Testosterone Intervention For The Prevention Of Diabetes Mellitus In High Risk Men: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$5,054,654.00
Summary
Type 2 diabetes (T2DM) is increasingly common, costly and deadly. Some men at risk of T2DM have low testosterone (T) levels. Our preliminary data suggests that T treatment may prevent the development of T2DM, and improve cardiovascular and sexual function, body composition and bone density, and mood. This remains to be fully tested in a randomized placebo-controlled trial, and this project will do so in a 2-year study of T treatment compared to placebo in men at risk of T2DM participating in a l ....Type 2 diabetes (T2DM) is increasingly common, costly and deadly. Some men at risk of T2DM have low testosterone (T) levels. Our preliminary data suggests that T treatment may prevent the development of T2DM, and improve cardiovascular and sexual function, body composition and bone density, and mood. This remains to be fully tested in a randomized placebo-controlled trial, and this project will do so in a 2-year study of T treatment compared to placebo in men at risk of T2DM participating in a lifestyle program.Read moreRead less
Reducing The Greatest Uncertainty In Radiotherapy.
Funder
National Health and Medical Research Council
Funding Amount
$594,197.00
Summary
The weakest link in radiotherapy is defining treatment volumes (contouring). Lack of accuracy and consistency in clinical trial contouring has been shown to result in reduced patient outcomes. Manual review of contouring is resource intensive, expensive and for advanced treatments unachievable in a timely fashion. We will assess an automated approach to contouring assessment using 4 clinical trial datasets, changing practice for future studies and enabling consistent assessment in the clinic.
The Treatment Of BOoking Gestational Diabetes Mellitus Study: The TOBOGM Study
Funder
National Health and Medical Research Council
Funding Amount
$2,197,280.00
Summary
Gestational diabetes mellitus (GDM) related pregnancy complications are reduced with treatment from 24-28 weeks pregnant. Many women are diagnosed/treated earlier without evidence of benefit and possible risk of harm. In TOBOGM women under 20 weeks pregnant with mildly raised blood glucose will be allocated by chance to either immediate treatment, or awaiting a repeat diabetes test at 24-28 weeks pregnant to decide treatment. Harmful and beneficial effects on mother and baby will be compared.
Promoting Child and Carer Wellbeing and Placement Stability in Kinship Care. Kinship care is the fastest growing out-of-home care placement in Australia, yet least supported. This project aims to implement and evaluate an attachment and trauma-based program for kinship carers, explore its suitability for cultural adaptation for Indigenous families and co-design practical resources to promote program sustainability and trauma-informed practice. This project is Australia’s first randomised trial o ....Promoting Child and Carer Wellbeing and Placement Stability in Kinship Care. Kinship care is the fastest growing out-of-home care placement in Australia, yet least supported. This project aims to implement and evaluate an attachment and trauma-based program for kinship carers, explore its suitability for cultural adaptation for Indigenous families and co-design practical resources to promote program sustainability and trauma-informed practice. This project is Australia’s first randomised trial of a tailored program for kinship carers and expects to generate vital knowledge on evidence-based support. Via implementing an innovative program for kinship carers in statutory child protection, this project should build capacity for research-based practice and benefit family wellbeing and placement outcomes in kinship care.Read moreRead less
Uncovering The Basis Of Inflammatory And Immunodeficiency Diseases
Funder
National Health and Medical Research Council
Funding Amount
$15,718,075.00
Summary
A world-class team from 3 institutions, spanning disciplines of clinical and experimental immunology, therapeutics, signalling and genetics, will identify how immune and inflammatory responses are controlled in both health and disease. The major outcomes of this work will be the generation of new knowledge, concepts and approaches to diagnose, prevent and treat the major human health problems of autoimmune diseases, inflammation, allergy and immunodeficiency.
Fishing For Change: A Social Marketing Approach To Reduce The Recreational Harvest Of Snapper And Pearl Perch In Queensland
Funder
Fisheries Research and Development Corporation
Funding Amount
$342,500.00
Summary
Snapper and pearl perch are depleted in Queensland and further reduction in fishing pressure is needed to rebuild stocks back to target levels. The Queensland Government announced actions to improve stocks on 1 Sep 2019 , which followed the announcement that they would also introduce Fishing Aggregation Devices (FADs). Given previous regulatory approaches have been unsuccessful in improving stocks of both species, it is proposed that regulatory changes, complemented by the implementation of acti ....Snapper and pearl perch are depleted in Queensland and further reduction in fishing pressure is needed to rebuild stocks back to target levels. The Queensland Government announced actions to improve stocks on 1 Sep 2019 , which followed the announcement that they would also introduce Fishing Aggregation Devices (FADs). Given previous regulatory approaches have been unsuccessful in improving stocks of both species, it is proposed that regulatory changes, complemented by the implementation of action mapping and social marketing, may be more effective.
Social marketing delivers innovative solutions that people value and that support desired outcomes. It draws on behavioural science and a psychology-based understanding of how and why people behave, what motivates them to change and what prevents behaviour change. Work in Australia has documented the use of behavioural incentives to encourage voluntary compliance of recreational fishers as well as testing social norms as a tool to encourage compliance within an experimental recreational fishery setting. This work sets a foundation to apply the approach to Queensland recreational fishing.
The Queensland Government’s announcement that it will invest $1 million in FADs offers an opportunity to change recreational harvesting behaviour. FADs can attract pelagic species increasing the diversity of fish species recreational anglers can target and therefore could shift fishing effort away from more vulnerable demersal species (e.g. snapper and pearl perch).
This project will use a social marketing approach that initially focuses on understanding if and how recreational fishers can be motivated and moved to use FADs as a strategy to reduce snapper and pearl perch fishing. This project will also consider a full range of strategies and behaviours and their relative potential to help reduce snapper and pearl perch recreational harvests.
A key challenge in addressing the issue is the numerous and diverse stakeholders with an interest in recreational fishing – many with conflicting agendas. Approaches that engage a broad cross-section of stakeholders together can identify priorities for action and generate solutions to achieve the outcomes sought. Objectives: 1. Engage with stakeholders to develop a shared sense of responsibility, capture knowledge and identify potential solutions. 2. Develop and test a behaviour change program targeted at recreational fishers that aims to reduce the recreational harvest of snapper and pearl perch in Queensland. 3. Identify the most effective behaviour change interventions that could be further rolled out in Queensland or in other states or to target other fish. 4. Share knowledge and ownership of a behaviour change approach with key stakeholders. Read moreRead less
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Patient and nurse outcomes and the cost of nurses' turnover in Australian hospitals. An adequate supply of nurses is fundamental to all of the National Health Priority disease areas where quality care cannot be delivered without an adequate number of motivated nurses. Designing cost-effective methods of retaining nurses requires understanding reasons why they leave the workforce and the impact this has on patient care and system costs. The findings will assist policy makers and workforce planner ....Patient and nurse outcomes and the cost of nurses' turnover in Australian hospitals. An adequate supply of nurses is fundamental to all of the National Health Priority disease areas where quality care cannot be delivered without an adequate number of motivated nurses. Designing cost-effective methods of retaining nurses requires understanding reasons why they leave the workforce and the impact this has on patient care and system costs. The findings will assist policy makers and workforce planners at both local and national levels, to design strategies to effectively recruit and retain nurses as demands for health care and market competition for staff both increase.Read moreRead less
Special Research Initiatives - Grant ID: SR0567658
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
A cross-disciplinary collaboration to develop a national system for real-time detection of Adverse Drug Reactions using linked Australian health data. Our aim is to use existing administrative health data in the evidence-based, cost-effective and privacy-respecting discovery of Adverse Drug Reactions. This research is of vital importance, since adverse reactions to medicines currently represent one of the leading causes of hospitalisation and death in Australia. In a groundbreaking collaboration ....A cross-disciplinary collaboration to develop a national system for real-time detection of Adverse Drug Reactions using linked Australian health data. Our aim is to use existing administrative health data in the evidence-based, cost-effective and privacy-respecting discovery of Adverse Drug Reactions. This research is of vital importance, since adverse reactions to medicines currently represent one of the leading causes of hospitalisation and death in Australia. In a groundbreaking collaboration, we have successfully shown that large linked, administrative data sets are sufficiently rich to enable discovery of adverse drug reactions, but our analytic tools are at an early developmental stage. The outcome of this project would be innovative, effective and sustainable analytic tools for the discovery of unexpected associations between drugs and medical events.Read moreRead less
Tactical Research Fund: Reference Points For The Queensland Scallop Fishery
Funder
Fisheries Research and Development Corporation
Funding Amount
$30,984.70
Summary
Reference points are essential for the effective management of any large fishery. The spatially complex nature of scallop fisheries makes the construction of robust reference points difficult. FRDC project 1999/120, "Reference point management and the role of catch-per-unit-effort in prawn and scallop fisheries", concluded that "new types of data are essential to improve the accuracy of stock assessments, such as spatial indices of abundance collected through fishery independent sampling and VMS ....Reference points are essential for the effective management of any large fishery. The spatially complex nature of scallop fisheries makes the construction of robust reference points difficult. FRDC project 1999/120, "Reference point management and the role of catch-per-unit-effort in prawn and scallop fisheries", concluded that "new types of data are essential to improve the accuracy of stock assessments, such as spatial indices of abundance collected through fishery independent sampling and VMS", and that "more accurate and robust reference points may exist using these data". FRDC project 2006/024, "Harvest strategy evaluation to optimise the sustainability and value of the Queensland scallop fishery", made effective use of both these data types to answer questions about the optimal timing of spatial closures and other management strategies. The proposed TRF project will build on this work by completing the path to adoption of the recommendations contained in the 2006/024 report, and noted by the FRDC external reviewer (review attached). In particular this will involve using the already constructed HSE framework to devise and test robust reference points.
In order to adopt the recommendations from FRDC project 2006/024 in the current review of management arrangements for the fishery, Fisheries Queensland requires this additional work on sustainability reference points. This work on the sustainabililty reference points is required to be completed by August 2010 with a final report available no later than September 2010. Objectives: 1. Propose and construct a set of reference points for the scallop fishery (e.g. target and limit effort) 2. Test the reference points in the (already constructed) MSE framework, i.e. what levels for the reference points perform best in terms of the sustainability and profitability indicators Read moreRead less