Australian Partnership (for) Preparedness Research On InfectiouS (disease) Emergencies (APPRISE)
Funder
National Health and Medical Research Council
Funding Amount
$4,996,416.00
Summary
We have assembled national experts in clinical, laboratory and public health research to ensure Australia is equipped for a coordinated, effective and evidence based response to infectious diseases. This multidisciplinary team will create and share new knowledge to detect, prevent and manage emerging infection threats. We will train a robust cross-sectoral work force and develop sustainable research capacity integrated within the health system to ensure national and regional health security.
Intermittent Preventive Treatment In Pregnancy With Sulphadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine To Reduce Adverse Pregnancy Outcomes And Prevent Malaria In Papua New Guinea: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$2,938,453.00
Summary
Millions of pregnancies are complicated by malaria worldwide. Monthly sulphadoxine-pyrimethamine (SP) treatments, the current treatment strategy, no longer protects from malaria but improves birth outcomes through non-malarial effects. Dihydroartemisinin-piperaquine clears malaria but babies are smaller compared to women who received SP. A clinical trial of their combination has potential to substantially improve health outcomes for women and babies in Papua New Guinea and beyond.
Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We ....Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We will generate antibody fragments that bind these MP and express them in tomato. We will analyse antibody expression in tomato and study their association with the phytoplasma membrane. Transgenic plants will be inoculated with phytoplasma and monitored for resistance. This work represents a major step towards engineering resistance to phytoplasmas.Read moreRead less
Managing acid mine drainage in northern Australia using microbial mats. One of the most difficult environmental issues for the mining industry is acid mine drainage (AMD) that can lead to significant environmental damage. This project aims to identify microbes and characterise their roles in AMD formation in north Australia. We will use our new knowledge to design and trial microbial mats for the treatment of AMD. A successful AMD microbial treatment technology will minimise the risk of acid run ....Managing acid mine drainage in northern Australia using microbial mats. One of the most difficult environmental issues for the mining industry is acid mine drainage (AMD) that can lead to significant environmental damage. This project aims to identify microbes and characterise their roles in AMD formation in north Australia. We will use our new knowledge to design and trial microbial mats for the treatment of AMD. A successful AMD microbial treatment technology will minimise the risk of acid runoff and metal seepage into rivers and through groundwater. AMD treatment technology we develop in the tropics where we experience the extremes of dry and wet seasons will require only minor modification to operate in temperate climates however the reverse is not true. Read moreRead less
A Randomised Controlled Trial Of Alternative Treatments To Intramuscular Penicillin For Impetigo In Aboriginal Children
Funder
National Health and Medical Research Council
Funding Amount
$1,326,182.00
Summary
We will conduct clinical trials to find an effective, simple and cheap oral alternative to injected penicillin for skin sores which could become the universal standard of care whether the patient is in Melbourne or Milingimbi. It would also likely be adopted by the World Health Organization as a standard of care for developing countries. This would lead directly to a reduced burden of skin sores and their complications. It would also open the way for studies to explore even simpler regimens.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989147
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to bi ....Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to biomolecular research in medicine, agriculture and environmental biology, thereby providing major benefits to the wider community. The application will enhance existing genomic technologies by substantially increasing the scope of experiments that can be performed leading to important advances in gene discovery.Read moreRead less
Coastal monitoring using metal resistant microbes. We will develop an early warning, rapid biological assessment (RBA) for sediment toxicity that can be used alongside chemical tests to detect sub-chronic changes in the environment. The assessment will be validated by extensive testing of impacted sediment. We will show how the RBA fits into existing decision trees defined by the Australian and New Zealand Environment and Conservation Council (ANZECC) 2000 Guidelines. The biological tests result ....Coastal monitoring using metal resistant microbes. We will develop an early warning, rapid biological assessment (RBA) for sediment toxicity that can be used alongside chemical tests to detect sub-chronic changes in the environment. The assessment will be validated by extensive testing of impacted sediment. We will show how the RBA fits into existing decision trees defined by the Australian and New Zealand Environment and Conservation Council (ANZECC) 2000 Guidelines. The biological tests resulting from this project will be as rapid and straightforward as existing chemical tests, which will facilitate industry acceptance. The project has strong industry involvement from mining companies, the Environment Protection Agency (EPA) and traditional owners. These partners will guide this project and facilitate communication to the wider industry to aid acceptance and uptake.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100014
Funder
Australian Research Council
Funding Amount
$4,996,503.00
Summary
ARC Research Hub for Supercharging Tropical Aquaculture Through Genetic Solutions. This project will deliver the genetic knowledge to instigate world-leading and highly productive breeding programs for five tropical aquaculture species (barramundi, pearl oyster, prawn, grouper and marine algae) in northern Australia. It will integrate cutting edge genetic and genomic approaches into innovative aquaculture enterprises and will establish a novel understanding of the genetic basis of disease resist ....ARC Research Hub for Supercharging Tropical Aquaculture Through Genetic Solutions. This project will deliver the genetic knowledge to instigate world-leading and highly productive breeding programs for five tropical aquaculture species (barramundi, pearl oyster, prawn, grouper and marine algae) in northern Australia. It will integrate cutting edge genetic and genomic approaches into innovative aquaculture enterprises and will establish a novel understanding of the genetic basis of disease resistance and how the production environment interfaces with the bacterial microbiome, pathogens and water quality to cause disease. Outcomes will lead to increased productivity, international competitiveness, and lowered disease risk and significantly expand Australia's capacity in the aquaculture sector.Read moreRead less
A framework for adapting child interview protocols in complex cases. This project aims to develop–in collaboration with Aboriginal and other industry co-researchers–a ‘how to’ framework for effectively adapting standard child abuse interview protocols to accommodate the complexities that create barriers to disclosure. Complex cases necessitate interview adaption, but it requires systematic guidance and an interdisciplinary, practitioner-driven approach to be effective. This innovative framework ....A framework for adapting child interview protocols in complex cases. This project aims to develop–in collaboration with Aboriginal and other industry co-researchers–a ‘how to’ framework for effectively adapting standard child abuse interview protocols to accommodate the complexities that create barriers to disclosure. Complex cases necessitate interview adaption, but it requires systematic guidance and an interdisciplinary, practitioner-driven approach to be effective. This innovative framework is expected to have long-term benefits for services that support children’s well-being, through improvements in the quality of evidence underpinning decisions. By enhancing interviewer capability, there will also be fewer cases prematurely exiting the justice system before forensic interview or investigation.Read moreRead less