A Clinical Trial Of Manipulative Therapy And/or NSAIDs For Significant Acute Low Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$521,625.00
Summary
Acute low back pain is a disabling condition with many sufferers being unable to perform their family or work duties due to severe pain. Treatment of acute LBP is also costly, this condition being one of the most frequent problems managed by general practitioners. Guidelines about how to treat patients with acute low back pain have suggested that advice and paracetamol should be the first line of treatment. In patients with insufficient pain relief two of the most frequently used additional trea ....Acute low back pain is a disabling condition with many sufferers being unable to perform their family or work duties due to severe pain. Treatment of acute LBP is also costly, this condition being one of the most frequent problems managed by general practitioners. Guidelines about how to treat patients with acute low back pain have suggested that advice and paracetamol should be the first line of treatment. In patients with insufficient pain relief two of the most frequently used additional treatments are anti-inflammatory medication and manipulative physiotherapy. However, to date it is not known whether the addition of one or both of these treatments results in faster recovery for the patient. Our clinical trial will clarify whether the addition of (i) anti-inflammatory medication and-or (ii) manipulative physiotherapy, to advice and paracetamol given by the doctor results in a faster recovery for the patient with acute low back pain. This results of this study will make it possible for general practitioners to manage acute low back pain in an evidence-based way.Read moreRead less
The Efficacy Of Manipulation For Recent Onset Neck Pain
Funder
National Health and Medical Research Council
Funding Amount
$393,974.00
Summary
Neck pain is extremely common, with a point prevalence of 46% in the general community. Neck pain can cause significant disability, and is the second most common injury causing people to take time off work. Neck pain and its associated disability clearly poses a substantial social and economic burden. Neck manipulation (high velocity thrust of the joints, often associated with a click) is widely used by physiotherapists for the management of recent onset neck pain, but there is no clear evidence ....Neck pain is extremely common, with a point prevalence of 46% in the general community. Neck pain can cause significant disability, and is the second most common injury causing people to take time off work. Neck pain and its associated disability clearly poses a substantial social and economic burden. Neck manipulation (high velocity thrust of the joints, often associated with a click) is widely used by physiotherapists for the management of recent onset neck pain, but there is no clear evidence for its efficacy. In addition, the use of manipulation is associated with serious, although rare, adverse events such as stroke or even death. The risk-benefit analysis, therefore, does not clearly favour manipulation because efficacy has not been established, while the risks are serious, but infrequent. The findings of the proposed study will clearly and precisely determine the efficacy of manipulation compared with the safer treatment technique of mobilisation (gentle oscillatory pressure applied to the joints), information that is currently unavailable. This information is of vital importance to many different disciplines, including health professionals, insurance companies, and to administrators for development of health policy. Our findings will thus provide evidence-based guidelines for the use of manipulation, and will ultimately lead to safer practice of physiotherapy for neck pain.Read moreRead less
Investigating Linguistic Factors Associated with Stuttering in Cantonese. The aim of this research is to gain new knowledge about the cause of stuttering. The project is a collaboration between experts in stuttering in Australia and Hong Kong. Despite decades of study, the cause of stuttering is still not well understood. Research in English has suggested that changes in emphasis from syllable to syllable can trigger individual moments of stuttering. However, Cantonese is very different from Eng ....Investigating Linguistic Factors Associated with Stuttering in Cantonese. The aim of this research is to gain new knowledge about the cause of stuttering. The project is a collaboration between experts in stuttering in Australia and Hong Kong. Despite decades of study, the cause of stuttering is still not well understood. Research in English has suggested that changes in emphasis from syllable to syllable can trigger individual moments of stuttering. However, Cantonese is very different from English, being a tonal and syllabic language, and uncovering the linguistic triggers of stuttering in Cantonese will yield new insight into the complex causality of this disabling condition.Read moreRead less
About 1 in 10 Australians have persisting or chronic low back pain. Most are managed in primary care and the most frequently prescribed treatment is exercise. Chronic low back pain remains a major health problem because not all patients respond to each treatment so on average treatment effects are small. At present there are no guidelines to help clinicians select the best treatment for a patient. As a result a lot of time and money is wasted on treatments which ultimately fail to help the patie ....About 1 in 10 Australians have persisting or chronic low back pain. Most are managed in primary care and the most frequently prescribed treatment is exercise. Chronic low back pain remains a major health problem because not all patients respond to each treatment so on average treatment effects are small. At present there are no guidelines to help clinicians select the best treatment for a patient. As a result a lot of time and money is wasted on treatments which ultimately fail to help the patient. We have begun a research program to solve this primary health care problem. We have focussed on exercise because the treatment is widely available in primary care and of modest cost. The program includes basic research to understand the mechanism of action of exercise and clinical trials testing the effectiveness of different types of exercise. The proposed study falls into the latter category, and is a direct comparison of the two most promising types of exercise used in Australia. The study will also identify clinical features that modify treatment effects, a finding that will allow clinicians to identify which type of exercise is more likely to be effective for an individual patient. This study offers a potential solution to a major health problem with enormous economic and social costs.Read moreRead less
Coupling biophotonic modalities with machine based recognition systems for disease diagnosis. This project will develop new ways to diagnose canine cancer, malaria and atherosclerosis using infrared-based technology and sophisticated pattern recognition techniques in the hope to discover infrared biomarkers that will lead to early diagnosis of the disease and ultimately save lives.
Defining the molecular and cellular mechanisms of beta cell dysfunction. This project will investigate the influence of environment in the functional adaptation and maladaptation of pancreatic beta cells in diabetes. The research will define the molecular and cellular mechanisms linking environmental triggers such as obesity, high fatty acid levels and hyperglycaemia to beta cell dedifferentiation and dysfunction.
Discovery Early Career Researcher Award - Grant ID: DE120100402
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The effectiveness of intervention in communication and safety climate in the operating room. This project will evaluate the effectiveness of an educational intervention on teamwork behaviours in surgery. It will deliver beneficial effects for communication in service delivery, safety and patient care in support of health care in high risk environments.
Better prevention and management of disabling back pain. This project will establish a program of back pain research within an inter-disciplinary research centre focused on the prevention and management of physical disability.
Special Research Initiatives - Grant ID: SR140100001
Funder
Australian Research Council
Funding Amount
$35,000,000.00
Summary
The Juvenile Diabetes Research Foundation Australian Type 1 Diabetes Research Network and Program. This Proposal continues the development of the initial Type 1 Diabetes Clinical Research Network (CRN), launched by JDRF in June 2011 with a $5m grant from the Australian Government.
The principal goal of the CRN is to positively impact the life of people with T1D in Australia through the support and promotion of clinical research. A further electoral commitment of $35m over 5 years will enable f ....The Juvenile Diabetes Research Foundation Australian Type 1 Diabetes Research Network and Program. This Proposal continues the development of the initial Type 1 Diabetes Clinical Research Network (CRN), launched by JDRF in June 2011 with a $5m grant from the Australian Government.
The principal goal of the CRN is to positively impact the life of people with T1D in Australia through the support and promotion of clinical research. A further electoral commitment of $35m over 5 years will enable further progress towards finding a cure for T1D, including delivering better and faster access to new therapies and treatments that can help prevent and manage the disease.
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