Pathogenic Repeat Expansions In Ataxia: Advancing Gene Discovery And Genetic Diagnosis
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Hereditary ataxia is a severe neurological disorder that results in impaired coordination and balance and affects 1 in 20,000 Australians. Ataxias are often caused by complex genetic mutations called repeat expansions (RE), which are difficult to detect. Therefore, genetic diagnosis of ataxia remains limited and poorly accessible, leading to a gap in clinical care. In this study, we will utilise modern advances in genetic sequencing technology to diagnose and discover ataxias caused by REs.
New Insights on Modelling Time Trends with Panel Data: Theory and Practice. This project aims to tackle important challenges in time trend modelling by taking advantage of panel data structures. This project expects to propose flexible models in time trend modelling to retrieve reliable inference. The expected outcomes include innovative econometric models and methods that have a wide range of applications, and are particularly suited for empirical problems within large and complex systems. This ....New Insights on Modelling Time Trends with Panel Data: Theory and Practice. This project aims to tackle important challenges in time trend modelling by taking advantage of panel data structures. This project expects to propose flexible models in time trend modelling to retrieve reliable inference. The expected outcomes include innovative econometric models and methods that have a wide range of applications, and are particularly suited for empirical problems within large and complex systems. This will provide significant benefits to all fields in which data displays any form of trending behaviour. The proposed model is used to evaluate the economic consequences of climate change and global housing market contagion, which provide strong evidence-based insights to the environmental and economic policies in Australia.Read moreRead less
Computational modelling of nanofluids for industrial applications. The use of nanoparticles in heat transfer fluids, then known as nanofluids, increases their specific heat and thermal conductivity. Recent experimental works highlight that anomalous transport phenomena are evident in nanofluids that cannot be adequately described by classical conservation laws. We will extend these conservation laws to incorporate fractional operators to capture the fluid memory effects and the impact of particl ....Computational modelling of nanofluids for industrial applications. The use of nanoparticles in heat transfer fluids, then known as nanofluids, increases their specific heat and thermal conductivity. Recent experimental works highlight that anomalous transport phenomena are evident in nanofluids that cannot be adequately described by classical conservation laws. We will extend these conservation laws to incorporate fractional operators to capture the fluid memory effects and the impact of particle clustering. Computational modelling and experimental investigations will be undertaken to identify the heat transfer mechanisms of various nanofluids. The outcomes of the work will increase knowledge on nanofluids and offer a significant opportunity to improve the efficiency of many thermal engineering systems.Read moreRead less
Measuring uncertainty in global housing markets and its risk to Australia. This project aims to develop and construct a measure of systemic risk for the national real-estate markets in Australia, and its main trading partners, namely China, Japan, New Zealand, United Kingdom and United States of America. Recently developed methodology will be used to investigate how real estate risks migrate across these countries over time, and during periods of financial turbulence. This methodology is intende ....Measuring uncertainty in global housing markets and its risk to Australia. This project aims to develop and construct a measure of systemic risk for the national real-estate markets in Australia, and its main trading partners, namely China, Japan, New Zealand, United Kingdom and United States of America. Recently developed methodology will be used to investigate how real estate risks migrate across these countries over time, and during periods of financial turbulence. This methodology is intended to be employed as part of a market stability surveillance program and for assessing the impact of real-estate risk on the overall economy. Early detection of the onset of future housing bubble collapses would be of significant benefit to policy makers, Australia’s trading partners, the real estate industry and ultimately home buyers.Read moreRead less
Advanced Bayesian Inversion Algorithms for Wave Propagation. This project aims to improve algorithms for detecting hidden items by developing new computational mathematical techniques capable of reconstructing the shape and location of objects using electromagnetic waves. This project expects to generate new knowledge in the areas of Bayesian Inversion and computational wave propagation. Expected outcomes of this project are algorithms that can be developed for use in nonintrusive radio wave sec ....Advanced Bayesian Inversion Algorithms for Wave Propagation. This project aims to improve algorithms for detecting hidden items by developing new computational mathematical techniques capable of reconstructing the shape and location of objects using electromagnetic waves. This project expects to generate new knowledge in the areas of Bayesian Inversion and computational wave propagation. Expected outcomes of this project are algorithms that can be developed for use in nonintrusive radio wave security scanners. This should provide benefits such as the capability to scan a crowd without a checkpoint, which will have the potential to improve security in public places.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100052
Funder
Australian Research Council
Funding Amount
$2,107,500.00
Summary
Breakthrough methods for noncommutative calculus. This project aims to solve hard, outstanding problems which have impeded our ability to progress in the area of quantum or noncommutative calculus. Calculus has provided an invaluable tool to science, enabling scientific and technological revolutions throughout the past two centuries. The project will initiate a program of collaboration among top mathematical researchers from around the world and bring together two separate mathematical areas int ....Breakthrough methods for noncommutative calculus. This project aims to solve hard, outstanding problems which have impeded our ability to progress in the area of quantum or noncommutative calculus. Calculus has provided an invaluable tool to science, enabling scientific and technological revolutions throughout the past two centuries. The project will initiate a program of collaboration among top mathematical researchers from around the world and bring together two separate mathematical areas into a powerful new set of tools. The outcomes from the project will impact research at the forefront of mathematical physics and other sciences and enhance Australia’s reputation and standing.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100260
Funder
Australian Research Council
Funding Amount
$457,378.00
Summary
Refugee moral injury: Linking interpersonal trauma and social functioning. This project aims to understand how moral beliefs about past interpersonal traumatic experiences (e.g., torture, rape) are associated with social outcomes considered to be crucial in successful refugee resettlement. This project will investigate the causal impact of these moral beliefs on social adaptation and whether these beliefs are malleable. The project will be a better understanding of how moral beliefs can impact r ....Refugee moral injury: Linking interpersonal trauma and social functioning. This project aims to understand how moral beliefs about past interpersonal traumatic experiences (e.g., torture, rape) are associated with social outcomes considered to be crucial in successful refugee resettlement. This project will investigate the causal impact of these moral beliefs on social adaptation and whether these beliefs are malleable. The project will be a better understanding of how moral beliefs can impact refugees' abilities to navigate and engage with novel social environments. The outcomes of this project will assist service providers and policy makers to understand why some refugees are able to adapt more successfully than others and provide practical tools for improving social outcomes. Read moreRead less
Econometric studies of the dynamics of loneliness and social isolation. This project aims to provide new insights into the socioeconomic dynamics of loneliness and social isolation using advanced econometric modelling techniques applied to longitudinal data from Australia and the UK. This project will apply advanced econometric modelling techniques to data from four nationally-representative longitudinal surveys to substantively help address these knowledge gaps, giving policy-makers new informa ....Econometric studies of the dynamics of loneliness and social isolation. This project aims to provide new insights into the socioeconomic dynamics of loneliness and social isolation using advanced econometric modelling techniques applied to longitudinal data from Australia and the UK. This project will apply advanced econometric modelling techniques to data from four nationally-representative longitudinal surveys to substantively help address these knowledge gaps, giving policy-makers new information about how to address these growing societal concerns. The expected outcomes will provide policy-makers with a better understanding of the socioeconomic triggers for loneliness and social isolation; quantify the costs of loneliness and social isolation on health and wellbeing; and identify policy interventions aimed at reducing loneliness and social isolation.Read moreRead less
A Functional Analysis of the Hypoelliptic Laplacian. Strike a bell, a sphere, or any geometrical object, and it rings. The frequencies of ringing are the mathematical spectrum, which encodes deep secrets about the shape of the object. The spectrum of the hypoelliptic laplacian is known to carry deep truths in mathematics and physics, but it remains difficult to understand. We propose a new analytic foundation, which will replace the so far non-analytical ad hoc approach, and make accessible many ....A Functional Analysis of the Hypoelliptic Laplacian. Strike a bell, a sphere, or any geometrical object, and it rings. The frequencies of ringing are the mathematical spectrum, which encodes deep secrets about the shape of the object. The spectrum of the hypoelliptic laplacian is known to carry deep truths in mathematics and physics, but it remains difficult to understand. We propose a new analytic foundation, which will replace the so far non-analytical ad hoc approach, and make accessible many new results. It is key to better understanding differential equations which lie at the boundary between quantum mechanics and the classical world. This will pave the way for Australian leadership in a new century of differential equations and geometry, and training of young mathematicians.Read moreRead less
Promoting Child and Carer Wellbeing and Placement Stability in Kinship Care. Kinship care is the fastest growing out-of-home care placement in Australia, yet least supported. This project aims to implement and evaluate an attachment and trauma-based program for kinship carers, explore its suitability for cultural adaptation for Indigenous families and co-design practical resources to promote program sustainability and trauma-informed practice. This project is Australia’s first randomised trial o ....Promoting Child and Carer Wellbeing and Placement Stability in Kinship Care. Kinship care is the fastest growing out-of-home care placement in Australia, yet least supported. This project aims to implement and evaluate an attachment and trauma-based program for kinship carers, explore its suitability for cultural adaptation for Indigenous families and co-design practical resources to promote program sustainability and trauma-informed practice. This project is Australia’s first randomised trial of a tailored program for kinship carers and expects to generate vital knowledge on evidence-based support. Via implementing an innovative program for kinship carers in statutory child protection, this project should build capacity for research-based practice and benefit family wellbeing and placement outcomes in kinship care.Read moreRead less