Visualising below the tip of the proteome iceberg. Proteomics attempts to understand human biology by examining the protein components of cells and tissues. Unfortunately, currently available technology only allows approximately 10% of the complexity of these cells and tissues to be concurrently investigated. This project will the physical, chemical and functional properties of protein classes for enrichment, as well as improve technologies for protein visualization, identification and character ....Visualising below the tip of the proteome iceberg. Proteomics attempts to understand human biology by examining the protein components of cells and tissues. Unfortunately, currently available technology only allows approximately 10% of the complexity of these cells and tissues to be concurrently investigated. This project will the physical, chemical and functional properties of protein classes for enrichment, as well as improve technologies for protein visualization, identification and characterization. These approaches will allow the scientific community to further mine beneath the surface of the proteomics 'iceberg'.Read moreRead less
Development of a risk assessment tool to minimise mixed metals toxicities from mine tailings. Research based on animal uptake from mine tailings is required to quantify comparative bioavailability of mixtures of metals to provide data for mine rehabilitation design during the planning stage. Such data also provides risk assessment in humans. The optimum balance is minimum environmental effects from the rehabilitated mine structure versus minimised cost through planning prior to project commencem ....Development of a risk assessment tool to minimise mixed metals toxicities from mine tailings. Research based on animal uptake from mine tailings is required to quantify comparative bioavailability of mixtures of metals to provide data for mine rehabilitation design during the planning stage. Such data also provides risk assessment in humans. The optimum balance is minimum environmental effects from the rehabilitated mine structure versus minimised cost through planning prior to project commencement. The significant cost of mining ore bodies, particularly by modern open cut methods, is the removal of rock and soil. The research on animal toxicity testings will provide a tool to more accurately detail mine rehabilitation and give quantitative indicators for closure.Read moreRead less
Promoting Child and Carer Wellbeing and Placement Stability in Kinship Care. Kinship care is the fastest growing out-of-home care placement in Australia, yet least supported. This project aims to implement and evaluate an attachment and trauma-based program for kinship carers, explore its suitability for cultural adaptation for Indigenous families and co-design practical resources to promote program sustainability and trauma-informed practice. This project is Australia’s first randomised trial o ....Promoting Child and Carer Wellbeing and Placement Stability in Kinship Care. Kinship care is the fastest growing out-of-home care placement in Australia, yet least supported. This project aims to implement and evaluate an attachment and trauma-based program for kinship carers, explore its suitability for cultural adaptation for Indigenous families and co-design practical resources to promote program sustainability and trauma-informed practice. This project is Australia’s first randomised trial of a tailored program for kinship carers and expects to generate vital knowledge on evidence-based support. Via implementing an innovative program for kinship carers in statutory child protection, this project should build capacity for research-based practice and benefit family wellbeing and placement outcomes in kinship care.Read moreRead less
Does emotion regulation flexibility improve functioning in refugees? This project aims identify the mechanisms by which low-intensity interventions improve functioning in refugees living in low-and-middle income countries (LMICs). Despite these interventions being implemented with thousands of refugees worldwide, many refugees fail to respond. This project will lead to significant advances in knowledge regarding how and for whom low intensity interventions work. Expected outcomes include enhance ....Does emotion regulation flexibility improve functioning in refugees? This project aims identify the mechanisms by which low-intensity interventions improve functioning in refugees living in low-and-middle income countries (LMICs). Despite these interventions being implemented with thousands of refugees worldwide, many refugees fail to respond. This project will lead to significant advances in knowledge regarding how and for whom low intensity interventions work. Expected outcomes include enhanced capacity of NGOs to deliver effective interventions to refugees living in LMICs, and to tailor their services to those who are at greatest risk of not responding. Benefits include improved functioning of refugees living in LMICs, and enhanced capacity of Australia to meet its international refugee obligations. Read moreRead less
Translation of evidence into pain management practices in acute care environments. This project addresses the urgent need to reduce the substantial pain experienced by patients following surgery by improving the clinical processes associated with the treatment of pain. Each year in Australia, six million people are admitted to hospital for surgery. A recent review of Australian research has shown that up to 40% of hospitalised surgical patients experience significant pain. Despite the availabili ....Translation of evidence into pain management practices in acute care environments. This project addresses the urgent need to reduce the substantial pain experienced by patients following surgery by improving the clinical processes associated with the treatment of pain. Each year in Australia, six million people are admitted to hospital for surgery. A recent review of Australian research has shown that up to 40% of hospitalised surgical patients experience significant pain. Despite the availability of effective treatment, pain after surgery is often under-treated and is one of the main postoperative adverse outcomes. A consequence of poor pain management is that patients experience unnecessary suffering, higher incidence of postoperative complications significant risk of developing chronic post-surgical pain.Read moreRead less
Tonal language development in Mandarin and Cantonese-speaking children with cochlear implants. Cochlear implantation in children is expanding in countries where tonal languages are spoken, despite limited evidence of the effectiveness of implant use in these settings. This project will examine the impact of implant use on children's perception of tone, their production of speech and assesses how this affects functional communication.
Examination of the cognitive and biological circuitry underlying social-cognitive training in first episode psychosis. There is a national need to develop more effective interventions that improve the social lives of those with psychotic disorders. This project identifies key markers underlying the benefits of social-cognition training. These outcomes will establish a theoretical and practical framework of critical markers that can be used to improve social outcomes.
Factors influencing functional locomotion in older adults. Ageing is associated with increasing limitations of physical function such as walking. Many older people also have concurrent medical conditions which may further limit function. This project adopts a multidisciplinary approach to investigate key factors that affect the ability to perform functional tasks of everyday locomotion, such as stair climbing and obstacle avoidance, in older adults including those affected by osteoarthritis. The ....Factors influencing functional locomotion in older adults. Ageing is associated with increasing limitations of physical function such as walking. Many older people also have concurrent medical conditions which may further limit function. This project adopts a multidisciplinary approach to investigate key factors that affect the ability to perform functional tasks of everyday locomotion, such as stair climbing and obstacle avoidance, in older adults including those affected by osteoarthritis. The results will increase knowledge about the adaptability of the ageing human locomotor system in both health and disease. This will provide a theoretical foundation for creating new strategies to reduce the impact of physical degeneration in older people.Read moreRead less
Suicide prevention and management of deliberate self-harm: randomised control trial of an assertive engagement, brief psychotherapy and community linkage model. Suicide is the second commonest cause of death by injury in Australia. Suicide prevention is an important public health priority but rates remain high. People who have previously attempted suicide are most likely to kill themselves. Most suicidal people attend emergency departments where they get inadequate treatment for their psychologi ....Suicide prevention and management of deliberate self-harm: randomised control trial of an assertive engagement, brief psychotherapy and community linkage model. Suicide is the second commonest cause of death by injury in Australia. Suicide prevention is an important public health priority but rates remain high. People who have previously attempted suicide are most likely to kill themselves. Most suicidal people attend emergency departments where they get inadequate treatment for their psychological and social problems and remain depressed and suicidal. This project will test the effectiveness of a new psychological and social treatment to reduce the depression and link suicidal people with community supports. If successful, this treatment could be provided in any emergency department and help decrease suicide rates in Australia.Read moreRead less
Evaluating the feasibility and effect of using a hospital wide coordinated approach to introduce evidence-based changes for pain management. This project will develop a comprehensive educational program and approach to pain management for public and private hospitals that could be used by other hospitals elsewhere. An educational program for hospitals staff, and specifically for Pain Resource Nurses, will be produced. This project has the potential to minimise the experience of pain and prevent ....Evaluating the feasibility and effect of using a hospital wide coordinated approach to introduce evidence-based changes for pain management. This project will develop a comprehensive educational program and approach to pain management for public and private hospitals that could be used by other hospitals elsewhere. An educational program for hospitals staff, and specifically for Pain Resource Nurses, will be produced. This project has the potential to minimise the experience of pain and prevent widespread complications associated with pain for all hospitalised patients, irrespective of diagnosis or reason for admission. It is also envisaged that this project will establish a model of change that could be used to facilitate evidence-based practice in other aspects of healthcare apart from pain.Read moreRead less