Ultra-sensitive 3D molecular assays using total body PET and deep learning. Recent advances in biomedical engineering have led to the development of Total Body Positron Emission Tomography (TB-PET), the most sensitive imaging device to date. Despite these impressive engineering advances, computational methods lag far behind and model-based approaches cannot deal with the complexity or volume of data these systems produce. We will develop new computational methods based on deep learning and stati ....Ultra-sensitive 3D molecular assays using total body PET and deep learning. Recent advances in biomedical engineering have led to the development of Total Body Positron Emission Tomography (TB-PET), the most sensitive imaging device to date. Despite these impressive engineering advances, computational methods lag far behind and model-based approaches cannot deal with the complexity or volume of data these systems produce. We will develop new computational methods based on deep learning and statistical methods that fully exploit the richness and complexity of the data generated by TB-PET, enabling 3D quantitative assays of molecular processes throughout the entire human body with unparalleled sensitivity. The technology we create will open up new capability for the study of complex physiological systems.Read moreRead less
Yours and mine: development of the concept of ownership in typical children and those on the autism spectrum. From an early age we know what belongs to us and what does not - we intend to find out how our behaviours keep pace with this evolving knowledge. More important for society, we will find out if behaviours and concepts are qualitatively different in children with Autistic Spectrum Disorders (ASD), causing problems with social interactions.
Investigating Linguistic Factors Associated with Stuttering in Cantonese. The aim of this research is to gain new knowledge about the cause of stuttering. The project is a collaboration between experts in stuttering in Australia and Hong Kong. Despite decades of study, the cause of stuttering is still not well understood. Research in English has suggested that changes in emphasis from syllable to syllable can trigger individual moments of stuttering. However, Cantonese is very different from Eng ....Investigating Linguistic Factors Associated with Stuttering in Cantonese. The aim of this research is to gain new knowledge about the cause of stuttering. The project is a collaboration between experts in stuttering in Australia and Hong Kong. Despite decades of study, the cause of stuttering is still not well understood. Research in English has suggested that changes in emphasis from syllable to syllable can trigger individual moments of stuttering. However, Cantonese is very different from English, being a tonal and syllabic language, and uncovering the linguistic triggers of stuttering in Cantonese will yield new insight into the complex causality of this disabling condition.Read moreRead less
Preventing hospital readmissions and loss of functional ability in high risk older adults: A randomised controlled trial. Older people have higher rates of hospital admission and readmission due to complications and falls. During hospitalisation, many older people experience functional decline which impacts on their future independence. Acute hospital services comprise the largest section of health expenditure in Australia, costing $26,413 million/year. Prevention or delay of disease is known to ....Preventing hospital readmissions and loss of functional ability in high risk older adults: A randomised controlled trial. Older people have higher rates of hospital admission and readmission due to complications and falls. During hospitalisation, many older people experience functional decline which impacts on their future independence. Acute hospital services comprise the largest section of health expenditure in Australia, costing $26,413 million/year. Prevention or delay of disease is known to produce more effective use of services. This study will compare the effectiveness of innovative strategies to prevent deconditioning, functional decline and hospital readmissions. Comparative analysis of these strategies will provide information with potential to reduce costs whilst improving functional status, psychosocial well-being and independence in older peopleRead moreRead less
Comprehensive discharge-planning and in-home follow-up for older adults incorporating exercise strategies to avoid de-conditioning and reduce risk of hospital re-admission. Older people have significantly higher rates of hospital admission and length of stay than the general population and higher rates of hospital re-admission due to complications and falls. During hospitalisation, older people experience significant functional decline which impacts on their future levels of independence and qua ....Comprehensive discharge-planning and in-home follow-up for older adults incorporating exercise strategies to avoid de-conditioning and reduce risk of hospital re-admission. Older people have significantly higher rates of hospital admission and length of stay than the general population and higher rates of hospital re-admission due to complications and falls. During hospitalisation, older people experience significant functional decline which impacts on their future levels of independence and quality of life. This research aims to design, deliver and evaluate an innovative model of discharge planning and in-home exercise-based follow-up for community-living frail older people at high risk of hospital re-admission as a means of promoting health. Results should delay occurrence of disease, reduce re-admissions, and improve functional status, psycho-social well-being and patient satisfaction.Read moreRead less
Memory and the temporal lobes. This project will use brain imaging techniques to investigate how humans perceive, combine and access stored knowledge about the world via different senses. This information will not only provide information on normal brain processes, but will also provide vital data on what happens to memory if certain regions of the brain become damaged.
An Integrative Theory of Flashback Memories. Flashback memories are a core phenomenon in a range of psychological disorders. People who have suffered trauma, for example, experience a sense of reliving the past. This project will conduct the first comprehensive analysis of flashbacks by building on existing theories of autobiographical memory and applying convergent methodologies to study flashbacks. The project will assess the content, retrieval mode, and the brain mechanisms underpinning fl ....An Integrative Theory of Flashback Memories. Flashback memories are a core phenomenon in a range of psychological disorders. People who have suffered trauma, for example, experience a sense of reliving the past. This project will conduct the first comprehensive analysis of flashbacks by building on existing theories of autobiographical memory and applying convergent methodologies to study flashbacks. The project will assess the content, retrieval mode, and the brain mechanisms underpinning flashbacks. These data will lead to the first empirically-driven model of flashbacks that encompasses the psychological and neural bases of flashbacks. This model will advance our understanding of cognitive processes underpinning many psychological disorders.Read moreRead less
The influence of parental alcohol expectancies on offsprings' alcohol expectancies and drinking: A longitudinal study. It has been shown that potentially modifiable alcohol related cognitions, such as alcohol expectancies (AE)and drinking refusal self-efficacy (DRSE) are formed in childhood are related to drinking in adolescents and adults. The question of how these beliefs are formed is still unanswered. This longitudinal study examines the influences of parental alcohol-related beliefs and ....The influence of parental alcohol expectancies on offsprings' alcohol expectancies and drinking: A longitudinal study. It has been shown that potentially modifiable alcohol related cognitions, such as alcohol expectancies (AE)and drinking refusal self-efficacy (DRSE) are formed in childhood are related to drinking in adolescents and adults. The question of how these beliefs are formed is still unanswered. This longitudinal study examines the influences of parental alcohol-related beliefs and drinking, on children's alcohol-related beliefs and drinking behaviour. Positive results of this study will improve primary prevention by identifying and changing modifiable variables for populations potentially at-risk of developing later alcohol-related. It will also help to reduce cost and suffering of a major problem in Ausstralia.
problems.
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Whether social media literacy mitigates effects of social media in adolescents. This project aims to determine protective and risk factors for problems associated with social media use in early adolescents. In particular, it aims to determine the protective role of social media literacy (the skill to analyse, critique and evaluate social media posts). Although most Australian adolescents use social media, frequent social media engagement and photo-based activities can cause body dissatisfaction, ....Whether social media literacy mitigates effects of social media in adolescents. This project aims to determine protective and risk factors for problems associated with social media use in early adolescents. In particular, it aims to determine the protective role of social media literacy (the skill to analyse, critique and evaluate social media posts). Although most Australian adolescents use social media, frequent social media engagement and photo-based activities can cause body dissatisfaction, disordered eating and compromised well-being. Findings supporting a protective role for social media literacy are expected to inform policy to improve adolescent well-being and pave the way for school-based social media literacy interventions.Read moreRead less
Cognitive control in obsessive-compulsive disorder. Obsessive-compulsive disorder is associated with significant social and economic burden. There is a pressing need to understand the cognitive mechanisms that drive and maintain this disorder. This research will permit exciting advances that will extend existing models of OCD by (1) elucidating the effects of different strategies for responding to obsessional thoughts,(2) integrating psychological, cognitive, and neuropsychological models of OCD ....Cognitive control in obsessive-compulsive disorder. Obsessive-compulsive disorder is associated with significant social and economic burden. There is a pressing need to understand the cognitive mechanisms that drive and maintain this disorder. This research will permit exciting advances that will extend existing models of OCD by (1) elucidating the effects of different strategies for responding to obsessional thoughts,(2) integrating psychological, cognitive, and neuropsychological models of OCD, (3) developing innovative approaches to intrusive thoughts that will benefit the treatment of OCD and (4) shaping the research directions of future Australian researchers. Read moreRead less