Development Of Early Warning Systems For Dengue Fever Based On Socio-ecological Factors
Funder
National Health and Medical Research Council
Funding Amount
$327,402.00
Summary
Global climate change has potentially serious effects on the transmission of dengue. An early warning system (EWS) based on socio-ecological factors will be developed to examine where and when outbreaks of dengue are likely to occur and how the future dengue control strategies and prevention efforts need to be applied and strengthened in Australia. This project will provide a platform for future research on developing and implementing an EWS for dengue in the Asia-Pacific region.
Assessment Of The Impact Of Climate Variability On The Transmission Of Ross River Virus Disease
Funder
National Health and Medical Research Council
Funding Amount
$168,125.00
Summary
It is a significant scientific and public health issue to assess the potential impact of climate change on population health. As human-induced global climate change continues, questions about its possible consequences command increasing attention. Australia has a great level of climate variability. Climate zones extend from temperate areas into the tropics and the climate fluctuates over time. Also, it is predicted that Australia lies in the region where the climate pattern will be affected most ....It is a significant scientific and public health issue to assess the potential impact of climate change on population health. As human-induced global climate change continues, questions about its possible consequences command increasing attention. Australia has a great level of climate variability. Climate zones extend from temperate areas into the tropics and the climate fluctuates over time. Also, it is predicted that Australia lies in the region where the climate pattern will be affected most in the 21th century. However, little research has to date been conducted on the potential public health impact of climate variability and change in Australia. This project aims to assess the effect of climate variability on the transmission of Ross River virus infection and other vector-borne diseases which may yield important insights into the potential public health consequences of climate change.Read moreRead less
Genetic Determinants Of Interleukin-10 Response After Infectious Stimuli
Funder
National Health and Medical Research Council
Funding Amount
$276,000.00
Summary
Interleukin-10 is a key protein in the immune defense against infection, being the principal brake for the immune response. An diminished production of interleukin-10 has been implicated as a major cause of a number of devestating medical conditions including septic shock and acute respiratory distress syndrome. An excessive production of interleukin-10 may also be very harmful, and may be the primary cause of the reduction in immune function in many critically ill patients that leads to hospita ....Interleukin-10 is a key protein in the immune defense against infection, being the principal brake for the immune response. An diminished production of interleukin-10 has been implicated as a major cause of a number of devestating medical conditions including septic shock and acute respiratory distress syndrome. An excessive production of interleukin-10 may also be very harmful, and may be the primary cause of the reduction in immune function in many critically ill patients that leads to hospital acquired infections. These potential key roles of interleukin-10 in seriously ill patients makes it an attractive candidate to target for immune therapies. However, past experience with trials of immune-based therapies such as tumor necrosis factor alpha have taught us that we need to be much better at predicting individual immune responses if we are to 'interfere' with the immune system successfully. In the case of interleukin-10 there is substantial individual variation in the amount produced, with studies suggesting up to 70% of this variation is due to genetic differences. This project will establish the basis for this genetic variation by identiying both the genetic markers of high and low interleukin-10 response and the mechanisms by which these genetic markers change interleukin-10 production. This information will not only enable us to better target patients who may need an 'adjustment' of their immune function, but may also lead to novel therapeutic targets or therapeutic agents.Read moreRead less
Projection Of The Impact Of Climate Change On The Transmission Of Ross River Virus Disease
Funder
National Health and Medical Research Council
Funding Amount
$267,645.00
Summary
There is no doubt that mosquito-borne diseases (MBDs) are sensitive to climatic conditions. However, it remains unclear how climate change will influence the distribution and incidence of MBDs. This study aims to use an interdisciplinary and integrated approach to project the impact of future climate change on the transmission of Ross River virus disease - the most common and widespread MBD in Australia, and to provide scientific evidence for developing pulbic health adaptation policies.
Structural And Functional Determinants Of Spatiotemporal Periodicity In Cardiac Impulse Propagation
Funder
National Health and Medical Research Council
Funding Amount
$211,320.00
Summary
Abnormal heart rhythms (cardiac arrhythmias) are responsible for much morbidity and excess mortality in Australia. Although many abnormalities leading to an abnormal heart rhythm may be successfully treated by medications or minimally invasive operative procedures there are several important ones which are not. These include the most common significant cause of an abnormal heart rhythm, atrial fibrillation, and the arrhythmias responsible for approximately half of sudden deaths, ventricular tach ....Abnormal heart rhythms (cardiac arrhythmias) are responsible for much morbidity and excess mortality in Australia. Although many abnormalities leading to an abnormal heart rhythm may be successfully treated by medications or minimally invasive operative procedures there are several important ones which are not. These include the most common significant cause of an abnormal heart rhythm, atrial fibrillation, and the arrhythmias responsible for approximately half of sudden deaths, ventricular tachycardia and ventricular fibrillation. Atrial fibrillation is a leading cause of stroke. Sudden death is associated with aging and is an increasing problem because of the rising mean age of the population. Recent negative attention on the side effects of medications used for the treatment of cardiac arrhythmias has appropriately increased interest in curative approaches requiring no onging medications. These procedures usually rely on mapping electrical activity in the heart and interrupting abnormal electrical pathways using radiofrequency electrical current. The procedures are unsuccessful when existing techniques fail to identify the underlying mechanism responsible for the abnormal heart rhythm or when the source of the abnormal beating cannot be localised within the heart. In this project we investigate the fundamental basis for a new approach to these problems. By examining the variability of the beat rate and the variability of the beat rate at different points within the heart we may be able to identify arrhythmia mechanisms and localise arrhythmia sources. In this project we will examine in groups of cells the structures and types of electrical circuits which give rise to certain types of beat-to-beat variability in the heart. This information will be essential for the interpretation of information obtained in later human studies and the subsequent development of new curative procedures for these problems.Read moreRead less
Very high levels of air pollution kill people. Although air quality is quite good in most Australian cities, the levels of particles are still too high. There are many sources of particles in the air including diesel vehicles and wood fires. There is a National Environment Protection Measure for particles less than 10 thousandths of a millimetre in diameter. However some recent overseas studies have suggested that tiny particles less than 0.1 thousandths of a millimetre might have the greatest e ....Very high levels of air pollution kill people. Although air quality is quite good in most Australian cities, the levels of particles are still too high. There are many sources of particles in the air including diesel vehicles and wood fires. There is a National Environment Protection Measure for particles less than 10 thousandths of a millimetre in diameter. However some recent overseas studies have suggested that tiny particles less than 0.1 thousandths of a millimetre might have the greatest effects on the heart and lungs. We will conduct the first Australian study of the health effects of these tiny particles. Particle counts will be measured in Melbourne by CSIRO using state of the art equipment. Two groups of older subjects will be recruited: patients with chronic lung diseases such as emphysema and patients with heart disease. They will perform regular breathing tests and-or have the electrical activity of their hearts recorded. The recordings will be analysed to detect small variations in heart rate. If we find relationships between particle counts and lung function or heart rate variability, this will provide new evidence of the health effects of air pollution. When the NEPMs are revised, new measures may be required for tiny particles. Particle counts can then be reduced by measures such as better controlling diesel exhaust and more efficient wood stoves.Read moreRead less
Assessing The Impact Of Solar Ultraviolet Radiation On The Immune Response To Primary Vaccination: The AusUVI Study
Funder
National Health and Medical Research Council
Funding Amount
$337,236.00
Summary
The Australian Ultraviolet Radiation and Immunity Study (AusUVI) is an innovative epidemiological study assessing the impact of naturally acquired ultraviolet radiation on the immune response to vaccination with implications for response to infection, vaccination effectiveness and rates of autoimmune disease. Human exposure to ultraviolet radiation may alter in many regions due to climate change related effects on behaviour and clothing patterns, cloud cover and other atmospheric conditions.