A Multi Centre, Randomised, Blinded, Placebo Controlled Trial Comparing Intravenous Hydrocortisone With Placebo In Critically Ill Patients With Septic Shock.
Funder
National Health and Medical Research Council
Funding Amount
$317,997.00
Summary
This study performed across Australia and New Zealand will evaluate whether hydrocortisone, a cheap drug when administered to critically ill patients with severe infection, will save lives.
Targeted LOWering Of Central Blood Pressure In Patients With Hypertension: A Randomised Controlled Trial (LOW CBP Study)
Funder
National Health and Medical Research Council
Funding Amount
$1,442,405.00
Summary
For over 100 years doctors have measured blood pressure (BP) using a cuff at the upper arm. However, this method has many drawbacks that can result in inappropriate treatment decisions. New technology has emerged to measure central BP, which allows a more accurate BP assessment and may improve patient care. This study will test the clinical value of this new measure of central BP. Findings are expected to lead to a change in the way that people with high BP are diagnosed and managed by doctors.
Stereotactic Body Radiotherapy (SBRT) As A New Standard Of Care For Spinal Metastases
Funder
National Health and Medical Research Council
Funding Amount
$200,148.00
Summary
Secondary spread of cancer to the spine affects about 40% of all cancer patients. The current standard of care, radiotherapy, does not provide durable control of cancer pain. Breakthrough technology in stereotactic body radiotherapy (SBRT) is showing considerable promise for improved patient outcomes. This study is a multi-national collaboration between Australia and Canada directly comparing conventional radiotherapy to spinal SBRT in order to establish spinal SBRT as the new standard of care.
Physical Activity For Young People With Depression: A Cluster Randomised Controlled Trial To Test The Effectiveness Of Incorporating A Brief Intervention Into Routine Clinical Care
Funder
National Health and Medical Research Council
Funding Amount
$1,678,739.00
Summary
Depression and physical activity in young people are linked: lack of physical activity is a risk-factor for depression and physical activity can improve symptoms of depression. Physical activity is not routinely provided as an intervention, despite its potential to improve immediate treatment outcomes and prevent poor physical health. This study will evaluate an intervention that aims to include a brief physical activity intervention in routine clinical care for young people with depression.
Evaluation Of The Obesity Paradox In Diabetes: A Longitudinal Case-Control Study Of Half A Million Patients
Funder
National Health and Medical Research Council
Funding Amount
$344,721.00
Summary
Obesity is a risk factor for developing diabetes. However, recent studies reported increased mortality risk associated with normal body weight in people with incident diabetes compared to overweight or obese patients. This “obesity paradox”, where being overweight appears to be protective, is new in diabetes. The mechanism behind this is not known. Using 20 years of follow-up data on 500,000 diabetes and control patients, this study proposes to find possible explanations behind obesity paradox.
The SHARP-ER Study: Extended Follow-up Of The SHARP Study Cohort
Funder
National Health and Medical Research Council
Funding Amount
$1,106,265.00
Summary
The SHARP study, conducted from 2003 to 2010, recruited over 9,000 participants with kidney disease and showed, for the first time, that cholesterol-lowering was effective in preventing heart and vascular disease in people with advanced kidney disease. This study will extend follow-up to answers critical questions regarding long-term cardiovascular, renal and other health outcomes.
Increasing The Use Of Long-acting Reversible Contraception: The Australian Contraceptive ChOice PRoject (ACCORd)
Funder
National Health and Medical Research Council
Funding Amount
$726,144.00
Summary
Of all reversible contraceptive methods, long-acting reversible contraceptives (LARCs), such as intrauterine devices and hormone implants, are by far the most highly effective at preventing pregnancy. However, the prescription and use of LARCs amongst Australian women who are at risk of pregnancy is very low. To increase the uptake of LARCs, our study will trial a complex intervention that involves providing counselling to women and developing rapid referral pathways to LARC insertion.
Enabling Personalised Cohort Studies From Large Repositories Of Clinical Practice Data
Funder
National Health and Medical Research Council
Funding Amount
$520,968.00
Summary
We propose to leverage the information contained in large, routinely collected health datasets, by enabling personalised cohort studies on demand. Findings from these studies can be used to crowdsource prioritisation of clinical questions in need of further evidence. They can also provide an avenue to discuss and support treatment recommendations at the point-of-care.
Coping-Together: A Randomised Controlled Trial Of A Self-directed Coping Skills Intervention For Patients With Cancer And Their Partners
Funder
National Health and Medical Research Council
Funding Amount
$933,145.00
Summary
Although a cancer diagnosis and treatment have profound effects on both patients and their partners, most supportive care interventions target patients, whilst neglecting partners. To address this gap, our team is developing a Coping-Together intervention, which includes a novel, self-directed coping skills training workbook to assist couples affected by cancer manage common challenges post-diagnosis. This study will examine the efficacy of the Coping-Together intervention in decreasing couples’ ....Although a cancer diagnosis and treatment have profound effects on both patients and their partners, most supportive care interventions target patients, whilst neglecting partners. To address this gap, our team is developing a Coping-Together intervention, which includes a novel, self-directed coping skills training workbook to assist couples affected by cancer manage common challenges post-diagnosis. This study will examine the efficacy of the Coping-Together intervention in decreasing couples’ anxiety at 2, 5, 9, and 12 months post-baseline.Read moreRead less
A Randomised Controlled Trial Of The Effect Of Hydrocortisone On Mortality In Critically Ill Patients With Septic Shock
Funder
National Health and Medical Research Council
Funding Amount
$3,432,452.00
Summary
This study performed across Australia and New Zealand will evaluate whether hydrocortisone, a cheap drug when administered to critically ill patients with severe infection, will save lives.