Spatial Convergence Of Dementia And Cardiovascular Disease Risk: Evidence To Inform Policy And Practice
Funder
Dementia Australia Research Foundation
Funding Amount
$75,000.00
Summary
This research will use a new method to develop detailed risk-clustering maps identifying where geographical hotspots of dementia and cardiovascular disease (CVD) risk overlap across local neighbourhoods/communities in major urban centres. Building on this information, this research will provide visual tools to show how built environment (i.e. access to open green spaces, air pollution, and socio-economic status) and lifestyle factors (i.e. physical activity, fast food consumption) overlap with r ....This research will use a new method to develop detailed risk-clustering maps identifying where geographical hotspots of dementia and cardiovascular disease (CVD) risk overlap across local neighbourhoods/communities in major urban centres. Building on this information, this research will provide visual tools to show how built environment (i.e. access to open green spaces, air pollution, and socio-economic status) and lifestyle factors (i.e. physical activity, fast food consumption) overlap with risk clusters. These maps will be of direct practical use to researchers and policymakers for targeting effective prevention interventions to communities at higher risk.Read moreRead less
Growth hormone is responsible for normal postnatal growth, is an important metabolic regulator in starvation, and has many useful therapeutic applications, including forms of cardiac insufficiency, Crohns disease and, it is thought, amelioration of ageing. The means whereby GH brings about these changes are not known, although we do know a considerable amount about how the individual domains within the GH receptor signal. What we do not know is which genes are regulated by GH in these processes, ....Growth hormone is responsible for normal postnatal growth, is an important metabolic regulator in starvation, and has many useful therapeutic applications, including forms of cardiac insufficiency, Crohns disease and, it is thought, amelioration of ageing. The means whereby GH brings about these changes are not known, although we do know a considerable amount about how the individual domains within the GH receptor signal. What we do not know is which genes are regulated by GH in these processes, and how this will change the state of the cell. We propose here to use the new technique of gene arrays to uncover the programs, or groups of genes, which GH regulates to change important cellular processes. When used in conjunction with cells expressing GH receptor mutants which are unable to signal to defined pathways, we will be able to know which functional families genes are regulated, and how they are regulated. This information will enable us to know how GH regulates cell growth and metabolism, and therfore to understand what goes wrong when GH or its mediator, IGF-1 , are abnormal. We can also use this information to validate small molecules designed to mimic GH through activating its receptor, to be certain that they are acting in the same way as GH.Read moreRead less