A Randomised Controlled Trial Of The Effect Of Hydrocortisone On Mortality In Critically Ill Patients With Septic Shock
Funder
National Health and Medical Research Council
Funding Amount
$3,432,452.00
Summary
This study performed across Australia and New Zealand will evaluate whether hydrocortisone, a cheap drug when administered to critically ill patients with severe infection, will save lives.
The Trans Tasman Radiation Oncology Group is an experienced research group conducting cancer clinical trials involving radiotherapy (RT) in order to improve cure rates, quality of life and to reduce side-effects of treatment. Fifty per cent of all cancer patients need RT as part of their treatment. The aim of the proposal is to strengthen the quality and safety of RT trials by (a) enabling rapid review and checking of treatment by electronic means and (b) improve trial design.
Generating The Evidence For New Strategies To Combat Cardiovascular Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$12,809,917.00
Summary
The Program brings together clinicians, epidemiologists and statisticians in a unique endeavour combating heart attack and stroke. For the foreseeable future, these conditions will remain leading causes of death and disease in Australia and the world. While there are many established treatment and prevention strategies there remains great potential for further advances to avert large numbers of deaths and serious disabling outcomes. This Program will provide new information that will give patien ....The Program brings together clinicians, epidemiologists and statisticians in a unique endeavour combating heart attack and stroke. For the foreseeable future, these conditions will remain leading causes of death and disease in Australia and the world. While there are many established treatment and prevention strategies there remains great potential for further advances to avert large numbers of deaths and serious disabling outcomes. This Program will provide new information that will give patients, doctors, consumers and policy makers new options for disease prevention.Read moreRead less
Low OxyGen Intervention For Cardiac Arrest Injury Limitation Trial (LOGICAL)
Funder
National Health and Medical Research Council
Funding Amount
$2,314,402.00
Summary
Life support with mechanical ventilation (MV) is required for most patients after cardiac arrest. Delivery of liberal oxygen therapy to patients receiving MV is standard care and exposes them to a high oxygen dose and higher blood oxygen levels. A higher amount of oxygen might be harmful after cardiac arrest, but the optimal oxygen therapy in these patients is uncertain. This study tests standard care versus a protective conservative dose of oxygen on neurological recovery after cardiac arrest.
Fluid resuscitation is widely used in the management of critically ill patients. There are a variety of different fluids available to doctors but there is little evidence regarding how effective they are. One of the most commonly used fluids, a hydroxyethyl starch was recently approved by the TGA for use in Australia. This project aims to compare how effective and safe this fluid is compared to another widely used fluid, saline, for resuscitation of critically ill patients in intensive care.
Integration Of Basic And Translational Genitourinary Cancer Research Into Academic Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$467,961.00
Summary
Improvements in human health can only occur when the best basic research is tested in the best clinical trials and then applied in clinical practice across the board. Practitioner Fellowships are designed to support people who bridge these areas. This Fellowship will support an integrated program of research involving laboratory studies in prostate cancer, clinical trials in prostate and other types of cancer, application to clinical practice, and high level clinical and research leadership.
Improving Research Evidence Quality Using Individual Patient Data, Prospective Meta-analysis And Trial Registration
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
The quality of evidence we use to make health care decisions can be improved if we use systematic reviews that are planned ahead, that use raw data from each participant and include all the trials that have looked at the clinical problem. This research program will utilise these three ways of obtaining better quality data and will thus make research results more reliable. In particular, we will use these techniques to address health problems in mothers and babies.
Optimising The Management Of Patients With Atrial Fibrillation - The Standard Vs Atrial Fibrillation SpEcific ManagemenT StudY (SAFETY)
Funder
National Health and Medical Research Council
Funding Amount
$65,040.00
Summary
To optimise the management of patients with AF, we will conduct an intervention clinical trial, the goal of which is to develop and implement a care program that aims to improve the health of patients with AF. This will be done by comparing the usual care that patients would normally receive in hospital and in the community with a specialised and individualised health care program - the Standard vs Atrial Fibrillation spEcific managemenT studY (SAFETY).
Central Venous Catheter-associated Bloodstream Infections In Patients With Cancer: A Prospective Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$88,218.00
Summary
Patients with cancer often require prolonged access to the bloodstream via a central venous access device in order to deliver chemotherapy treatments as well as associated supportive and symptomatic therapies. A common serious side-effect of having this device is the development of an infection in the blood. This research will investigate whether insertion of the device into the non-dominant side of the body will reduce the likelihood of developing a bloodstream infection.