Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal ....Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal invasiveness and perturbation are likely to transform ex-vivo cellular processes. The intended outcomes are crucial for maximising precision in engineering and implementing of ex-vivo cellular processes. Fundamental advances in knowledge may eventually be a platform for developing cell-based therapies.
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Understanding genetic and environmental risks of emotional disorders in childhood and adolescence. To reduce the burden of mental health disorders in Australia, this project will advance knowledge on genetic and environmental causes of anxiety and related disorders in children and adolescents. The results will allow better identification of children at risk for emotional problems and will identify new ways of tailoring prevention and treatment.
The neural basis of memory. Although they define us, our knowledge about how, and where, memories are processed and stored within the brain is still in its infancy. This project aims to investigate the morphological and functional changes that occur in cortical neurons during memory formation. By recording from both mouse and human neurons, this study will bridge the gap in knowledge between the heavily-investigated rodent brain and the human brain and advance our knowledge on how remote memorie ....The neural basis of memory. Although they define us, our knowledge about how, and where, memories are processed and stored within the brain is still in its infancy. This project aims to investigate the morphological and functional changes that occur in cortical neurons during memory formation. By recording from both mouse and human neurons, this study will bridge the gap in knowledge between the heavily-investigated rodent brain and the human brain and advance our knowledge on how remote memories are formed in individual neurons within the frontal cortex of the brain. These findings will highlight potential neural mechanisms that might be awry in cases of memory loss and amnesia.Read moreRead less
Next-generation methods for transport in poroelastic media with interfaces. Deformable porous structures are ubiquitous in the design of materials such as filters, sponges, and prosthetics. They often show complex mechano-chemical processes that occur across several spatio-temporal scales. To mathematically describe them requires coupled sets of nonlinear, multiphysical, and multiscale equations. This makes the design of accurate, efficient numerical methods challenging. The Fellowship aims to a ....Next-generation methods for transport in poroelastic media with interfaces. Deformable porous structures are ubiquitous in the design of materials such as filters, sponges, and prosthetics. They often show complex mechano-chemical processes that occur across several spatio-temporal scales. To mathematically describe them requires coupled sets of nonlinear, multiphysical, and multiscale equations. This makes the design of accurate, efficient numerical methods challenging. The Fellowship aims to address the mathematical characteristics encountered in poromechanics equations and their discretisation methods, and to devise novel mathematical and computational techniques for extending the analysis to cases where large deformations and the presence of interfaces and coupling with other neighbouring elements are relevant.Read moreRead less
Changing the lives of young Australians with emotional disorders using a simple three-step treatment based on cognitive-neuroscience insights. Anxiety and depression are emotional disorders that affect many Australian children and place them at risk of lifelong impairment. The latest evidence from cognitive science and neuroscience shows that these children have maladaptive thinking strategies that lead to avoidance and withdrawal. Capitalising on these basic science insights, this project exami ....Changing the lives of young Australians with emotional disorders using a simple three-step treatment based on cognitive-neuroscience insights. Anxiety and depression are emotional disorders that affect many Australian children and place them at risk of lifelong impairment. The latest evidence from cognitive science and neuroscience shows that these children have maladaptive thinking strategies that lead to avoidance and withdrawal. Capitalising on these basic science insights, this project examines a new treatment, referred to as the 'Emotional Flexibility Program', that targets childhood distress in three simple steps over just four weeks of treatment. This treatment could change the way childhood emotional disorders are treated and prevented, improve the quality of life for thousands of young Australians, and offset the associated economic burden of disease.Read moreRead less
Coupling biophotonic modalities with machine based recognition systems for disease diagnosis. This project will develop new ways to diagnose canine cancer, malaria and atherosclerosis using infrared-based technology and sophisticated pattern recognition techniques in the hope to discover infrared biomarkers that will lead to early diagnosis of the disease and ultimately save lives.
Defining the molecular and cellular mechanisms of beta cell dysfunction. This project will investigate the influence of environment in the functional adaptation and maladaptation of pancreatic beta cells in diabetes. The research will define the molecular and cellular mechanisms linking environmental triggers such as obesity, high fatty acid levels and hyperglycaemia to beta cell dedifferentiation and dysfunction.
Improving workplace productivity via an AI-based physical activity chatbot . This project aims to develop, train and evaluate a physical activity chatbot using artificial intelligence and machine learning to improve workplace productivity in sedentary office workers. Productivity losses, due to high numbers of physically inactive workers, cost the Australian economy $14 billion per year. The cost of effective and scalable workplace physical activity programs acts as a barrier to their implementa ....Improving workplace productivity via an AI-based physical activity chatbot . This project aims to develop, train and evaluate a physical activity chatbot using artificial intelligence and machine learning to improve workplace productivity in sedentary office workers. Productivity losses, due to high numbers of physically inactive workers, cost the Australian economy $14 billion per year. The cost of effective and scalable workplace physical activity programs acts as a barrier to their implementation. As such, innovative programs that can reach large numbers of workers at minimal cost are needed. This project aims to generate new knowledge on the use of artificial intelligence to achieve behavioural improvements and will lead to the development of a new type of behaviour change program with broad applicability.
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Mapping, recovery and remediation of arm coordination deficits after stroke. Coordination of arm movement is a significant problem after a stroke. This innovative project will underpin new treatments by focusing on what type of stroke causes difficulty in coordinating arm movement, describing the coordination difficulties in detail and investigating mechanisms of recovery and treatment.
Interpreting intrusions: Illuminating the cognitive mechanisms that fuel obsessional thought. This project aims to evaluate a theoretical model regarding the causal and maintaining role that cognitive biases play in obsessional thought. Obsessions are common in the general population and negatively impact health and daily functioning. Individuals struggle with their obsessions but are unable to disengage from them. A pressing question is: what makes an obsession so “sticky”? To answer this quest ....Interpreting intrusions: Illuminating the cognitive mechanisms that fuel obsessional thought. This project aims to evaluate a theoretical model regarding the causal and maintaining role that cognitive biases play in obsessional thought. Obsessions are common in the general population and negatively impact health and daily functioning. Individuals struggle with their obsessions but are unable to disengage from them. A pressing question is: what makes an obsession so “sticky”? To answer this question, this project aims to employ a novel, computerised experimental methodology to directly manipulate cognitive processes proposed to underpin obsessions. This methodology will be used to alter key biases proposed to drive obsessional thinking, thus shedding light on core psychological mechanisms.Read moreRead less