Many new therapies are being developed to treat stroke and prevent its recurrence. While a number of these have been successfully introduced, there is a puzzling gap between evidence of efficacy in animal models and humans. One of the main reasons may be lack of an integrated approach between the basic sciences and clinical researchers. By assembling a team with skills in both areas and a structure to maximise communication between groups this team plan to incrementally introduce new therapies i ....Many new therapies are being developed to treat stroke and prevent its recurrence. While a number of these have been successfully introduced, there is a puzzling gap between evidence of efficacy in animal models and humans. One of the main reasons may be lack of an integrated approach between the basic sciences and clinical researchers. By assembling a team with skills in both areas and a structure to maximise communication between groups this team plan to incrementally introduce new therapies into clinical practice.Read moreRead less
PRE CLINICAL TRIAL WITH FETAL PIG INSULIN-PRODUCING CELLS
Funder
National Health and Medical Research Council
Funding Amount
$292,416.00
Summary
If fetal pig cells are to be of value in normalizing blood glucose levels in diabetic people once transplanted, they must survive and mature after being grafted. The pre-clinical study proposed will examine several novel issues that are of direct relevance to future clinical trials. The diabetic pig will be used as recipient to address when the fetal cell matures after it is transplanted, how long the grafted cells will maintain normal blood glucose levels, and at which site it is most appropria ....If fetal pig cells are to be of value in normalizing blood glucose levels in diabetic people once transplanted, they must survive and mature after being grafted. The pre-clinical study proposed will examine several novel issues that are of direct relevance to future clinical trials. The diabetic pig will be used as recipient to address when the fetal cell matures after it is transplanted, how long the grafted cells will maintain normal blood glucose levels, and at which site it is most appropriate to transplant the cells. The baboon will be used as recipient to address the safety of transplanting the pig cells, especially from the pig endogenous retrovirus, and whether the immunosuppressive regime proposed for use in humans will prevent cellular rejection. The diabetic baboon will be used in the final experiment step to determine if normalization of blood glucose levels can be achieved in this xenografted animal just as it can in the diabetic pig.Read moreRead less
I am a rheumatologist and epidemiologist who concentrates on epidemiological studies understanding the causes and treatment of osteoarthritis and osteoporosis.
Improving The Management Of Nausea In Advanced Cancer: Pragmatic Tool For Assessing& Treating Nausea In Clincial Practi
Funder
National Health and Medical Research Council
Funding Amount
$100,000.00
Summary
Nausea and vomiting are common problems in-patients with advanced cancer and they are under-treated. The investigators will develop evidence-based tools to assist non-specialist clinicians in the assessment and treatment of nausea in advanced cancer. They will also develop an educational intervention to train health professionals to use these tools and pilot a randomised trial designed to evaluate the package in NSW and WA.
Protocol Development, Web-based Data Collection And Data Quality For All Cancer Cooperative Trials Groups
Funder
National Health and Medical Research Council
Funding Amount
$1,840,000.00
Summary
Each year, 85,000 Australian develop cancer and 35,000 die of it. The Clinical Oncological Society of Australia and nine Australian cancer trials groups run studies that test new and better ways of preventing, curing, treating and palliating people affected by cancer. This grant will help these groups start trials faster; run them more efficiently; coordinate quality assurance; and standardize operating procedures. This grant will enable collaboration that increases the speed, efficiency and qua ....Each year, 85,000 Australian develop cancer and 35,000 die of it. The Clinical Oncological Society of Australia and nine Australian cancer trials groups run studies that test new and better ways of preventing, curing, treating and palliating people affected by cancer. This grant will help these groups start trials faster; run them more efficiently; coordinate quality assurance; and standardize operating procedures. This grant will enable collaboration that increases the speed, efficiency and quality of cancer research to lessen the suffering of people affected by cancer.Read moreRead less
I am a perinatal epidemiologist and public health physician working in pregnancy and child birth research to improve the health and well-being of mothers and babies. My research encompasses the use of population health data to evaluate perinatal health a