Computational techniques for protease research. Protease research is an area of intensive research in Australia. Correctly assessing the mechanisms of protease function is crucial not only for improving our health through medical research and drug development, but also to multiple national areas of research and development, including biotechnology, agriculture, and industries such as the dairy industry. This project will develop innovative computational techniques to advance understanding of h ....Computational techniques for protease research. Protease research is an area of intensive research in Australia. Correctly assessing the mechanisms of protease function is crucial not only for improving our health through medical research and drug development, but also to multiple national areas of research and development, including biotechnology, agriculture, and industries such as the dairy industry. This project will develop innovative computational techniques to advance understanding of how proteases function by redressing a common research assumption that can significantly affect the accuracy of protease function prediction. The outcomes will improve fundamental research into proteases, and enable improved research and development in the many fields that rely on protease work.Read moreRead less
Special Research Initiatives - Grant ID: SR0563610
Funder
Australian Research Council
Funding Amount
$111,115.00
Summary
Developing an E-Platform for Application of Clinical Management in the Human Respiratory and Vascular System. This project aims to develop an E-PLATFORM that will provide a simulation-based virtual reality environment for clinical management and therapy treatment in the human respiratory and vascular system. One significant feature of the expected outcomes is the ability for surgeon or physician to adequately plan their treatment or operation decision-making of respiratory or vascular disease, i ....Developing an E-Platform for Application of Clinical Management in the Human Respiratory and Vascular System. This project aims to develop an E-PLATFORM that will provide a simulation-based virtual reality environment for clinical management and therapy treatment in the human respiratory and vascular system. One significant feature of the expected outcomes is the ability for surgeon or physician to adequately plan their treatment or operation decision-making of respiratory or vascular disease, in particular, from the point of view of flow analysis using state-of-the-art computational fluid dynamics techniques. This research proposal aims to facilitate new medical research and development for treatment of respiratory and/or vascular diseases, which can have a great socioeconomic benefit to the Australian community.Read moreRead less
Personalised Learning for Per-pixel Prediction Tasks in Image Analysis. AI-assisted image segmentation & synthesis are very challenging and usually require pixel-level labelling (per-pixel prediction) that is costly to obtain. The small amount of labels makes it difficult to train an “optimal” unified model for varied data as conventional methods did. This project aims to develop a new paradigm “personalised learning” to tackle this problem, where each image could be dealt with a model tailored ....Personalised Learning for Per-pixel Prediction Tasks in Image Analysis. AI-assisted image segmentation & synthesis are very challenging and usually require pixel-level labelling (per-pixel prediction) that is costly to obtain. The small amount of labels makes it difficult to train an “optimal” unified model for varied data as conventional methods did. This project aims to develop a new paradigm “personalised learning” to tackle this problem, where each image could be dealt with a model tailored to individual characteristics. The success of this project could significantly advance the fundamental research in image analysis. Expected outcomes include new knowledge and algorithms for image analysis, which could benefit fields like biology and archaeology, where labeled images are hard to attain and scarce.Read moreRead less
An integrated virtual functional human body (VFHB). This research is aimed at extracting and harnessing new knowledge from the immense volume of biomedical imaging data that is currently generated in healthcare through innovative information technologies. These technologies will allow a ‘virtual functional human body’ in a realistic, comprehensible visual format to be built, which will be accessible to researchers and lay individuals. It is expected that it will lead to a paradigm-change in the ....An integrated virtual functional human body (VFHB). This research is aimed at extracting and harnessing new knowledge from the immense volume of biomedical imaging data that is currently generated in healthcare through innovative information technologies. These technologies will allow a ‘virtual functional human body’ in a realistic, comprehensible visual format to be built, which will be accessible to researchers and lay individuals. It is expected that it will lead to a paradigm-change in the delivery of information systems, scientific discovery and impact on a lay individual's perception of their health status such that it will empower them to actively participate in their health and general well-being.Read moreRead less
Multi-modal, Multi-dimensional Virtual Microscopy for Diagnostic Quantitative Pathology. This project will contribute to the development of a new generation of virtual microscopy (VM) systems that provide new and innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of pathology. These systems have the potential to significantly enhance the efficiency and efficacy of not only primary diagnostic workflows, but also aspects of profi ....Multi-modal, Multi-dimensional Virtual Microscopy for Diagnostic Quantitative Pathology. This project will contribute to the development of a new generation of virtual microscopy (VM) systems that provide new and innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of pathology. These systems have the potential to significantly enhance the efficiency and efficacy of not only primary diagnostic workflows, but also aspects of proficiency testing and continuing education vital for a vibrant, well regulated discipline. In addition, the project will contribute to our knowledge of the pathology assessed in the screening and diagnosis of cancers such as cervical, lung and bladder cancers.Read moreRead less
Biomedical Visual Image Analytics for Multi-disciplinary Retrieval. The project aims to develop a framework to provide users with the interactive access to information that is necessary for the best collaborative decision-making. Visual analytics theory is becoming increasing valuable for managing ‘big data’ because it can provide interactive and intuitive understanding of the rich information embedded within complex data and decision support systems. There are, however, fundamental challenges t ....Biomedical Visual Image Analytics for Multi-disciplinary Retrieval. The project aims to develop a framework to provide users with the interactive access to information that is necessary for the best collaborative decision-making. Visual analytics theory is becoming increasing valuable for managing ‘big data’ because it can provide interactive and intuitive understanding of the rich information embedded within complex data and decision support systems. There are, however, fundamental challenges that currently prevent visual analytics from being routinely applied to multi-disciplinary collaboration, which is now ‘the norm’ to solve large complicated problems where there is significant social impact. This project aims to address these challenges and improve visual analytics theory by developing a biomedical visual image analytics framework that enables interactive information retrieval of multidisciplinary databases.Read moreRead less
Thinking Systems: Navigating Through Real and Conceptual Spaces. The project will provide fundamental insights into physical and conceptual spaces and develop applications in robotics and information systems. The project brings together national and international researchers to study how humans and other animals navigate: how trajectories through space are used to build maps, the neural bases of these mapping processes and how to use maps to achieve goals. The project will develop a new generati ....Thinking Systems: Navigating Through Real and Conceptual Spaces. The project will provide fundamental insights into physical and conceptual spaces and develop applications in robotics and information systems. The project brings together national and international researchers to study how humans and other animals navigate: how trajectories through space are used to build maps, the neural bases of these mapping processes and how to use maps to achieve goals. The project will develop a new generation of robots that can learn about the physical spaces they work in, and create concept-mapping systems that can map and navigate information spaces. Also, it will provide new insights into the mechanisms regulating human cognition and mental dysfunctions.Read moreRead less
Nonlinear Dynamics of Pulse Coupled Oscillators. A mathematical model of the heart pacemaker system will be created, based on simple interacting units. These units have been shown to be good models of physiological information e.g. the discrimination of different influences on heart rate. We will firstly look at the interaction of the units in simple combinations and then tune the model to mimic the behaviour of the cardiac pacemaker.
Potential benefits may arise from elucidating the mechanis ....Nonlinear Dynamics of Pulse Coupled Oscillators. A mathematical model of the heart pacemaker system will be created, based on simple interacting units. These units have been shown to be good models of physiological information e.g. the discrimination of different influences on heart rate. We will firstly look at the interaction of the units in simple combinations and then tune the model to mimic the behaviour of the cardiac pacemaker.
Potential benefits may arise from elucidating the mechanisms underlying arrhythmias which contribute to ?sudden cardiac death? in young men, and suggesting strategies for artificial pacemakers to effectively arrest abnormal rhythms before they convert to potentially fatal fibrillation.Read moreRead less
Multiscale integration of imaging and omics data. This project aims to integrate multiscale imaging and molecular data to characterise disease in patients. Modern healthcare needs to embrace ‘big (health) data’s potential to address an ageing population’s increasing healthcare demands and the inefficiencies and waste in patient treatment. This project expects to pioneer basic science research in methodologies to integrate, correlate and then derive knowledge from multi-scale data, to characteris ....Multiscale integration of imaging and omics data. This project aims to integrate multiscale imaging and molecular data to characterise disease in patients. Modern healthcare needs to embrace ‘big (health) data’s potential to address an ageing population’s increasing healthcare demands and the inefficiencies and waste in patient treatment. This project expects to pioneer basic science research in methodologies to integrate, correlate and then derive knowledge from multi-scale data, to characterise the mechanisms of disease in individual patients, in space and time. Its integrated model is expected to form the basis of a framework for individualised patient disease analysis.Read moreRead less
Application of manifold-based image analysis to identify subtle changes in digitally-captured pathology samples. This project will research and develop advanced computer aided analytics for digital pathology with the aim of automating several common pathology tests. This project should not only greatly increase the speed of pathology tests but should also improve quality, lower costs and improve patient outcomes.