences and expectations of people with disability in rural and remote regions. People accessing the National Disability Insurance Scheme (NDIS) are required to complete a personalised service plan, however despite these reforms, people in rural and remote communities currently experience many challenges with the scheme. Using qualitative research methods, the project will investigate people’s experiences engaging with Local Area Coordinators and Planners under the Rural and Remote Strategy 2016-2019 and Aboriginal and Torres Strait Islander Engagement Strategy. The project will provide significant outcomes for Aboriginal and non-Aboriginal people with disability in rural and remote areas, disability service providers, and government and non-government policy makers.Read moreRead less