Integration Of Basic And Translational Genitourinary Cancer Research Into Academic Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$467,961.00
Summary
Improvements in human health can only occur when the best basic research is tested in the best clinical trials and then applied in clinical practice across the board. Practitioner Fellowships are designed to support people who bridge these areas. This Fellowship will support an integrated program of research involving laboratory studies in prostate cancer, clinical trials in prostate and other types of cancer, application to clinical practice, and high level clinical and research leadership.
Many cancers shed small amounts of DNA (circulating tumour DNA or ctDNA) into the patient’s bloodstream. Recent technological advances now allow levels of ctDNA to be accurately measured in the blood. Changes in ctDNA levels have potential to be used as specific markers of disease progression and/or response to cancer therapy. This research will advance the use of ctDNA to serially follow patients and individualise treatment decisions in cancer management across several cancer types.
Improving The Lives Of Young People With Type 1 Diabetes Using State-of-the-Art Therapies
Funder
National Health and Medical Research Council
Funding Amount
$2,599,598.00
Summary
T1D profoundly affects the lives of an increasing number of young people and their families. H The proposed centre acknowledges these challenges and recognises the urgent need for a comprehensive and holistic approach involving a broad range of expertise, methodologies and collaboration. The centre will utilize clinical expertise of the CI’s, generating new knowledge for the successful development and use of technology in closed loop and semi-closed systems in young people with T1D.
The Role Of Expectation On Outcome In Patients With Musculoskeletal Disorders
Funder
National Health and Medical Research Council
Funding Amount
$388,334.00
Summary
What a patient expects from their health condition has an important influence on how well they do. These expectations are also thought to underpin placebo effects and several studies show that clinicians often make use of this in their daily practice. This research aims to explain how peoples' expectations influence the way they respond to different treatments. This information will help health professionals improve the the way they treat people with a range of different health problems.
The Victorian Centre For Applied Biostatistics (VCAB): Building Core Methodological Capacity For Population Health
Funder
National Health and Medical Research Council
Funding Amount
$2,497,184.00
Summary
Biostatistics is the scientific discipline that focusses on the methods used to design and analyse research studies on human health. Doctors and other researchers conduct increasingly complex studies to identify best approaches for the prevention and treatment of disease, and these studies must be underpinned by sound biostatistical methods. This Centre will develop a critical mass of expertise in this under-resourced area around a program of methodological research, translation and training.
Pathophysiology And Treatment Of Malaria In Our Region
Funder
National Health and Medical Research Council
Funding Amount
$951,005.00
Summary
Malaria continues to kill 420,000 people/year. I will lead a team of clinical scientists in identifying how each of the different malaria parasites cause damage to small blood vessels, kidneys and other organs, and will test whether two different drugs can improve these processes and reduce illness. Many of my previous research findings have changed malaria treatment in Australia and across SE Asia, and, where appropriate, I will use new research findings to improve treatments.
Improving Research Evidence Quality Using Individual Patient Data, Prospective Meta-analysis And Trial Registration
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
The quality of evidence we use to make health care decisions can be improved if we use systematic reviews that are planned ahead, that use raw data from each participant and include all the trials that have looked at the clinical problem. This research program will utilise these three ways of obtaining better quality data and will thus make research results more reliable. In particular, we will use these techniques to address health problems in mothers and babies.
Prof. Simes will lead and develop research at the NHMRC Clinical Trials Centre in collaboration with major national and international cooperative groups. Research themes include integrating molecular science with trial design and embedding research routinely in health care. Projects include surgery for rectal cancer; novel targeted therapy in gastric cancer; aspirin to prevent colon cancer; placental transfusion for preterm babies; risk in heart disease; economic assessment of clinical trials.