Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100177
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A flexible high throughput analytical system for psychopharmacology and drug discovery. A sensitive new liquid chromatography mass spectrometer will enable a team of leading researchers to detect drugs of abuse and therapeutic drugs in the brain and body as well as levels of hormones, peptides and neurotransmitters. This will enhance a large number of projects examining new treatments for addictive disorders and mental illness.
Enhancing outcomes for separated families by improving family mediation. More than 100,000 adults and 60,000 children experience family breakdown each year in Australia, which wreaks enormous personal, social, and economic costs. This project aims to develop more effective ways to mediate disputes over shared parenting after family breakdown.
The role of threat expectancy and attentional bias modification in promoting attentional capture and disengagement in acute experimental pain. This study will test the effectiveness of a number of variants of a promising new treatment in changing responses to an experimental pain task, the cold pressor. The aim is to develop a novel treatment, with preliminary evidence for its efficacy, that can be tested as a treatment for the prevention and treatment of chronic pain.
RCTs on Trial: How Placebo Effects Could Undermine Double-blind RCTs. Double-blind randomised placebo-controlled trials (RCTs) are considered the gold standard for establishing treatment efficacy. However, there are both theoretical and empirical reasons to believe that they do not adequately control for the placebo effect. Cost and ethical considerations prevent researchers conducting actual double-blind RCTs with patients from exploring these issues. To address this gap, this project uses nove ....RCTs on Trial: How Placebo Effects Could Undermine Double-blind RCTs. Double-blind randomised placebo-controlled trials (RCTs) are considered the gold standard for establishing treatment efficacy. However, there are both theoretical and empirical reasons to believe that they do not adequately control for the placebo effect. Cost and ethical considerations prevent researchers conducting actual double-blind RCTs with patients from exploring these issues. To address this gap, this project uses novel experimental models to systematically test key aspects of the double-blind RCT methodology that are intended to control for the placebo effect. The project aims to provide essential data on the validity of these trials, thereby improving Australia's health and ensuring that Government treatment subsidies are well spent.Read moreRead less
Building economic development through psychosocial intervention. This project is the first study that reduces poverty and increases productivity in a post-conflict country by addressing the psychosocial problems that impede the capacity of a workforce to effectively learn and apply skills. Although conducted in Aceh, Indonesia, these findings may show how to reduce poverty in all countries affected by conflict.
Relative efficacy of self-help treatment for insomnia. This project aims to improve available non-pharmacological treatments for insomnia by determining the relative efficacy of various forms of self-help treatment compared to standard, therapist-led, treatment. Sleep disorders have serious consequences and are widespread. Drug therapies are costly and ineffective and, while psychological treatments have a well-established evidence base, they are not utilised by many. Self-help is a potential ....Relative efficacy of self-help treatment for insomnia. This project aims to improve available non-pharmacological treatments for insomnia by determining the relative efficacy of various forms of self-help treatment compared to standard, therapist-led, treatment. Sleep disorders have serious consequences and are widespread. Drug therapies are costly and ineffective and, while psychological treatments have a well-established evidence base, they are not utilised by many. Self-help is a potential solution, but has not been properly evaluated. This project will determine the efficacy of self-help, the best delivery methods, and should result in more individuals with sleep problems receiving better and cheaper help with benefits for them and society in general.Read moreRead less
The regulation of desire by bodily state. Many experiences, like food, wine and sex, are pleasurable. These experiences are also desired, but less so when sated. The aim of this proposal is to understand how satiation regulates desire. We propose two memory-based models, and test them using several new experimental approaches. This is significant, not only because poorly regulated desire is linked to many social and economic ills (e.g., over-eating), but also because it is a key part of huma ....The regulation of desire by bodily state. Many experiences, like food, wine and sex, are pleasurable. These experiences are also desired, but less so when sated. The aim of this proposal is to understand how satiation regulates desire. We propose two memory-based models, and test them using several new experimental approaches. This is significant, not only because poorly regulated desire is linked to many social and economic ills (e.g., over-eating), but also because it is a key part of human motivation that is poorly understood. The expected outcome is a new theoretical model of how memory processes interact with bodily signals to generate both sated states and desire. The benefits include a new understanding of how desire is regulated and how and why this might break down.Read moreRead less
Integrated depression management: a trial of a new model of care in a low vision rehabilitation setting. The project will integrate depression management into Vision Australia services and evaluate the impact of this new model of care. We anticipate that this new approach will lead to sustained improvements in clients’ quality of life.
Modelling dynamic interactive social processes. This project aims to enhance our understanding of complex social systems by developing empirically testable mathematical models for interactive, dynamic social processes. Models will be developed for such processes as the development of interpersonal and inter-organisational networks, and social influence and diffusion. They will be assessed using new and exacting evaluation techniques. The results will strengthen the mathematical foundation for ....Modelling dynamic interactive social processes. This project aims to enhance our understanding of complex social systems by developing empirically testable mathematical models for interactive, dynamic social processes. Models will be developed for such processes as the development of interpersonal and inter-organisational networks, and social influence and diffusion. They will be assessed using new and exacting evaluation techniques. The results will strengthen the mathematical foundation for modelling in the social sciences, and will have immediate application in several diverse domains, including: the structure of networks relevant to disease transmission; the social epidemiology of rural mental health; and the emergence of collective structures in organisations.Read moreRead less
Modeling cross-level interactions in complex networked social systems. The advances of this collaboration will add significantly to Australian and international capacity in the modelling of complex social systems. The outcomes will be directly translated, through these and other collaborations, into practical scientific outcomes in several significant policy areas. There is widespread demand for these modelling techniques in empirical settings. Potential applications from ongoing national collab ....Modeling cross-level interactions in complex networked social systems. The advances of this collaboration will add significantly to Australian and international capacity in the modelling of complex social systems. The outcomes will be directly translated, through these and other collaborations, into practical scientific outcomes in several significant policy areas. There is widespread demand for these modelling techniques in empirical settings. Potential applications from ongoing national collaborations include: Hepatitis C spread through sexual and needle sharing networks; labour market dynamics; mental health and social support in rural communities; defence applications; and environmental governance. A major emphasis is the training of postgraduates in the application of complex modelling techniques.Read moreRead less